公开(公告)号：US20220151950A1

公开(公告)日：2022-05-19

申请号：US17099224

申请日：2020-11-16

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Robert Z. Tashjian ,  Peter N. Chalmers ,  T. Wade Fallin ,  James M. Hotaling

IPC: A61K31/05 ,  A61P21/00 ,  A61P19/00 ,  A61K45/06 ,  A61L17/00 ,  A61K9/70

Abstract: Disclosed are devices and methods for improving healing of an enthesis. An effective amount of a composition comprising one or more sex steroids and/or sex steroid equivalents is locally administered at the site of a repaired enthesis. The composition causes upregulation of one or more chondrogenic, angiogenic, and/or tendon modulation genes, resulting in improved healing of the enthesis. The improved enthesis healing occurs even where the subject has normal levels of sex hormones.

公开(公告)号：US10709373B2

公开(公告)日：2020-07-14

申请号：US15300951

申请日：2015-03-30

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： James M. Hotaling ,  Randy C. Bowen ,  Alvin Y. Le ,  Matthew I. Converse ,  Andrew W. Southwick ,  Tab S. Robbins ,  Kent Ogden ,  Scott McClellan ,  Brian Holt

IPC: A61B5/20 ,  B01L3/00 ,  G01F1/56 ,  G01N27/22 ,  G01N33/493 ,  A61B10/00 ,  A61B5/145 ,  A61B5/00

Abstract: A fluid analysis device including a fluid receipt chamber, a first capacitive element for measuring fluid flow into the fluid receipt chamber and a controller operatively coupled to the first capacitive element, wherein the controller is configured to measure a first capacitance of the first capacitive element.

公开(公告)号：US20240390292A1

公开(公告)日：2024-11-28

申请号：US18793674

申请日：2024-08-02

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Robert Z. Tashjian ,  Peter N. Chalmers ,  T. Wade Fallin ,  James M. Hotaling

IPC: A61K31/05 ,  A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61K9/70 ,  A61K45/06 ,  A61L17/00 ,  A61P19/00 ,  A61P21/00

Abstract: Disclosed are devices and methods for improving healing of an enthesis. An effective amount of a composition comprising one or more sex steroids and/or sex steroid equivalents is locally administered at the site of a repaired enthesis. The composition causes upregulation of one or more chondrogenic, angiogenic, and/or tendon modulation genes, resulting in improved healing of the enthesis. The improved enthesis healing occurs even where the subject has normal levels of sex hormones.

公开(公告)号：US20170020433A1

公开(公告)日：2017-01-26

申请号：US15300951

申请日：2015-03-30

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： James M. Hotaling ,  Randy C. Bowen ,  Alvin Y. Le ,  Matthew I. Converse ,  Andrew W. Southwick ,  Tab S. Robbins ,  Kent Ogden ,  Scott McClellan ,  Brian Holt

IPC: A61B5/20 ,  A61B5/00 ,  G01N33/493 ,  G01N27/22 ,  B01L3/00 ,  A61B5/145 ,  G01F1/56

CPC classification number: A61B5/208 ,  A61B5/0002 ,  A61B5/14507 ,  A61B10/007 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2560/0431 ,  A61B2562/0214 ,  B01L3/502 ,  B01L2200/0605 ,  B01L2200/143 ,  B01L2200/148 ,  B01L2300/0627 ,  B01L2300/0832 ,  B01L2300/0848 ,  G01F1/56 ,  G01N27/221 ,  G01N33/493

Abstract: A fluid analysis device including a fluid receipt chamber, a first capacitive element for measuring fluid flow into the fluid receipt chamber and a controller operatively coupled to the first capacitive element, wherein the controller is configured to measure a first capacitance of the first capacitive element.

Abstract translation: 一种流体分析装置，包括流体接收室，用于测量进入流体接收室的流体流的第一电容元件和可操作地耦合到第一电容元件的控制器，其中控制器被配置为测量第一电容元件的第一电容。