公开(公告)号：US20240412338A1

公开(公告)日：2024-12-12

申请号：US18694889

申请日：2022-09-22

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Hsiao-Ju CHIANG ,  Eun Sang KOO ,  Scott E. FRASER ,  Francesco CUTRALE

IPC: G06T5/70 ,  G01J3/28 ,  G06T5/10

Abstract: Hybrid unmixing technique (HyU) of this disclosure may provide enhanced imaging of multiplexed fluorescence labels, enabling longitudinal imaging of multiple fluorescent signals with reduced illumination intensities. This disclosure generally relates to imaging systems. This disclosure relates to hyperspectral imaging systems. This disclosure further relates to hyperspectral imaging systems that generate an unmixed color image of a target. This disclosure further relates to a hyperspectral imaging system that is configured to use a hybrid unmixing technique to provide enhanced imaging of a target. This disclosure further relates to a hyperspectral imaging system that is configured to use a hybrid unmixing technique to provide enhanced imaging of multiplexed fluorescence labels, enabling longitudinal imaging of multiple fluorescent signals with reduced illumination intensities. This disclosure further relates to hyperspectral imaging systems that are used in diagnosing a health condition.

公开(公告)号：US20220108430A1

公开(公告)日：2022-04-07

申请号：US17427890

申请日：2020-01-31

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Wen SHI ,  Eun Sang KOO ,  Scott E. FRASER ,  Francesco CUTRALE

IPC: G06T5/10 ,  G06T5/00 ,  G01J3/28

Abstract: This invention relates to a hyperspectral imaging system for denoising and/or color unmixing multiple overlapping spectra in a low signal-to-noise regime with a fast analysis time. This system may carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze hyper-spectral time-lapse data. For example, this system may carry out Hyper-Spectral Phasors (HySP) calculations to effectively analyze five-dimensional (5D) hyper-spectral time-lapse data. Advantages of this imaging system may include: (a) fast computational speed, (b) the ease of phasor analysis, and (c) a denoising algorithm to obtain the minimally-acceptable signal-to-noise ratio (SNR). An unmixed color image of a target may be generated. These images may be used in diagnosis of a health condition, which may enhance a patient's clinical outcome and evolution of the patient's health.

公开(公告)号：US20190380574A1

公开(公告)日：2019-12-19

申请号：US16465070

申请日：2017-11-27

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Yu CHEN ,  Scott E. FRASER

IPC: A61B3/10 ,  G06T5/00 ,  A61B3/12 ,  A61B3/14 ,  A61B3/15 ,  G01B9/02

Abstract: This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system that generates an image with improved quality. In one example, the OCT system may generate an improved Bscan image by using multiple shaping functions to shape the raw A-scans. In another example, the OCT system may generate the improved B-scan image by forming multiple apodization patterns on a detector and acquiring raw A-scans by using the apodization patterns. A better diagnosis of a health condition may be reached by using the improved images generated by the OCT system of this disclosure.

公开(公告)号：US20150223739A1

公开(公告)日：2015-08-13

申请号：US14621286

申请日：2015-02-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Sameer WALAVALKAR ,  Chieh-feng CHANG ,  Axel SCHERER ,  Brandon MARIN ,  Scott E. FRASER

IPC: A61B5/1459 ,  A61B5/1473 ,  A61B5/07 ,  A61B5/00 ,  H01L27/146 ,  G01N21/65

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/076 ,  A61B5/14735 ,  A61B5/6848 ,  A61B5/686 ,  A61B2562/0233 ,  A61B2562/0285 ,  A61B2562/12 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/658 ,  H01L27/14698

Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

Abstract translation: 描述了纳米柱传感器的方法和系统。 纳米玻璃可以在基底上定义，金属沉积在纳米柱上。 热处理可以回流纳米柱上的金属，在纳米柱的顶端形成金属灯泡。 这些结构可以在用生物制剂进行功能化时具有增强的光学检测，或者可以通过与纳米柱上的金属层相互作用来检测气体，颗粒和液体。