公开(公告)号：US20240285530A1

公开(公告)日：2024-08-29

申请号：US18112720

申请日：2023-02-22

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Nitish KHURANA ,  Hamidreza GHANDEHARI ,  Kevin WATT ,  Venkata YELLEPEDDI

IPC: A61K9/107 ,  A61K9/127 ,  A61K31/05

CPC classification number: A61K9/1075 ,  A61K9/1271 ,  A61K31/05 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: Described herein are methods for administering a hydrophobic pharmaceutical agent to subjects undergoing extracorporeal membrane oxygenation (ECMO) device therapy while diminishing adsorption of the hydrophobic pharmaceutical agent to the ECMO device. In one embodiment, the method comprises administering the hydrophobic pharmaceutical agent encapsulated in an amphipathic encapsulating agent. In one aspect, the hydrophobic pharmaceutical agent is propofol and the amphipathic encapsulating agent is polyethylene-polypropylene glycol (Poloxamer 407) or a PEGylated liposome. In another aspect, PEGylated propofol is synthesized and used to prevent adsorption to the ECMO device.