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公开(公告)号：US20210177986A1
公开(公告)日：2021-06-17
申请号：US17151898
申请日：2021-01-19
Applicant: University of Utah Research Foundation
Inventor： Youngwook Won , David A. Bull , Kwangsuk Lim
IPC: A61K47/68 , C07K16/32 , A61K9/00 , A61K31/27 , A61K31/337
Abstract: Disclosed herein, is a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains, and one or more therapeutic agents, wherein the therapeutic agent is allosterically bound to the biological binding domain. Also described herein, are methods of incorporating a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains that captures the therapeutic agent without the formation of a chemical bond, and one or more therapeutic agents physiologically acceptable compositions including them; and methods of administering the bi-functional allosteric protein-drug molecule to patients for the treatment of cancer.
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公开(公告)号：US20170368196A1
公开(公告)日：2017-12-28
申请号：US15534948
申请日：2015-12-11
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Youngwook Won , David A. Bull , Kwangsuk Lim
IPC: A61K47/68 , A61K31/27 , A61K9/00 , A61K31/337
CPC classification number: A61K47/6855 , A61K9/0019 , A61K31/27 , A61K31/337 , A61K47/6801 , A61K47/6803 , A61K47/6849 , A61K47/6879 , A61K47/6889 , C07K16/32 , C07K2317/622 , C07K2319/33
Abstract: Disclosed herein, is a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains, and one or more therapeutic agents, wherein the therapeutic agent is allosterically bound to the biological binding domain. Also described herein, are methods of incorporating a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains that captures the therapeutic agent without the formation of a chemical bond, and one or more therapeutic agents; physiologically acceptable compositions including them; and methods of administering the bi-functional allosteric protein-drug molecule to patients for the treatment of cancer.
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Patent Agency Ranking
3.发明申请公开(公告)号：US20150057339A1
公开(公告)日：2015-02-26
申请号：US14373312
申请日：2013-01-18
Applicant: University of Utah Research Foundation
Inventor： Sung Wan Kim , Hye Yeong Nam , Kihoon Nam , David A. Bull
CPC classification number: A61K48/0041 , A61K47/34 , A61K47/595 , C12N15/111 , C12N15/85 , C12N2310/14 , C12N2320/32
Abstract: The polymeric carrier for delivering nucleic acid material to a cell is provided herein. The polymeric carrier can include a dendrimer group having 2 to 8 termini, each of the termini having an arginine-grafted bioreducible polymer attached thereto. In one embodiment, only a portion of the termini can have an arginine-grafted bioreducible polymer attached thereto.
Abstract translation: 本文提供了用于将核酸材料递送至细胞的聚合物载体。 聚合物载体可以包括具有2至8个末端的树枝状聚合物基团，每个末端具有连接到其上的精氨酸接枝的生物还原性聚合物。 在一个实施方案中，仅一部分末端可以具有连接到其上的精氨酸接枝的生物还原性聚合物。
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公开(公告)号：US09907861B2
公开(公告)日：2018-03-06
申请号：US14373312
申请日：2013-01-18
Applicant: University of Utah Research Foundation
Inventor： Sung Wan Kim , Hye Yeong Nam , Kihoon Nam , David A. Bull
CPC classification number: A61K48/0041 , A61K47/34 , A61K47/595 , C12N15/111 , C12N15/85 , C12N2310/14 , C12N2320/32
Abstract: The polymeric carrier for delivering nucleic acid material to a cell is provided herein. The polymeric carrier can include a dendrimer group having 2 to 8 termini, each of the termini having an arginine-grafted bioreducible polymer attached thereto. In one embodiment, only a portion of the termini can have an arginine-grafted bioreducible polymer attached thereto.
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公开(公告)号：US12180300B2
公开(公告)日：2024-12-31
申请号：US17277828
申请日：2019-09-20
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Youngwook Won , David A. Bull , Daniel Yongwon Lee
Abstract: Surface-engineered immune cells, such as natural killer cells, grafted with targeting moiety-drug complexes. The present invention combines chemotherapy and immunotherapy by engineering the immune cells to target specific tumor cells through antigen recognition and deliver potent chemotherapeutic agents, thereby destroying the tumor cells. The surface-engineered immune cells may be prepared using a one-step method. The present invention also provides kits for preparing the surface-engineered immune cells.
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公开(公告)号：US10898582B2
公开(公告)日：2021-01-26
申请号：US15534948
申请日：2015-12-11
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Youngwook Won , David A. Bull , Kwangsuk Lim
IPC: A61K47/68 , C07K16/32 , A61K9/00 , A61K31/27 , A61K31/337
Abstract: Disclosed herein, is a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains, and one or more therapeutic agents, wherein the therapeutic agent is allosterically bound to the biological binding domain. Also described herein, are methods of incorporating a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains that captures the therapeutic agent without the formation of a chemical bond, and one or more therapeutic agents; physiologically acceptable compositions including them; and methods of administering the bi-functional allosteric protein-drug molecule to patients for the treatment of cancer.
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公开(公告)号：US10279047B2
公开(公告)日：2019-05-07
申请号：US15113009
申请日：2015-01-20
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Young-Wook Won , David A. Bull , Amit N. Patel
IPC: A61K47/00 , A61K38/00 , A61K47/44 , A61K47/50 , A61K47/48 , C12N5/00 , C12N5/0775 , A61K49/00 , A61K35/28 , A61K47/64 , A61K47/69 , A61K35/12
Abstract: Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety. Also described herein are methods for treating disease states, such as acute myocardial ischemia or infarction, with said compositions, in a subject.
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