-
公开(公告)号：US20210267573A1
公开(公告)日：2021-09-02
申请号：US17315039
申请日：2021-05-07
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Christopher F. Reiche , Florian Solzbacher , Navid Farhoudi , Steven M. Blair , Jules J. Magda , Lars B. Laurentius , Prattay Deepta Kairy
Abstract: Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.
-
2.发明公开公开(公告)号：US20230243773A1
公开(公告)日：2023-08-03
申请号：US18161697
申请日：2023-01-30
Applicant: University of Utah Research Foundation
Inventor： Christopher F. Reiche , Julia Koerner , Benozir Ahmed , Florian Solzbacher , Jules J. Magda
CPC classification number: G01N27/227 , G01N27/126 , A61B5/14546 , A61B5/14539 , A61B2562/12
Abstract: A power transfer-based flexible sensing platform that can be used in a fluid environment includes at least one metallic thin film structure, with a polymeric encapsulation that protects the metallic thin film structure from the fluid environment, a smart hydrogel sandwiched between layers of the metallic thin film structure, the smart hydrogel being configured to swell or shrink in response to stimulus, and an AC power source or signal generator electrically connected to the at least one metallic film structure. The metallic thin film can include first and second U-shaped metallic thin film structures, each encapsulated, where the smart hydrogel is sandwiched between them. An AC power or signal source is electrically connected to one of the U-shaped structures, causing power to be inductively transferred to the other. Measurement of the induced power or other signal can be used to determine a concentration of an analyte in the fluid environment.
-
公开(公告)号：US11980498B2
公开(公告)日：2024-05-14
申请号：US17315039
申请日：2021-05-07
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Christopher F. Reiche , Florian Solzbacher , Navid Farhoudi , Steven M. Blair , Jules J. Magda , Lars B. Laurentius , Prattay Deepta Kairy
CPC classification number: A61B8/4272 , A61B8/4483 , A61B8/5207 , G10K11/04 , A61B2562/0204 , A61B2562/028
Abstract: Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.
-
Patent Agency Ranking
公开(公告)号：US20190192113A1
公开(公告)日：2019-06-27
申请号：US16330048
申请日：2017-09-01
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION , Sentiomed, Inc.
Inventor： Mahender nath Avula , Douglas A. Christensen , Navid Farhoudi , Stan Kanarowski , Julia Koerner , Jules John Magda , Rami Sami Marrouche , Christopher F. Reiche , Florian Solzbacher , Michael David Sorenson
CPC classification number: A61B8/0841 , A61B8/12 , A61B8/481 , A61B90/39 , A61B2090/3929
Abstract: Systems and methods for accurately measuring changes in biomarker sensitive hydrogel volume and shape due to exposure to various biomarkers include a system for identifying one or more dimensional changes in a biomarker sensitive hydrogel positioned within an in vivo environment. The system includes a biomarker sensitive hydrogel positioned within an in vivo environment and configured to dimensionally change in response to interaction with predefined biomarkers. The system additionally includes an ultrasound transducer for locating and identifying one or more characteristics of the biomarker sensitive hydrogel and a computer system in electrical communication with the ultrasound transducer. The computer system is configured to receive characteristics of the biomarker sensitive hydrogel from the ultrasound transducer and determine dimensional changes of the biomarker sensitive hydrogel based on the received characteristics.
-
公开(公告)号：US20230147961A1
公开(公告)日：2023-05-11
申请号：US17920695
申请日：2022-04-15
Applicant: University of Utah Research Foundation
Inventor： Yantao Fan , Christopher F. Reiche , Florian Solzbacher
CPC classification number: A61B5/0004 , A61B5/262
Abstract: A transition microelectrode (108) can include a micro well array (104) having a plurality of microwells. The transition microelectrode (108) can further include a plurality of neuronal soma oriented within the plurality of microwells. A bioerodible probe guide (106) can be oriented over the microwell array (104). An electrode (103) can be electrically connected with the plurality of microwells. A transition microelectrode array (116) can include an electrode array having a plurality of the transition microelectrodes (108).
-
6.发明申请公开(公告)号：US20210338195A1
公开(公告)日：2021-11-04
申请号：US17366743
申请日：2021-07-02
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Christopher F. Reiche , Navid Farhoudi , Florian Solzbacher , Jules J. Magda
Abstract: Microresonator structures including a top polymer film layer, a bottom polymer film layer, and a smart hydrogel structure sandwiched between the polymer film layers. An ultrasound resonator cavity having a resonance frequency is defined between the top and bottom polymer layers, and the smart hydrogel structure is configured to provide a change in height to the ultrasound resonator cavity due to volumetric expansion or contraction of the smart hydrogel structure, in response to interaction of the smart hydrogel structure with one or more predefined analytes in an in vivo or other environment. Related methods of use for determining the presence or concentration of a given target analyte, as well as methods of fabricating such microresonator structures are also described.
-
7.发明公开公开(公告)号：US20240260935A1
公开(公告)日：2024-08-08
申请号：US18621918
申请日：2024-03-29
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Christopher F. Reiche , Florian Solzbacher , Navid Farhoudi , Steven M. Blair , Jules J. Magda , Lars B. Laurentius , Prattay Deepta Kairy
CPC classification number: A61B8/4272 , A61B8/4483 , A61B8/5207 , G10K11/04 , A61B2562/0204 , A61B2562/028
Abstract: Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.
-
公开(公告)号：US11445997B2
公开(公告)日：2022-09-20
申请号：US16330048
申请日：2017-09-01
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION , Sentiomed, Inc.
Inventor： Mahender nath Avula , Douglas A. Christensen , Navid Farhoudi , Stan Kanarowski , Julia Koerner , Jules John Magda , Rami Sami Marrouche , Christopher F. Reiche , Florian Solzbacher , Michael David Sorenson
Abstract: Systems and methods for accurately measuring changes in biomarker sensitive hydrogel volume and shape due to exposure to various biomarkers include a system for identifying one or more dimensional changes in a biomarker sensitive hydrogel positioned within an in vivo environment. The system includes a biomarker sensitive hydrogel positioned within an in vivo environment and configured to dimensionally change in response to interaction with predefined biomarkers. The system additionally includes an ultrasound transducer for locating and identifying one or more characteristics of the biomarker sensitive hydrogel and a computer system in electrical communication with the ultrasound transducer. The computer system is configured to receive characteristics of the biomarker sensitive hydrogel from the ultrasound transducer and determine dimensional changes of the biomarker sensitive hydrogel based on the received characteristics.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.015 seconds)
