公开(公告)号：US20240285530A1

公开(公告)日：2024-08-29

申请号：US18112720

申请日：2023-02-22

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Nitish KHURANA ,  Hamidreza GHANDEHARI ,  Kevin WATT ,  Venkata YELLEPEDDI

IPC: A61K9/107 ,  A61K9/127 ,  A61K31/05

CPC classification number: A61K9/1075 ,  A61K9/1271 ,  A61K31/05 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: Described herein are methods for administering a hydrophobic pharmaceutical agent to subjects undergoing extracorporeal membrane oxygenation (ECMO) device therapy while diminishing adsorption of the hydrophobic pharmaceutical agent to the ECMO device. In one embodiment, the method comprises administering the hydrophobic pharmaceutical agent encapsulated in an amphipathic encapsulating agent. In one aspect, the hydrophobic pharmaceutical agent is propofol and the amphipathic encapsulating agent is polyethylene-polypropylene glycol (Poloxamer 407) or a PEGylated liposome. In another aspect, PEGylated propofol is synthesized and used to prevent adsorption to the ECMO device.

公开(公告)号：US20190209606A1

公开(公告)日：2019-07-11

申请号：US16333434

申请日：2017-09-14

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Hamidreza GHANDEHARI ,  Siam OOTTAMASATHIEN ,  Mark Martin JENSEN ,  Joseph CAPPELLO ,  Wanjian JIA ,  Glenn D. PRESTWICH

IPC: A61K31/737 ,  A61K9/00 ,  A61K9/06 ,  A61K31/728 ,  A61K47/42 ,  A61K45/06 ,  A61P29/00

CPC classification number: A61K31/737 ,  A61K9/0019 ,  A61K9/06 ,  A61K31/728 ,  A61K45/06 ,  A61K47/36 ,  A61K47/42 ,  A61P29/00 ,  C07K14/78

Abstract: Described herein are in situ gelling compositions. The compositions include an anti-inflammatory polysaccharide and a gelling polymer, wherein the composition is a liquid prior to administration to a subject but converts to a gel upon administration to the subject. The compositions described herein have numerous applications with respect to the local treatment (reduction or prevention) of inflammation and/or tissue damage.