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公开(公告)号：KR101415985B1
公开(公告)日：2014-07-08
申请号：KR1020120030145
申请日：2012-03-23
Applicant: 전남대학교병원
Abstract: 본 발명은 세포내 유전자 전달용 복합체 및 이를 이용한 유전자 전달체에 관한 것으로, 상기 본 발명에 따른 세포내 유전자 전달용 복합체는 유전자를 종양 세포에 안전하고 효율적으로 전달할 수 있으며, 상기 세포내 유전자 전달용 복합체에 항암 효과가 있는 다양한 유전자를 결합시켜 종양과 관련된 질병 또는 질환의 치료에 유용하게 사용될 수 있을 것이다.
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公开(公告)号：KR1020130107943A
公开(公告)日：2013-10-02
申请号：KR1020120030145
申请日：2012-03-23
Applicant: 전남대학교병원
CPC classification number: A61K48/00 , A23V2200/308 , A61K47/30
Abstract: PURPOSE: A composite for intracellular gene delivery is provided to safely and efficiently deliver a gene to tumor cells and to treat tumor-associated diseases or disorders by binding various genes with anticancer effects. CONSTITUTION: A composite for intracellular gene delivery contains: polyethylene imine which is activated by being conjugated with succinimidyl 4-(N-maleimido-methyl)cyclohexane-1-carboxylate (SMCC); cell penetrating peptides; and tris(2-carboxyethyl)phosphine (TCEP). An anti-tumor composition contains the composite and nucleic acids. The nucleic acids are selected among gDNA, cDNA, pDNA, mRNA, tRNA, rRNA, siRNA, miRNA, and antisense nucleotides.
Abstract translation: 目的：提供用于细胞内基因递送的复合物，以安全有效地将基因递送到肿瘤细胞，并通过结合具有抗癌作用的各种基因来治疗肿瘤相关疾病或病症。 构成：用于细胞内基因递送的复合物包含：通过与4-（N-马来酰亚氨基 - 甲基）环己烷-1-羧酸琥珀酰亚胺酯（SMCC）缀合而活化的聚乙烯亚胺; 细胞穿透肽 和三（2-羧乙基）膦（TCEP）。 抗肿瘤组合物含有复合物和核酸。 核酸选自gDNA，cDNA，pDNA，mRNA，tRNA，rRNA，siRNA，miRNA和反义核苷酸。
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公开(公告)号：KR1020130103396A
公开(公告)日：2013-09-23
申请号：KR1020130024276
申请日：2013-03-07
Applicant: 전남대학교병원
CPC classification number: A61K49/1863 , A61K49/08 , A61K49/1875 , B82Y40/00
Abstract: PURPOSE: A magnetic resonance imaging (MRI) contrast agent coated with beta-glucan is provided to effectively allow immunocytes to enter, thereby distinguishing a lesion and a normal tissue in a tissue containing immunocytes through MRI. CONSTITUTION: A method for manufacturing MRI contrast agent comprises the steps of: synthesizing superparamagnetic nanoparticles; oxidizing and dialyzing the superparamagnetic nanoparticles and preparing a superparamagnetic storage solution; diluting the storage solution with distilled water and dropping a beta-glucan solution at 1-10°C; and adding a basic solution to the reactant and adjusting the pH concentration of the reactant.
Abstract translation: 目的：提供涂有β-葡聚糖的磁共振成像（MRI）造影剂，以有效地使免疫细胞进入，从而通过MRI区分含有免疫细胞的组织中的病变和正常组织。 构成：制造MRI造影剂的方法包括以下步骤：合成超顺磁性纳米粒子; 氧化和透析超顺磁性纳米颗粒并制备超顺磁性储存溶液; 用蒸馏水稀释储存溶液，并在1-10℃下滴加β-葡聚糖溶液; 并向反应物中加入碱性溶液并调节反应物的pH浓度。
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公开(公告)号：KR101243978B1
公开(公告)日：2013-03-14
申请号：KR1020110011712
申请日：2011-02-10
Applicant: 전남대학교병원
Abstract: 본 발명은 관상동맥용 스텐트에 관한 것으로, 보다 상세하게는 스텐트의 형상을 유지하는 확장부재를 유연한 구조의 연결부재로 연결하여 스텐트의 유연성을 향상시켜 시술의 편의성을 향상시키며, 확장부재의 말단에 복수의 원호가 형성되어 응력이 집중되는 것을 방지하여 혈관벽의 손상을 최소화시킬 수 있는 관상동맥용 스텐트에 관한 것이다.
본 발명에 따른 관상동맥용 스텐트는, 관공을 개방상태로 유지하기 위해 종방향으로 복수개가 배열되고 반경방향으로 확장이 가능한 환상의 확장부재와, 종방향으로 이웃하는 확장부재를 서로 종방향으로 연결하는 연결부재를 포함하는 관상동맥용 스텐트에 있어서, 상기 확장부재는 종방향으로 서로 평행한 복수의 직선부와, 이웃하는 직선부의 종방향의 양측 말단을 교대로 연결하는 연결부로 구성되며, 상기 연결부재는 그 일측 말단이 이웃하는 확장부재 중 하나의 직선부의 양단부 사이의 소정 위치에서 연결되고, 타측 말단이 이웃하는 확장부재 중 다른 하나의 직선부의 양단부 사이의 소정 위치에서 연결된 것을 특징으로 한다.-
公开(公告)号：KR101178793B1
公开(公告)日：2012-08-31
申请号：KR1020110027886
申请日：2011-03-29
CPC classification number: A61F2/82 , A61F2240/001 , A61F2250/0067 , A61F2310/00011 , A61F2310/00976 , A61L31/022 , A61L31/10 , A61L31/16
Abstract: PURPOSE: A method for coating heparin on the surface of a stent is provided to maintain a blood clot coagulation effect by improving heparin attachment stability. CONSTITUTION: A method for coating heparin on the surface of a stent is as follows. A coating solution is prepared by adding EDC(1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride) and NHS(N-hydroxysulfosuccinimide) to a mixture solution of heparin and dopamine. A metal stent is dipped in the coating solution. The metal stent is made of a material selected from a group consisting of stainless steel, Co-Cr alloy, tantalum, and gold.
Abstract translation: 目的：提供一种在支架表面涂覆肝素的方法，以通过改善肝素附着稳定性来维持凝血凝血作用。 构成：在支架表面涂覆肝素的方法如下。 通过将EDC（1-乙基-3-（3-二甲基氨基丙基）碳二亚胺盐酸盐）和NHS（N-羟基磺基琥珀酰亚胺）加入到肝素和多巴胺的混合溶液中来制备涂布溶液。 将金属支架浸入涂布溶液中。 金属支架由选自不锈钢，Co-Cr合金，钽和金的材料制成。
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Patent Agency Ranking
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公开(公告)号：KR1020120091744A
公开(公告)日：2012-08-20
申请号：KR1020110011713
申请日：2011-02-10
Applicant: 전남대학교병원
IPC: A61F2/82 , A61L27/28 , A61L27/54 , A61K31/727
CPC classification number: A61F2/82 , A61F2240/001 , A61F2250/0067 , A61F2310/00976 , A61L31/10 , A61L31/16
Abstract: PURPOSE: A method for coating heparin on the surface of a stent is provided to improve the stability heparin on the surface of a stent based on the chemical bond of dopamine and the heparin. CONSTITUTION: A method for coating heparin on the surface of a stent includes the following: heparin and dopamine are synthesized, and a solution with the dissolved synthesized product is prepared; and the solution is applied on the surface of a metal-based stent such that the heparin is coated on the surface of the stent. The molar ratio of the heparin and the dopamine is 1:1.2-1.5. The coating process is based on an immersing process or a spraying process. The stent is immersed in the synthesized product dissolved solution, or the synthesized product dissolved solution is sprayed on the stent.
Abstract translation: 目的：提供一种在支架表面涂覆肝素的方法，以改善基于多巴胺和肝素化学键的支架表面稳定性肝素。 构成：在支架表面涂覆肝素的方法包括以下：合成肝素和多巴胺，制备溶解合成产物的溶液; 并将溶液施加到金属基支架的表面上，使得肝素被涂覆在支架的表面上。 肝素和多巴胺的摩尔比为1:1.2-1.5。 涂覆工艺基于浸渍工艺或喷涂工艺。 将支架浸入合成产物溶解溶液中，或将合成产物溶解的溶液喷涂在支架上。
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公开(公告)号：KR1020120072293A
公开(公告)日：2012-07-03
申请号：KR1020110011712
申请日：2011-02-10
Applicant: 전남대학교병원
CPC classification number: A61F2/915 , A61F2/07 , A61F2002/826 , A61F2002/828 , A61F2250/0012 , A61M29/00
Abstract: PURPOSE: A stent for coronary artery is provided to minimize the damage to the wall of blood vessel and to improve the flexibility of the stent. CONSTITUTION: A stent for coronary artery comprises an expansion member(11) and connecting members(12,12'). A plurality of the expansion members is arranged in the longitudinal direction and is formed in the structure of a frame in order to be extended in the radial direction. The connecting member is formed to be connected to the center of the expansion member and improves the flexibility of the stent.
Abstract translation: 目的：提供用于冠状动脉的支架以最小化对血管壁的损伤并改善支架的柔性。 构成：冠状动脉支架包括扩张构件（11）和连接构件（12,12'）。 多个膨胀构件沿长度方向布置并且形成在框架的结构中以便沿径向方向延伸。 连接构件形成为连接到膨胀构件的中心并且改善了支架的柔性。
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