公开(公告)号：US20190070205A1

公开(公告)日：2019-03-07

申请号：US16122087

申请日：2018-09-05

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： EHSAN JABBARZADEH ,  SARA ESLAMBOLCHI MOGHADAM

IPC: A61K31/7048 ,  A61K36/185 ,  A61P17/02

Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of at least one of a flavonoid and a chlorogenic acid that are natural extracts of Parrotia persica, or their derivatives, analogues, or homologs. Compounds based upon these natural extracts have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.

公开(公告)号：US20200368180A1

公开(公告)日：2020-11-26

申请号：US16985476

申请日：2020-08-05

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： EHSAN JABBARZADEH ,  WESLEY F. TAYLOR ,  SARA ESLAMBOLCHI MOGHADAM

IPC: A61K31/122 ,  A61P35/02

Abstract: A deacetylnemorone abietane diterpenoid is utilized in the prevention of growth and development of pathogenic cells, e.g., cancer cells. The deacetylnemorone can have the following structure: or a tautomer there of in which R1, R2, and R3 are independently selected from —H, C1-10 alkyl, C1-10 alkoxy, C1-10 alkenyl, C1-10 alkenoxy, —OH, —OAc, —CHO, -Ph, —OC6H5, —OC6H4OH, —COC6H5, —OCONH2, —OCONHCH3, —OCOC6H4NH2, —NH2, or ═O. The deacetylnemorone shows efficacy in treatment and prevention of a wide range of cancer types, as well as other neoplastic diseases as a chemo-preventative, a primary or secondary cytotoxic agent, a sensitizer for other therapies, or one component of a combinatorial treatment.