公开(公告)号：US20240412338A1

公开(公告)日：2024-12-12

申请号：US18694889

申请日：2022-09-22

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Hsiao-Ju CHIANG ,  Eun Sang KOO ,  Scott E. FRASER ,  Francesco CUTRALE

IPC: G06T5/70 ,  G01J3/28 ,  G06T5/10

Abstract: Hybrid unmixing technique (HyU) of this disclosure may provide enhanced imaging of multiplexed fluorescence labels, enabling longitudinal imaging of multiple fluorescent signals with reduced illumination intensities. This disclosure generally relates to imaging systems. This disclosure relates to hyperspectral imaging systems. This disclosure further relates to hyperspectral imaging systems that generate an unmixed color image of a target. This disclosure further relates to a hyperspectral imaging system that is configured to use a hybrid unmixing technique to provide enhanced imaging of a target. This disclosure further relates to a hyperspectral imaging system that is configured to use a hybrid unmixing technique to provide enhanced imaging of multiplexed fluorescence labels, enabling longitudinal imaging of multiple fluorescent signals with reduced illumination intensities. This disclosure further relates to hyperspectral imaging systems that are used in diagnosing a health condition.