公开(公告)号：US20200368180A1

公开(公告)日：2020-11-26

申请号：US16985476

申请日：2020-08-05

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： EHSAN JABBARZADEH ,  WESLEY F. TAYLOR ,  SARA ESLAMBOLCHI MOGHADAM

IPC: A61K31/122 ,  A61P35/02

Abstract: A deacetylnemorone abietane diterpenoid is utilized in the prevention of growth and development of pathogenic cells, e.g., cancer cells. The deacetylnemorone can have the following structure: or a tautomer there of in which R1, R2, and R3 are independently selected from —H, C1-10 alkyl, C1-10 alkoxy, C1-10 alkenyl, C1-10 alkenoxy, —OH, —OAc, —CHO, -Ph, —OC6H5, —OC6H4OH, —COC6H5, —OCONH2, —OCONHCH3, —OCOC6H4NH2, —NH2, or ═O. The deacetylnemorone shows efficacy in treatment and prevention of a wide range of cancer types, as well as other neoplastic diseases as a chemo-preventative, a primary or secondary cytotoxic agent, a sensitizer for other therapies, or one component of a combinatorial treatment.