公开(公告)号：US20210386790A1

公开(公告)日：2021-12-16

申请号：US17422646

申请日：2020-01-15

Applicant: University of Utah Research Foundation

Inventor： Goro Kuramoto ,  Teruo Okano ,  Robert Silver ,  David Grainger

IPC: A61K35/28 ,  A61K35/51 ,  A61L27/38

Abstract: The disclosure provides a method of reducing formation of fibrotic tissue in a uterus of a subject in need thereof, comprising applying a mesenchymal stem cell (MSC) sheet to the uterus of the subject, wherein the MSC sheet comprises one or more layers of aggregated confluent mesenchymal stem cells (MSCs), and wherein applying the MSC sheet to the uterus reduces the formation of fibrotic tissue in the uterus relative to a uterus in which the MSC sheet is not applied. The disclosure also provides a method of increasing myometrial regeneration in a uterus of a subject in need thereof, comprising applying a mesenchymal stem cell (MSC) sheet to the uterus of the subject, wherein the MSC sheet comprises one or more layers of aggregated confluent mesenchymal stem cells (MSCs), and wherein applying the MSC sheet to the uterus increases myometrial regeneration relative to a uterus in which the MSC sheet is not applied.