公开(公告)号：WO2010050783A2

公开(公告)日：2010-05-06

申请号：PCT/KR2009/006357

申请日：2009-10-30

Applicant: 서울대학교산학협력단 ,  강헌중 ,  노정래 ,  홍정호 ,  박승범 ,  신찬수 ,  이재환 ,  홍준영 ,  김은오 ,  김정아 ,  오상미

Inventor： 강헌중 ,  노정래 ,  홍정호 ,  박승범 ,  신찬수 ,  이재환 ,  홍준영 ,  김은오 ,  김정아 ,  오상미

IPC: C07D493/10 ,  C07D493/04 ,  C07D493/02 ,  A61K31/35 ,  A61K31/36 ,  A61P19/10

CPC classification number: C07D493/10

Abstract: 본 발명은 스파이로키랄 탄소 골격을 갖는 신규한 화합물, 그의 입체이성질체, 그의 거울상이성질체, 생체 내에서 가수분해 가능한 그의 전구체 또는 약제학적으로 허용 가능한 그의 염을 제공한다. 상기 스파이로키랄 탄소 골격을 갖는 신규한 화합물은 조골세포 분화능이 우수하며, 비만세포 분화억제능 및 간에서의 지방산 합성 억제능을 가지므로, 골다공증, 지방간 및 비만치료에 획기적인 역할을 할 것으로 기대된다.

Abstract translation:

本发明提供了新颖的化合物，它们的立体异构体，其对映体，其在体内可水解前体，或具有间谍洛基LAL碳骨架的药物上可接受的盐。 具有间谍洛基LAL碳骨架和成骨细胞多能的新化合物是优异的，因为的肥大细胞分化的抑制能力的脂肪酸合成的抑制能力，和肝，预计是在骨质疏松症，脂肪肝和肥胖症的一个创新的作用。< / p>

公开(公告)号：KR1020100048934A

公开(公告)日：2010-05-11

申请号：KR1020090104124

申请日：2009-10-30

Applicant: 서울대학교산학협력단

Inventor： 강헌중 ,  노정래 ,  홍정호 ,  박승범 ,  신찬수 ,  이재환 ,  홍준영 ,  김은오 ,  김정아 ,  오상미

IPC: C07D493/10 ,  C07D493/02 ,  A61K31/435 ,  A61P3/04

CPC classification number: C07D493/10

Abstract: PURPOSE: A novel compound having spiro chiral carbon skeleton is provided to suppress mastocyte differentiation and fatty acid synthesis and use in treating osteoporosis, fatty liver, and obesity. CONSTITUTION: A novel compound having spiro chiral carbon skeleton is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 comprises: a step of cutting and drying Phorbas sp. and extracting with C1-C4; a step of dividing the extracting with water and methylene chloride to remove solvent of organic layer; a step of distributing with mixture solution of normal hexane, methanol, and water; a step of removing solvent of methanol layer; and a step of performing chromatography to obtain fraction.

Abstract translation: 目的：提供一种具有螺状手性碳骨架的新型化合物，用于抑制肥大细胞分化和脂肪酸合成，并用于治疗骨质疏松症，脂肪肝和肥胖症。 构成：具有螺状手性碳骨架的新化合物由化学式1表示。化学式1化合物的制备方法包括：切割并干燥佛波斯 并用C1-C4提取; 用水和二氯甲烷分离提取物以除去有机层的溶剂的步骤; 用正己烷，甲醇和水的混合溶液分配的步骤; 去除甲醇层溶剂的步骤; 以及进行色谱以获得级分的步骤。

公开(公告)号：KR101149878B1

公开(公告)日：2012-05-24

申请号：KR1020090104124

申请日：2009-10-30

Applicant: 서울대학교산학협력단

Inventor： 강헌중 ,  노정래 ,  홍정호 ,  박승범 ,  신찬수 ,  이재환 ,  홍준영 ,  김은오 ,  김정아 ,  오상미

IPC: C07D493/10 ,  C07D493/02 ,  A61K31/435 ,  A61P3/04

CPC classification number: C07D493/10

Abstract: Provided are a novel compound with a spiro chiral carbon backbone, a stereoisomer thereof, an enantiomer thereof, an in vivo hydrolysable precursor thereof, or a pharmaceutically acceptable salt thereof. The novel compound with the spiro chiral carbon backbone has excellent osteoblast differentiation activity, mast cell inhibitoryactivity, and fatty acid synthesis inhibitory activity in the liver. Therefore, the novel compound can be expected to play an innovative role in treatment of osteoporosis, fatty liver, and obesity.

公开(公告)号：KR100977638B1

公开(公告)日：2010-08-24

申请号：KR1020100013913

申请日：2010-02-16

Applicant: 서울대학교산학협력단

Inventor： 정해진 ,  박재연 ,  유영두 ,  강남선 ,  노정래

IPC: C12P7/04 ,  C12N1/12 ,  C12N1/10 ,  C12R1/89

CPC classification number: C12P7/649 ,  C12N1/10 ,  C12N1/12 ,  Y02E50/13

Abstract: PURPOSE: A method for removing greenhouse gas and producing bioenergy is provided to produce environmentally-friendly energy. CONSTITUTION: A method for removing greenhouse gas and producing bioenergy comprises: a step of selecting aquatic plants and predator; a step of supplying gas mixture to the aqueous plant for intake of greenhouse gas by the aquatic plants; a step of removing greenhouse gas and culturing the aquatic plants; a step of providing the aquatic plant for the predator to remove the aquatic plant; a step of increasing the predator; a step of collecting the increased predator; and a step of converting the predator to bioenergy.

Abstract translation: 目的：提供一种消除温室气体和生产生物能源的方法，以产生环保能源。 构成：消除温室气体和生产生物能的方法包括：选择水生植物和捕食者的步骤; 向含水植物提供气体混合物以供水生植物摄取温室气体的步骤; 消除温室气体和培养水生植物的一个步骤; 为捕食者提供水生植物去除水生植物的一个步骤; 增加捕食者的一步; 收集增加的捕食者的步骤; 并将捕食者转化为生物能源的步骤。