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公开(公告)号：WO2007140385A3
公开(公告)日：2007-12-06
申请号：PCT/US2007/069921
申请日：2007-05-30
Applicant: ABBOTT LABORATORIES , DART, Michael J. , CARROLL, William A. , FLORJANCIC, Alan S. , FROST, Jennifer M. , GALLAGHER, Megan E. , LI, Tongmei , NELSON, Derek W. , PATEL, Meena V. , PEDDI, Sridhar , PEREZ-MEDRANO, Arturo , RYTHER, Keith B. , TIETJE, Karin Rosemarie , KOLASA, Teodozyj
Inventor： DART, Michael J. , CARROLL, William A. , FLORJANCIC, Alan S. , FROST, Jennifer M. , GALLAGHER, Megan E. , LI, Tongmei , NELSON, Derek W. , PATEL, Meena V. , PEDDI, Sridhar , PEREZ-MEDRANO, Arturo , RYTHER, Keith B. , TIETJE, Karin Rosemarie , KOLASA, Teodozyj
IPC: C07D277/46 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61P29/00
Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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公开(公告)号：WO2008063781A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/081263
申请日：2007-10-12
Applicant: ABBOTT LABORATORIES , CARROLL, William A. , DART, Michael J. , KOLASA, Teodozyj , MEYER, Michael D. , PATEL, Meena V. , WANG, Xueqing
Inventor： CARROLL, William A. , DART, Michael J. , KOLASA, Teodozyj , MEYER, Michael D. , PATEL, Meena V. , WANG, Xueqing
IPC: C07D277/26 , C07D277/30 , C07D277/64 , C07D417/06 , C07D277/60 , C07D277/56 , C07D285/12 , C07D513/04 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61K31/433 , A61P25/00 , A61P29/00
Abstract: The present invention relates to compounds of formula (I), wherein A, E, L2, R1, R3, R4 and R5 are as defined in the herein, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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公开(公告)号：WO2010123838A2
公开(公告)日：2010-10-28
申请号：PCT/US2010/031660
申请日：2010-04-20
Applicant: ABBOTT LABORATORIES , PEDDI, Sridhar , PATEL, Meena V. , ROHDE, Jeffrey J.
Inventor： PEDDI, Sridhar , PATEL, Meena V. , ROHDE, Jeffrey J.
IPC: C07C261/04 , C07C257/14 , A61K31/26 , A61P3/10 , A61P25/00
CPC classification number: A61K31/26 , C07C257/14 , C07C257/16 , C07C261/04 , C07C311/46 , C07C317/30 , C07C327/42 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/18 , C07C2602/42 , C07C2602/44 , C07C2603/74 , C07C2603/97 , C07D207/277 , C07D211/14 , C07D213/24 , C07D213/26 , C07D213/74 , C07D231/12 , C07D239/42 , C07D257/04 , C07D261/08 , C07D277/42 , C07D295/14 , C07D307/46 , C07D401/12 , C07D403/12 , C07D417/12
Abstract: The present invention relates to inhibitors of 11- β-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
Abstract translation: 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征，中枢神经系统疾病和疾病和病症中的用途 这与过量的糖皮质激素有关。
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Patent Agency Ranking4.发明申请
公开(公告)号：WO2007140439A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/070029
申请日：2007-05-31
Applicant: ABBOTT LABORATORIES , DART, Michael J. , CARROLL, William A. , FLORJANCIC, Alan S. , FROST, Jennifer M. , GALLAGHER, Megan E. , KOLASA, Teodozyj , LI, Tongmei , NELSON, Derek W. , PATEL, Meena V. , PEDDI, Sridhar , PEREZ-MEDRANO, Arturo , RYTHER, Keith B. , TIETJE, Karin Rosemarie
Inventor： DART, Michael J. , CARROLL, William A. , FLORJANCIC, Alan S. , FROST, Jennifer M. , GALLAGHER, Megan E. , KOLASA, Teodozyj , LI, Tongmei , NELSON, Derek W. , PATEL, Meena V. , PEDDI, Sridhar , PEREZ-MEDRANO, Arturo , RYTHER, Keith B. , TIETJE, Karin Rosemarie
IPC: C07D277/46 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , A61K31/426 , A61K31/427 , A61K31/428 , A61P29/00
CPC classification number: C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and L 2 , are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前体药物，前药盐或其组合，其中R 1，R 2，R 2， 在本说明书中定义了含有这些化合物的组合物，以及使用这些化合物治疗病症和障碍的方法，其中，R 3，R 4， 和组合物。
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公开(公告)号：EP1181296A1
公开(公告)日：2002-02-27
申请号：EP99931986.6
申请日：1999-06-28
Applicant: ABBOTT LABORATORIES
Inventor： ARENDSEN, David, L. , BHATIA, Pramila , BOYD, Steven, A. , CONDROSKI, Kevin, R. , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , LARTEY, Kraig , MCCARTY, Catherine, M. , MORT, Nicholas, A. , PATEL, Meena V. , STAEGER, Michael, A. , STEWART, Andrew, O. , STOUT, David, M. , ZHU, Gui-Dong
IPC: C07D495/04
CPC classification number: C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds having formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗炎症。 还公开了包含式（I）化合物的药物组合物，以及在哺乳动物中抑制/治疗炎性疾病的方法。
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公开(公告)号：EP2024349A2
公开(公告)日：2009-02-18
申请号：EP07797908.6
申请日：2007-05-31
Applicant: ABBOTT LABORATORIES
Inventor： DART, Michael J. , CARROLL, William A. , FLORJANCIC, Alan S. , FROST, Jennifer M. , GALLAGHER, Megan E. , KOLASA, Teodozyj , LI, Tongmei , NELSON, Derek W. , PATEL, Meena V. , PEDDI, Sridhar , PEREZ-MEDRANO, Arturo , RYTHER, Keith B. , TIETJE, Karin Rosemarie
IPC: C07D277/46 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , A61K31/426 , A61K31/427 , A61K31/428 , A61P29/00
CPC classification number: C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前药的盐或其组合，其中R 1，R 2，R 3，R 4和L 2在说明书中定义，包含此类化合物的组合物， 以及使用这样的化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：EP2038266A2
公开(公告)日：2009-03-25
申请号：EP07797862.5
申请日：2007-05-30
Applicant: ABBOTT LABORATORIES
Inventor： DART, Michael J. , CARROLL, William A. , FLORJANCIC, Alan S. , FROST, Jennifer M. , GALLAGHER, Megan E. , LI, Tongmei , NELSON, Derek W. , PATEL, Meena V. , PEDDI, Sridhar , PEREZ-MEDRANO, Arturo , RYTHER, Keith B. , TIETJE, Karin Rosemarie , KOLASA, Teodozyj
IPC: C07D277/46 , C07D277/48 , C07D277/60 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , A61P29/00
CPC classification number: C07D277/82 , C07D277/46 , C07D277/48 , C07D277/60 , C07D417/06 , C07D417/12 , C07D477/14 , C07D513/04
Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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公开(公告)号：EP1090009A2
公开(公告)日：2001-04-11
申请号：EP99926157.1
申请日：1999-06-03
Applicant: ABBOTT LABORATORIES
Inventor： STEWART, Andrew, O. , BOYD, Steven, A. , ARENDSEN, David, L. , BHATIA, Pramila , CONDROSKI, Kevin, R. , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , ZHU, Gui-Dong , LARTEY, Kraig , MCCARTY, Catherine, M. , MORT, Nicholas, A. , PATEL, Meena V. , STAEGER, Michael, A. , STOUT, David, M.
IPC: C07D495/04 , C07D498/04 , C07D513/04 , C07D471/04 , C07D491/04 , A61K31/44 , A61K31/50 , A61K31/505
CPC classification number: C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗炎症。 还公开了包含式（I）化合物的药物组合物，以及在哺乳动物中抑制/治疗炎性疾病的方法。
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