公开(公告)号：US20210177986A1

公开(公告)日：2021-06-17

申请号：US17151898

申请日：2021-01-19

Applicant: University of Utah Research Foundation

Inventor： Youngwook Won ,  David A. Bull ,  Kwangsuk Lim

IPC: A61K47/68 ,  C07K16/32 ,  A61K9/00 ,  A61K31/27 ,  A61K31/337

Abstract: Disclosed herein, is a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains, and one or more therapeutic agents, wherein the therapeutic agent is allosterically bound to the biological binding domain. Also described herein, are methods of incorporating a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains that captures the therapeutic agent without the formation of a chemical bond, and one or more therapeutic agents physiologically acceptable compositions including them; and methods of administering the bi-functional allosteric protein-drug molecule to patients for the treatment of cancer.

公开(公告)号：US10898582B2

公开(公告)日：2021-01-26

申请号：US15534948

申请日：2015-12-11

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Youngwook Won ,  David A. Bull ,  Kwangsuk Lim

IPC: A61K47/68 ,  C07K16/32 ,  A61K9/00 ,  A61K31/27 ,  A61K31/337

Abstract: Disclosed herein, is a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains, and one or more therapeutic agents, wherein the therapeutic agent is allosterically bound to the biological binding domain. Also described herein, are methods of incorporating a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains that captures the therapeutic agent without the formation of a chemical bond, and one or more therapeutic agents; physiologically acceptable compositions including them; and methods of administering the bi-functional allosteric protein-drug molecule to patients for the treatment of cancer.

公开(公告)号：US20170368196A1

公开(公告)日：2017-12-28

申请号：US15534948

申请日：2015-12-11

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Youngwook Won ,  David A. Bull ,  Kwangsuk Lim

IPC: A61K47/68 ,  A61K31/27 ,  A61K9/00 ,  A61K31/337

CPC classification number: A61K47/6855 ,  A61K9/0019 ,  A61K31/27 ,  A61K31/337 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6879 ,  A61K47/6889 ,  C07K16/32 ,  C07K2317/622 ,  C07K2319/33

Abstract: Disclosed herein, is a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains, and one or more therapeutic agents, wherein the therapeutic agent is allosterically bound to the biological binding domain. Also described herein, are methods of incorporating a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains that captures the therapeutic agent without the formation of a chemical bond, and one or more therapeutic agents; physiologically acceptable compositions including them; and methods of administering the bi-functional allosteric protein-drug molecule to patients for the treatment of cancer.