公开(公告)号：KR1020090014428A

公开(公告)日：2009-02-11

申请号：KR1020070077882

申请日：2007-08-02

Applicant: 성균관대학교산학협력단

Inventor： 홍성렬 ,  권무식 ,  이충은 ,  조재열 ,  김서영

IPC: A61K38/08 ,  A61P35/00

CPC classification number: A61K38/12 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K2039/585

Abstract: An anti-cancer composition comprising surfactin is provided to inhibit the cell proliferation, and the proliferation of the human colon carcinoma cell by inducing pro-apoptotic activity and suppressing the differentiation and proliferation of LoVo cell by inhibiting cell cycle. The composition for treating cancer comprises surfactin and further comprises the pharmaceutically acceptable carrier selected from diluent, lubricant, binder, disintegrant, sweetener, stabilizer and antiseptic, and additive selected from perfume and vitamin B.

Abstract translation: 提供包含表面活化素的抗癌组合物，通过诱导促凋亡活性并通过抑制细胞周期抑制LoVo细胞的分化和增殖来抑制细胞增殖和人结肠癌细胞的增殖。 用于治疗癌症的组合物包括表面活性素，并且还包含选自稀释剂，润滑剂，粘合剂，崩解剂，甜味剂，稳定剂和防腐剂的药学上可接受的载体，以及选自香料和维生素B的添加剂。

公开(公告)号：KR100841207B1

公开(公告)日：2008-06-24

申请号：KR1020070009776

申请日：2007-01-31

Applicant: 성균관대학교산학협력단

Inventor： 권무식 ,  신우석 ,  한보람

IPC: C12N15/66 ,  C12N15/63 ,  C12N15/09

CPC classification number: A61K39/102 ,  A61K2039/53 ,  A61K2039/552

Abstract: A peptide vaccine using an outer membrane protein H(OmpH) of Pasteurella multocida is provided to be used for preparing a vaccine which shows excellent activity and is applicable into the body through various pathways. A vaccine for preventing and treating porcine atrophic rhinitis comprises a total or a portion of a recombinant outer membrane protein H of a Pasteurella multocida(D:4) strain expressed from a recombinant expression vector including a gene having at least one sequence of SEQ ID : NO. 7, SEQ ID : NO. 8, SEQ ID : NO. 9, SEQ ID : NO. 10 and SEQ ID : NO. 11 encoding a total or a portion of an OmpH of the Pasteurella multocida(D:4) strain or a pharmaceutically acceptable carrier.

Abstract translation: 提供一种使用多巴斯巴斯服务的外膜蛋白H（OmpH）的肽疫苗，用于制备显示出优异活性并通过各种途径适用于人体的疫苗。 用于预防和治疗猪萎缩性鼻炎的疫苗包含由重组表达载体表达的巴斯德毕赤酵母（D：4）菌株的重组外膜蛋白H的全部或部分，所述重组表达载体包含具有至少一个SEQ ID： 没有。 7，SEQ ID NO： 8，SEQ ID NO： 9，SEQ ID NO： 10和SEQ ID NO： 11编码整个或一部分多杀巴斯德氏菌（D：4）菌株的OmpH或药学上可接受的载体。

公开(公告)号：KR1020090034131A

公开(公告)日：2009-04-07

申请号：KR1020070099331

申请日：2007-10-02

Applicant: 성균관대학교산학협력단

Inventor： 권무식 ,  홍성렬 ,  조재열

IPC: C12N15/64 ,  C12N15/09

Abstract: A transgenic potato is provided to produce mistletoe lectin by using mistletoe lectin with a gene of the mistletoe lectin and to produce the mistletoe lectin having anti-cancer and immune enhancing effects massively. A recombinant plant expression vector includes a gene inserted by operation of 2 of a sequence number encoding Korean mistletoe lectin protein. A transgenic potato is acquired by transforming the potato into the recombinant plant expression vector by using the agrobacterium. A composition for treating cancer includes the Korean mistletoe lectin protein from the recombinant plant expression vector.

Abstract translation: 提供转基因马铃薯，通过使用槲寄生凝集素与槲寄生凝集素的基因产生槲寄生凝集素，并大量生产具有抗癌和免疫增强作用的槲寄生凝集素。 重组植物表达载体包括通过操作2个编码韩国槲寄生凝集素蛋白的序列号插入的基因。 通过使用农杆菌将马铃薯转化成重组植物表达载体获得转基因马铃薯。 用于治疗癌症的组合物包括来自重组植物表达载体的韩国槲寄生凝集素蛋白。

公开(公告)号：KR100829380B1

公开(公告)日：2008-05-13

申请号：KR1020060134798

申请日：2006-12-27

Applicant: 성균관대학교산학협력단

Inventor： 권무식 ,  정기용

IPC: C12N15/64 ,  C12N15/09

Abstract: A fowl cholera vaccine composition is provided to enhance immune responses against infection of Pasteurella multocida causing fowl cholera by using a recombinant outer membrane protein H of Pasteurella multocida. A gene(OmpH) encoding a recombinant outer membrane protein H(OmpH) of Pasteurella multocida A:3, wherein a gene encoding a leader protein is deleted(NCBI Genbank No. DQ054529), is isolated and sequenced. A fowl cholera vaccine composition comprises a recombinant outer membrane protein H(OmpH) of Pasteurella multocida A:3 expressed from a recombinant expression vector containing an operatively inserted OmpH gene(NCBI Genbank No. DQ054529) or pharmaceutically acceptable carriers.

Abstract translation: 提供家禽霍乱疫苗组合物，以通过使用多杀巴斯德氏菌的重组外膜蛋白H来增强针对引起家禽霍乱的多杀巴斯德氏杆菌感染的免疫应答。 分离编码编码前导蛋白的基因（NCBI Genbank No.DD054529）的多巴巴杆菌A：3的重组外膜蛋白H（OmpH）的基因（OmpH），并进行测序。 家禽霍乱疫苗组合物包含由含有可操作地插入的OmpH基因（NCBI Genbank编号DQ054529）或药学上可接受的载体的重组表达载体表达的多杀巴斯德氏菌A：3的重组外膜蛋白H（OmpH）。