公开(公告)号：US20230277483A1

公开(公告)日：2023-09-07

申请号：US18110094

申请日：2023-02-15

Applicant: University of Iowa Research Foundation

Inventor： Liu Hong ,  Jeff Banas ,  Ling Yang ,  Min Zhu ,  Yi Shu

IPC: A61K31/19 ,  A61K47/54 ,  A61K47/64 ,  A61P1/02 ,  A61P29/00 ,  A61P3/04

CPC classification number: A61K31/19 ,  A61K47/54 ,  A61K47/64 ,  A61P1/02 ,  A61P29/00 ,  A61P3/04

Abstract: A composition comprising an amount of one or more agents comprising a hydroxy(C1-10)(COOH) or salt thereof, wherein C1-10 can be substituted or form a ring, a dicarboxylic acid, a purine nucleoside or analog thereof, a pyrimidine nucleoside or an analog thereof, or an amino acid or analog thereof, effective to inhibit inflammation, and methods of using the composition, are provided.

公开(公告)号：US20200147060A1

公开(公告)日：2020-05-14

申请号：US16668736

申请日：2019-10-30

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Somya Kapoor ,  Douglas R. Spitz ,  Andrean Burnett ,  Ling Yang

IPC: A61K31/437 ,  A61K31/197 ,  A61K31/192 ,  A61K31/472 ,  A61P35/00

Abstract: The invention provides in certain embodiments a therapeutic regimen comprising (a) an anti-cancer combination of vemurafenib and cobimetinib, or a combination of trametinib and dabrafenib, and (b) a secondary agent comprising L-buthionine-[S,R]-sulfoximine (BSO), or phenyl butyric acid (PBA) or a pharmaceutically acceptable salt thereof, and chloroquine or hydrochloroquine (HCQ) for the therapeutic treatment of a hyperproliferative disorder.