公开(公告)号：US20230280338A1

公开(公告)日：2023-09-07

申请号：US18015463

申请日：2021-07-09

Applicant: VIDYA HOLDINGS LTD

Inventor： Marko Dorrestijn ,  David R. Klug ,  Vladimir Turek ,  Stefan Leo Van Workum

IPC: G01N33/543 ,  G01N21/63

CPC classification number: G01N33/54373 ,  G01N21/63 ,  G01N2201/121

Abstract: An apparatus for creating and correcting a two dimensional intensity map of one or more assay spots in a detection zone is provided. The apparatus comprising, a locator for affirming the location of the detection zone; a total internal reflection excitation device comprising a light source for illuminating the one or more assay spots in the detection zone; a detector configured to receive light that is emitted, reflected or scattered from the one or more assay spots and to create a two dimensional intensity map of the one or more assay spots comprising a two dimensional array of quantitative pixel values; and a processor configured to correct the intensity map to remove noise through analysis of corresponding pixel values from an earlier intensity map; wherein the analysis includes curve fitting.

公开(公告)号：US20230346357A1

公开(公告)日：2023-11-02

申请号：US18021981

申请日：2021-08-20

Applicant: VIDYA HOLDINGS LTD

Inventor： Marko Dorrestijn ,  David R. Klug ,  Vladimir Turek ,  Stefan Leo Van Workum

IPC: A61B10/00 ,  G01N1/40

CPC classification number: A61B10/0051 ,  G01N1/4077 ,  G01N2001/4088

Abstract: A combined sample collection and filtration device is provided for collecting and filtering a fluid sample. The device comprises: a sample collection location; a filter module for removing particulate matter from the fluid sample; the filter module having bubble point and a burst pressure; and one or more voids in communication with the sample collection location for accommodating sample during pressurisation such that the pressure within the device remains below the bubble point and the burst pressure of the filter module.

公开(公告)号：US20230321648A1

公开(公告)日：2023-10-12

申请号：US18022323

申请日：2021-08-20

Applicant: VIDYA HOLDINGS LTD

Inventor： Marko Dorrestijn ,  David Rupert Klug ,  Vladimir Turek ,  Stefan Leo Van Workum

IPC: B01L3/00

CPC classification number: B01L3/5023 ,  B01L3/502746 ,  B01L2400/086 ,  B01L2200/16 ,  B01L2300/069 ,  B01L2300/0681 ,  B01L2300/0816

Abstract: A lateral to free flow assay device is provided for analysis of a fluid sample. The device comprises: a sample collection unit configured to introduce the sample into the device; an optical element configured to facilitate TIR for the analysis of the sample; a fluid pathway configured to provide fluid communication between the sample collection unit and a free flow region adjacent the optical element; a wicking pad defining a lateral flow section of the fluid pathway or provided in the sample collection unit to collect the sample; wherein at least one surface of the optical element defines at least part of the free flow region of the fluid pathway; and wherein the fluid pathway is configured to enable fluid flow from the lateral flow region to the free flow region of the fluid pathway to facilitate the analysis of the sample.