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公开(公告)号：US10913224B2
公开(公告)日：2021-02-09
申请号：US16181763
申请日：2018-11-06
Applicant: Novartis AG
Inventor： John Dallas Pruitt , Lynn Cook Winterton , Jared Nelson
Abstract: The invention relates to a soft hydrogel contact lens, especially a silicone hydrogel contact lens, which has a capability of delivering a hydrophobic comfort agent into the eye of a wearer. The hydrophobic comfort agent includes without limitation a monoglyceride, a diglyceride, a triglyceride, a glycolipid, a glyceroglycolipid, a sphingolipid, a sphingo-glycolipid, a phospholipid, a fatty acid, a fatty alcohol, a hydrocarbon having a C12-C28 chain in length, a mineral oil, a silicone oil, or a mixture thereof. It can be released from the soft hydrogel contact lens into the eye of a wearer when being worn so as to strengthen and stabilize the tear film lipid layer and alleviate the dryness of the eye.
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公开(公告)号：US09507173B2
公开(公告)日：2016-11-29
申请号：US14962354
申请日：2015-12-08
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US09348061B2
公开(公告)日：2016-05-24
申请号：US14102723
申请日：2013-12-11
Applicant: Novartis AG
Inventor： John Dallas Pruitt , Lynn Cook Winterton
CPC classification number: G02B1/043 , A61K9/0048 , A61L12/04 , B29D11/00067
Abstract: The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.
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公开(公告)号：US20140096484A1
公开(公告)日：2014-04-10
申请号：US14102723
申请日：2013-12-11
Applicant: Novartis AG
Inventor： John Dallas Pruitt , Lynn Cook Winterton
IPC: G02B1/04
CPC classification number: G02B1/043 , A61K9/0048 , A61L12/04 , B29D11/00067
Abstract: The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.
Abstract translation: 本发明涉及改进的隐形眼镜产品，其不仅具有初始插入舒适性，而且佩戴舒适时间超过约6小时。 本发明通过将包含两种或更多种可浸出的聚合润滑剂的水凝胶透镜包装并储存在包含相对低分子量聚乙二醇（PEG）和增粘亲水性聚合物的相对粘稠的包装溶液中来实现。 本发明还提供了制造本发明隐形眼镜产品的方法。
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公开(公告)号：US10308835B2
公开(公告)日：2019-06-04
申请号：US15646291
申请日：2017-07-11
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , G02B1/04 , G02C7/04 , G02B1/10 , G02B1/18 , C08J7/04 , B29D11/00 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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Patent Agency Ranking
公开(公告)号：US08944592B2
公开(公告)日：2015-02-03
申请号：US13948206
申请日：2013-07-23
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
Abstract translation: 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。
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公开(公告)号：US10920102B2
公开(公告)日：2021-02-16
申请号：US16720932
申请日：2019-12-19
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , B29D11/00 , G02B1/18 , G02B1/04 , G02C7/04 , G02B1/10 , C08J7/04 , C08L83/04 , C08G77/388 , C08J5/00 , C09D5/16 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20170306178A1
公开(公告)日：2017-10-26
申请号：US15646291
申请日：2017-07-11
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC: C09D177/06 , B29D11/00 , C08G77/388 , C08J5/00 , C08J7/04 , C08L83/04 , G02B1/18 , G02C7/04 , G02B1/10 , G02B1/04 , C09D171/02 , C09D133/26 , C09D133/14 , C09D133/02 , C09D5/16
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20150099822A1
公开(公告)日：2015-04-09
申请号：US14571350
申请日：2014-12-16
Applicant: Novartis AG
Inventor： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo Norberto Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC classification number: C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
Abstract translation: 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。
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10.发明申请公开(公告)号：US20140112994A1
公开(公告)日：2014-04-24
申请号：US14135666
申请日：2013-12-20
Applicant: Novartis AG
Inventor： Michael F. Rubner , Sung Yun Yang , Yongxing Qiu Qiu , Lynn Cook Winterton , John Martin Lally
CPC classification number: A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
Abstract: The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO− groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
Abstract translation: 本发明提供了一种在医疗装置上制备具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包括至少一层带负电荷的聚离子材料层， 通过还原与带负电荷的聚离子材料的-COO-基团相关联的Ag +离子形成的-COOAg基团和/或银纳米颗粒。 此外，本发明提供了根据本发明的方法制备的医疗装置。
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