公开(公告)号：US20160271290A1

公开(公告)日：2016-09-22

申请号：US15074909

申请日：2016-03-18

Applicant: University of Southern California

Inventor： Mark S. Humayun ,  Aldo Oregon ,  Yi Zhang

IPC: A61L15/24 ,  A61F9/007 ,  A61L15/64 ,  A61L15/58 ,  A61L15/44

CPC classification number: A61F9/00727 ,  A61L27/18 ,  A61L27/222 ,  A61L27/225 ,  A61L27/227 ,  A61L27/24 ,  A61L2430/16 ,  C08L65/04

Abstract: Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

Abstract translation: 本文公开的若干实施方案涉及用于治疗或修复对眼组织损伤的组合物和方法。 特别地，几个实施例涉及例如通过粘合剂与损伤的视网膜组织相互作用以修复或修补视网膜的眼睛，从眼底组织撕裂或脱离的贴片。 另外的实施例涉及自组装补丁。

公开(公告)号：US11376344B2

公开(公告)日：2022-07-05

申请号：US16693646

申请日：2019-11-25

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： John J. Whalen, III ,  Niki Bayat ,  Yi Zhang ,  Paulo Falabella ,  Mark E. Thompson ,  Mark S. Humayun

IPC: A61L24/06 ,  A61L24/00 ,  A61L15/60 ,  A61F9/007 ,  A61B17/00

Abstract: The present disclosure describes, among other things, a thereto-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.

公开(公告)号：US20130149351A1

公开(公告)日：2013-06-13

申请号：US13708830

申请日：2012-12-07

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Choon Woo Lee ,  Robert H. Grubbs ,  Paresma Patel ,  Mark Humayun ,  Kenrick Kuwahara ,  Victoria A. Piunova ,  Michael Janusz Koss ,  Yi Zhang

IPC: A61K9/00 ,  C12N5/071 ,  C08G63/91

CPC classification number: A61K9/00 ,  C08G63/912 ,  C08J7/18 ,  C08L67/04 ,  C12N5/0068 ,  C12N5/0621 ,  C12N2533/40 ,  C12N2533/50 ,  Y10T428/31725

Abstract: The present invention provides for scaffolds for growing RPE cells, comprising two or more biodegradable polymers. The present invention also provides for methods for creating a scaffold for growing RPE cells. Additionally, the present invention provides for RGD peptide linked polymer scaffolds for supporting the growth of RPE cells. The present invention provides methods of culturing RPE cells using the scaffolds produced herein. The present invention also provides methods of treating vision loss through the administration of RPE cell attached RGD peptide linked polymer scaffolds produced herein. The present invention further provides kits for treating vision loss.

Abstract translation: 本发明提供用于生长RPE细胞的支架，其包含两种或更多种可生物降解的聚合物。 本发明还提供了用于产生用于培养RPE细胞的支架的方法。 另外，本发明提供了用于支持RPE细胞生长的RGD肽连接的聚合物支架。 本发明提供使用本文生产的支架培养RPE细胞的方法。 本发明还提供了通过施用本文生产的RPE细胞附着的RGD肽连接的聚合物支架来治疗视力丧失的方法。 本发明还提供了用于治疗视力丧失的试剂盒。

公开(公告)号：US10849788B2

公开(公告)日：2020-12-01

申请号：US15074909

申请日：2016-03-18

Applicant: University of Southern California

Inventor： Mark S. Humayun ,  Aldo Oregon ,  Yi Zhang

IPC: A61F9/007 ,  A61L27/22 ,  A61L27/24 ,  A61L27/18

Abstract: Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

公开(公告)号：US11793672B2

公开(公告)日：2023-10-24

申请号：US17102078

申请日：2020-11-23

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Mark S. Humayun ,  Aldo Oregon ,  Yi Zhang

IPC: A61F9/007 ,  A61L27/22 ,  A61L27/24 ,  A61L27/18

CPC classification number: A61F9/00727 ,  A61L27/18 ,  A61L27/222 ,  A61L27/225 ,  A61L27/227 ,  A61L27/24 ,  A61L2430/16 ,  A61L27/18 ,  C08L65/04

Abstract: Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

公开(公告)号：US10512707B2

公开(公告)日：2019-12-24

申请号：US15013632

申请日：2016-02-02

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： John J. Whalen, III ,  Niki Bayat ,  Yi Zhang ,  Paulo Falabella ,  Mark E. Thompson ,  Mark S. Humayun

IPC: A61L24/06 ,  A61L24/00 ,  A61L15/60 ,  A61F9/007 ,  A61B17/00

Abstract: The present disclosure describes, among other things, a thermo-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.