公开(公告)号：US20220151950A1

公开(公告)日：2022-05-19

申请号：US17099224

申请日：2020-11-16

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Robert Z. Tashjian ,  Peter N. Chalmers ,  T. Wade Fallin ,  James M. Hotaling

IPC: A61K31/05 ,  A61P21/00 ,  A61P19/00 ,  A61K45/06 ,  A61L17/00 ,  A61K9/70

Abstract: Disclosed are devices and methods for improving healing of an enthesis. An effective amount of a composition comprising one or more sex steroids and/or sex steroid equivalents is locally administered at the site of a repaired enthesis. The composition causes upregulation of one or more chondrogenic, angiogenic, and/or tendon modulation genes, resulting in improved healing of the enthesis. The improved enthesis healing occurs even where the subject has normal levels of sex hormones.

公开(公告)号：US20240390292A1

公开(公告)日：2024-11-28

申请号：US18793674

申请日：2024-08-02

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Robert Z. Tashjian ,  Peter N. Chalmers ,  T. Wade Fallin ,  James M. Hotaling

IPC: A61K31/05 ,  A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61K9/70 ,  A61K45/06 ,  A61L17/00 ,  A61P19/00 ,  A61P21/00

Abstract: Disclosed are devices and methods for improving healing of an enthesis. An effective amount of a composition comprising one or more sex steroids and/or sex steroid equivalents is locally administered at the site of a repaired enthesis. The composition causes upregulation of one or more chondrogenic, angiogenic, and/or tendon modulation genes, resulting in improved healing of the enthesis. The improved enthesis healing occurs even where the subject has normal levels of sex hormones.