公开(公告)号：US20250084089A1

公开(公告)日：2025-03-13

申请号：US18821262

申请日：2024-08-30

Applicant: University of Windsor

Inventor： John F. Trant ,  Lisa A. Porter ,  Bre-Anne Fifield ,  Daniel Meister ,  John J. Hayward ,  Lavleen Mader ,  Maria Teodora Secara

IPC: C07D487/04 ,  A61K31/519 ,  G01N33/574

Abstract: In a preferred embodiment, there is provided a compound having structural Formula I, II, III or IV.

公开(公告)号：US20240400533A1

公开(公告)日：2024-12-05

申请号：US18678589

申请日：2024-05-30

Applicant: University of Windsor

Inventor： John F. TRANT ,  Sarah Nasri ,  John J. Hayward

IPC: C07D323/00

Abstract: In a preferred embodiment, there is provided a method for preparing a crown ether, the method comprising: loading a resin having a resin functional group with a linking compound having a functional group selected for coupling to the resin functional group and at least two carbon atoms each having a substituent; coupling the linking compound to a polyethylene glycol having two terminal carbon atoms each bonded to an optionally protected terminal hydroxyl group to obtain a cyclized intermediate, whereby one said at least two carbon atoms or the substituent and an associated one of the two terminal carbon atoms or the hydroxyl groups undergo a coupling or substitution reaction; and removing the linking compound and the cyclized intermediate from the resin.