公开(公告)号：WO2004112574A3

公开(公告)日：2004-12-29

申请号：PCT/US2004/018984

申请日：2004-06-16

Applicant: OPTIX LP ,  BLOCK, Myron, J.

Inventor： BLOCK, Myron, J.

IPC: G01N21/55

Abstract: The present invention relates to a method and apparatus that utilizes a reflective enclosure (10) to stimulate optical homogeneity in an otherwise inhomogeneous sample. The illumination sources (20) and sample are placed within the reflective enclosure (10), thus providing a method for examining a sample that is different from transmission, reflection or transflection. This apparatus and method are particularly well adapted to in vivo non-invasive testing for constituents of blood.

公开(公告)号：DE69530284T2

公开(公告)日：2004-01-29

申请号：DE69530284

申请日：1995-01-09

Applicant: OPTIX LP

Inventor： BLOCK MYRON J ,  SODICKSON LESTER

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of analytes such as glucose has been developed. The apparatus and methods of the invention exploit analogies with colorimetry and color perception to extract concentration measurements from the global structure of the intensity versus wavelength absorbance or transmission profile. A plurality of broad spectrum filters transmit distinguishably coded beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interferometer can be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by analogy to colorimetry and visual processing and can be converted into concentration measurements.

公开(公告)号：CA2369793A1

公开(公告)日：2000-10-26

申请号：CA2369793

申请日：2000-04-20

Applicant: OPTIX LP

Inventor： GUTHERMANN HOWARD E

IPC: A61B5/0245 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495

Abstract: The absence of a defined optical path length for in vivo measurements create s problems for the noninvasive measurement of analyte concentration. These problems can be reduced by combining measurements made at several wavelength s and using the fact that normal renal function causes the concentration of water in whole blood to be tightly controlled. Hence, the concentration of water in arterial blood can serve as a useful internal standard for such measurements. The measurements are then procured so as to remove the dependency of concentration on path length traversed by the illuminating radiation and on the scattering properties of the volume through which the illuminating radiation propagates. Using this method, one can create improve d calibration for measurements of absorbing constituents in arterial blood and thereby provide absolute concentration measurements of constituents such as hemoglobin and glucose in arterial blood.

公开(公告)号：AU715201B2

公开(公告)日：2000-01-20

申请号：AU5382696

申请日：1996-04-02

Applicant: OPTIX LP

Inventor： BLOCK MYRON J ,  SODICKSON LESTER

IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B10/00 ,  G01N21/31 ,  G01N21/47 ,  G01N21/49 ,  G01N33/487 ,  A61B6/00

Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed.

公开(公告)号：WO2004112574A2

公开(公告)日：2004-12-29

申请号：PCT/US2004/018984

申请日：2004-06-16

Applicant: OPTIX LP ,  BLOCK, Myron, J.

Inventor： BLOCK, Myron, J.

IPC: A61B

CPC classification number: A61B5/6826 ,  A61B5/14552 ,  A61B5/6838 ,  G01N21/01

Abstract: The present invention relates to a method and apparatus that utilizes a reflective enclosure (10) to stimulate optical homogeneity in an otherwise inhomogeneous sample. The illumination sources (20) and sample are placed within the reflective enclosure (10), thus providing a method for examining a sample that is different from transmission, reflection or transflection. This apparatus and method are particularly well adapted to in vivo non-invasive testing for constituents of blood.

Abstract translation: 本发明涉及一种使用反射罩（10）来刺激非均匀样品中的光学均匀性的方法和装置。 照明源（20）和样品被放置在反射罩（10）内，从而提供了用于检查不同于透射，反射或透射的样品的方法。 该装置和方法特别适用于血液成分的体内非侵入性测试。

公开(公告)号：WO2004010138A1

公开(公告)日：2004-01-29

申请号：PCT/US2003/017132

申请日：2003-05-30

Applicant: OPTIX LP ,  GUTHERMANN, Howard, E.

Inventor： GUTHERMANN, Howard, E.

IPC: G01N33/48

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  G01N21/359 ,  G01N21/49

Abstract: A non-invasive detection method for glucose and other constituents of interest in a sample is described. The apparatus and methods of the invention is based on an analog of color perception of human vision, preferably in the near infrared region, replacing the spectrometers used in other non-invasive near infrared detection methods. The sample is illuminated with broad spectrum illumination (104) and radiation form the sample is detected (106) using a plurality of detection units, each covering a broad region of the detected spectrum. A vector is generated from the detected radiation (108) and a correction vector obtained from a standard (100, 102, 109) is used with the detected vector to determine analyte concentration (110) using calibration based upon the results of in vitro measurements. A neutral network can be used for analysis, allowing the system to learn.

Abstract translation: 描述了样品中葡萄糖和其它感兴趣成分的非侵入性检测方法。 本发明的装置和方法基于人类视觉的颜色感知的模拟，优选地在近红外区域中，代替其它非侵入式近红外检测方法中使用的光谱仪。 用广谱照明（104）照射样品，并且使用多个检测单元检测样品的辐射（106），每个检测单元覆盖检测到的光谱的宽区域。 从检测到的辐射（108）产生载体，并且使用从标准物（100,102,109）获得的校正载体与所检测的载体一起使用基于体外测量结果的校准来确定分析物浓度（110）。 中立网络可用于分析，允许系统学习。

公开(公告)号：WO1996039922A1

公开(公告)日：1996-12-19

申请号：PCT/US1996004502

申请日：1996-04-02

Applicant: OPTIX LP

Inventor： OPTIX LP ,  BLOCK, Myron, J. ,  SODICKSON, Lester

IPC: A61B05/00

CPC classification number: A61B5/14532 ,  A61B5/0059 ,  A61B5/14546 ,  A61B5/14558 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/3137

Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed. In a second embodiment the detector collects only polarized radiation while excluding depolarized (multiple scattered) radiation. The radiation preferrably is chosen to be in the 700-1500 nm wavelength range. The sample preferrably is a portion of a mammalian body, the analyte to be analyzed is selected from the group consisting of glucose, glucose identifying substances, mixtures thereof or from the group consisting of hemoglobin, deoxyhemoglobin and mixtures thereof. The concentration measurement can be used to derive oxygen saturation of the blood.

Abstract translation: 已经开发了用于样品中浓度的光学测试的改进的方法和装置。 该装置限制了立体照明角度和立体检测角度，以消除散射辐射的高比例，同时允许弹道辐射和蛇状辐射传播。 在包含多个散射中心的样品中，这样可有效地校正光束长度的变化，并允许更容易校准仪器。 还公开了使用偏振辐射作为使样品中的散射辐射最小化的手段。 在第二实施例中，检测器仅收集偏振辐射，同时排除去极化（多散射）辐射。 辐射优选地选择在700-1500nm波长范围内。 样品优选地是哺乳动物体的一部分，待分析的分析物选自葡萄糖，葡萄糖鉴定物质，其混合物或由血红蛋白，脱氧血红蛋白及其混合物组成的组。 浓度测量可用于导出血液的氧饱和度。

公开(公告)号：CA2180128C

公开(公告)日：2004-06-29

申请号：CA2180128

申请日：1995-01-09

Applicant: OPTIX LP

Inventor： SODICKSON LESTER ,  BLOCK MYRON J

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/35 ,  G01N21/47 ,  G01N21/61 ,  G01N33/487

Abstract: A new non-invasive non-spectrophotometric method for measuring the blood concentration of ana- lytes such as glucose has been developed. A plurality of broad spectrum filters (30A-30D) transmit distin- guishably coded by choppers (20A-20D) beams of radiation in overlapping portions of the spectrum to the sample. Radiation reflected or transmitted by the sample is detected and decoded. LED's may be used instead of the broad spectrum radiation generating device and the filters. Further, a scanning interfer- ometer cam be used as the illuminating and coding device. In a preferred mode, congruent illumination is utilized. The coded signals are analyzed by anal- ogy to colorimetry and visual processing and can be converted into concentration measurements.

公开(公告)号：AU5382696A

公开(公告)日：1996-12-30

申请号：AU5382696

申请日：1996-04-02

Applicant: OPTIX LP

Inventor： BLOCK MYRON J ,  SODICKSON LESTER

IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B10/00 ,  G01N21/31 ,  G01N21/47 ,  G01N21/49 ,  G01N33/487

Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed.

公开(公告)号：CA2223408A1

公开(公告)日：1996-12-19

申请号：CA2223408

申请日：1996-04-02

Applicant: OPTIX LP

Inventor： SODICKSON LESTER ,  BLOCK MYRON J

IPC: G01N21/35 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B10/00 ,  G01N21/31 ,  G01N21/47 ,  G01N21/49 ,  G01N33/487 ,  A61B6/00

Abstract: An improved method and apparatus for use in optical testing of concentration in samples has been developed. The apparatus restricts the solid angle of illumination and the solid angle of detection to eliminate a high proportion of the scattered radiation while allowing the ballistic radiation and the snake-like radiation to be transmitted. In samples which contain multiple scattering centers, this allows less correction for variations in effective pathlength and allows easier calibration of the apparatus. The use of polarized radiation as a means of minimizing scattered radiation in the sample is also disclosed. In a second embodiment the detector collects only polarized radiation while excluding depolarized (multiple scattered) radiation. The radiation preferrably is chosen to be in the 700-1500 nm wavelength range. The sample preferrably is a portion of a mammalian body, the analyte to be analyzed is selected from the group consisting of glucose, glucose identifying substances, mixtures thereof or from the group consisting of hemoglobin, deoxyhemoglobin and mixtures thereof. The concentration measurement can be used to derive oxygen saturation of the blood.