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公开(公告)号：US20190257980A1
公开(公告)日：2019-08-22
申请号：US16398607
申请日：2019-04-30
Applicant: Novartis AG
Inventor： Xinming Qian , Frank Chang , Yasuo Matsuzawa , Venkat Shankar
Abstract: The invention is related to a medical device comprising a core material made of a crosslinkined silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.
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公开(公告)号：US10324233B2
公开(公告)日：2019-06-18
申请号：US15249577
申请日：2016-08-29
Applicant: Novartis AG
Inventor： Xinming Qian , Frank Chang , Yasuo Matsuzawa , Venkat Shankar
Abstract: The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.
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公开(公告)号：US10253112B2
公开(公告)日：2019-04-09
申请号：US15434101
申请日：2017-02-16
Applicant: Novartis AG
Inventor： Frank Chang , Troy Vernon Holland , Xinming Qian , Robert Scott , Joseph Michael Lindacher , Uwe Haken
Abstract: The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens.
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公开(公告)号：US09950483B2
公开(公告)日：2018-04-24
申请号：US14289046
申请日：2014-05-28
Applicant: Novartis AG
Inventor： Xinming Qian , Frank Chang , Troy Vernon Holland , Yongxing Qiu , Venkat Shankar
CPC classification number: B29D11/00865 , B29D11/00951 , G02B1/043 , C08L83/04 , C08L101/14 , C08L33/26
Abstract: The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.
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公开(公告)号：US20170240658A1
公开(公告)日：2017-08-24
申请号：US15434101
申请日：2017-02-16
Applicant: Novartis AG
Inventor： Frank Chang , Troy Vernon Holland , Xinming Qian , Robert Scott , Joseph Michael Lindacher , Uwe Haken
CPC classification number: C08F2/48 , A61F2/16 , A61F2002/16965 , A61F2240/001 , G02B1/043 , C08L83/04 , C08L101/14 , C08L83/10
Abstract: The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens.
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Patent Agency Ranking
6.发明申请METHOD FOR PRODUCING CONTACT LENSES WITH DURABLE LUBRICIOUS COATINGS THEREON 有权用于制造具有耐久性润滑涂层的接触镜片的方法公开(公告)号：US20170068019A1
公开(公告)日：2017-03-09
申请号：US15249587
申请日：2016-08-29
Applicant: Novartis AG
Inventor： Xinming Qian , Frank Chang , Yasuo Matsuzawa , Venkat Shankar
CPC classification number: G02B1/043 , B29D11/00048 , B29D11/00067 , B29D11/00125 , C08J7/123 , C08J2383/08 , C08J2433/02 , C08J2471/00 , C08J2477/00
Abstract: The invention is related to a method for producing silicone hydrogel contact lenses with a stable lubricious hydrogel coating thereon. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon.
Abstract translation: 本发明涉及一种在其上具有稳定的润滑性水凝胶涂层的硅酮水凝胶隐形眼镜的制造方法。 本发明的方法包括在硅氧烷水凝胶隐形眼镜上形成具有反应性官能团的等离子体反应性亲水聚合物混合基底涂层，并将该硅酮水凝胶隐形眼镜与混合基底涂层在水溶性和热交联性水溶液中加热 亲水性聚合物材料，以在其上形成稳定的润滑性水凝胶涂层。
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公开(公告)号：US09507173B2
公开(公告)日：2016-11-29
申请号：US14962354
申请日：2015-12-08
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US10449740B2
公开(公告)日：2019-10-22
申请号：US15376708
申请日：2016-12-13
Applicant: Novartis AG
Inventor： Xinming Qian , Jared Nelson , Robert Carey Tucker , Steve Yun Zhang , Daqing Wu , Leroy Wainaina Muya , Dharmesh Patel , Zach Munoz , Yongxing Qiu , Chung-Yuan Chiang , Ritu Shrestha , Kelly Kayi Tallau
IPC: B29D11/00 , G02B1/04 , G02C7/04 , B29K83/00 , B29K105/00
Abstract: The present invention generally relates to a method for producing silicone hydrogel contact lenses having a stable lubricious coating thereon without involving use of organic solvent in post-curing processes.
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公开(公告)号：US20190177444A1
公开(公告)日：2019-06-13
申请号：US16280081
申请日：2019-02-20
Applicant: Novartis AG
Inventor： Frank Chang , Troy Vernon Holland , Xinming Qian , Robert Scott , Joseph Michael Lindacher , Uwe Haken
Abstract: The invention is related to a method for producing silicone medical devices, in particular, silicone contact lenses, having consistent mechanical properties in a cost-effective manner. The invention is also related to a silicone medical device, especially a soft silicone contact lens.
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公开(公告)号：US10308835B2
公开(公告)日：2019-06-04
申请号：US15646291
申请日：2017-07-11
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , G02B1/04 , G02C7/04 , G02B1/10 , G02B1/18 , C08J7/04 , B29D11/00 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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