Invention Grant
- Patent Title: Silicone hydrogel lens with a crosslinked hydrophilic coating
- Patent Title (中): 硅胶水凝胶透镜与交联的亲水涂层
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Application No.: US13948206Application Date: 2013-07-23
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Publication No.: US08944592B2Publication Date: 2015-02-03
- Inventor: Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Jian Zhou
- Main IPC: G02C7/00
- IPC: G02C7/00 ; G02C7/02 ; G02B1/04 ; G02C7/04

Abstract:
The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
Public/Granted literature
- US20130308093A1 SILICONE HYDROGEL LENS WITH A CROSSLINKED HYDROPHILIC COATING Public/Granted day:2013-11-21
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