公开(公告)号：US11746114B2

公开(公告)日：2023-09-05

申请号：US17665253

申请日：2022-02-04

Applicant: University of Windsor

Inventor： John Frederick Trant ,  Sarah Nasri ,  Maryamalsadat Kosar ,  Sanaz Nadimi ,  Mohaddeseh Dashti Nejad Pour ,  Purshotam Sharma ,  Seyedeh Maryamdokht Taimoory

IPC: C07D491/18 ,  C07K1/06

CPC classification number: C07D491/18 ,  C07K1/067

Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.

公开(公告)号：US20220153749A1

公开(公告)日：2022-05-19

申请号：US17665253

申请日：2022-02-04

Applicant: University of Windsor

Inventor： John Frederick TRANT ,  Sarah Nasri ,  Maryamalsadat Kosar ,  Sanaz Nadimi ,  Mohaddeseh Dashti Nejad Pour ,  Purshotam Sharma ,  Seyedeh Maryamdokht Taimoory

IPC: C07D491/18 ,  C07K1/06

Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.

公开(公告)号：US20240400533A1

公开(公告)日：2024-12-05

申请号：US18678589

申请日：2024-05-30

Applicant: University of Windsor

Inventor： John F. TRANT ,  Sarah Nasri ,  John J. Hayward

IPC: C07D323/00

Abstract: In a preferred embodiment, there is provided a method for preparing a crown ether, the method comprising: loading a resin having a resin functional group with a linking compound having a functional group selected for coupling to the resin functional group and at least two carbon atoms each having a substituent; coupling the linking compound to a polyethylene glycol having two terminal carbon atoms each bonded to an optionally protected terminal hydroxyl group to obtain a cyclized intermediate, whereby one said at least two carbon atoms or the substituent and an associated one of the two terminal carbon atoms or the hydroxyl groups undergo a coupling or substitution reaction; and removing the linking compound and the cyclized intermediate from the resin.

公开(公告)号：US11560387B2

公开(公告)日：2023-01-24

申请号：US17468048

申请日：2021-09-07

Applicant: University of Windsor

Inventor： John Frederick Trant ,  Daniel Meister ,  Sarah Nasri ,  Anthony Emanuel Chifor ,  John James Hayward ,  Seyedeh Maryamdokht Taimoory ,  Mohadeseh Dashti-Pour

IPC: C07D491/18 ,  C07K1/06

Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.