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公开(公告)号：US20210267573A1
公开(公告)日：2021-09-02
申请号：US17315039
申请日：2021-05-07
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Christopher F. Reiche , Florian Solzbacher , Navid Farhoudi , Steven M. Blair , Jules J. Magda , Lars B. Laurentius , Prattay Deepta Kairy
Abstract: Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.
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公开(公告)号：US11980498B2
公开(公告)日：2024-05-14
申请号：US17315039
申请日：2021-05-07
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Christopher F. Reiche , Florian Solzbacher , Navid Farhoudi , Steven M. Blair , Jules J. Magda , Lars B. Laurentius , Prattay Deepta Kairy
CPC classification number: A61B8/4272 , A61B8/4483 , A61B8/5207 , G10K11/04 , A61B2562/0204 , A61B2562/028
Abstract: Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.
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3.发明公开公开(公告)号：US20240260935A1
公开(公告)日：2024-08-08
申请号：US18621918
申请日：2024-03-29
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Christopher F. Reiche , Florian Solzbacher , Navid Farhoudi , Steven M. Blair , Jules J. Magda , Lars B. Laurentius , Prattay Deepta Kairy
CPC classification number: A61B8/4272 , A61B8/4483 , A61B8/5207 , G10K11/04 , A61B2562/0204 , A61B2562/028
Abstract: Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.
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