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公开(公告)号：DK2320947T3
公开(公告)日：2015-09-07
申请号：DK09795269
申请日：2009-07-10
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HUEY , YU ALICE , LIN KUN-HSIEN , CHENG EDMOND Y S , JAN JIA-TSRONG , LIN YI-LING , HUNG JUNG-TUNG , CHANG YA-JEN
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公开(公告)号：CA2756053A1
公开(公告)日：2010-01-14
申请号：CA2756053
申请日：2009-07-10
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HUEY , YU ALICE , CHANG YA-JEN , LIN KUN-HSIEN , CHENG Y S EDMOND , JAN JIA-TSRONG , LIN YI-LING , HUNG JUNG-TUNG
Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (.alpha.- GalCer) analogs, and their use as immunotherapies, adju-vants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cy-tokine response in a subject includes administer-ing an effective amount of a compound to a sub-ject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1 :; or a pharmaceutically acceptable salt thereof; forming a complex between the com-pound and the antigen-presenting cell, wherein the formation of the complex results in the activa-tion of a receptor on the lymphocyte; and activat-ing the lymphocyte to produce the cytokine re-sponse.
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3.发明申请ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES, ADJUVANTS, AND INTIVIRAL, ANTIBACTERIAL, AND ANTICANCER AGENTS 审中-公开ALPHA-GALACTOSYL CERAMIDE ANALOGS及其作为免疫抑制剂，调节剂和杀虫剂，抗真菌剂和抗原剂的用途
公开(公告)号：WO2010006315A3
公开(公告)日：2010-03-25
申请号：PCT/US2009050328
申请日：2009-07-10
Applicant: ACADEMIA SINICA , WONG CHI-HUEY , YU ALICE , CHANG YA-JEN , LIN KUN-HSIEN , CHENG Y S EDMOND , JAN JIA-TSRONG , LIN YI-LING , HUNG JUNG-TUNG
Inventor： WONG CHI-HUEY , YU ALICE , CHANG YA-JEN , LIN KUN-HSIEN , CHENG Y S EDMOND , JAN JIA-TSRONG , LIN YI-LING , HUNG JUNG-TUNG
CPC classification number: C07H15/18 , A61K31/7034 , A61K39/0011 , A61K2039/57
Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (a- GalCer) analogs, and their use as immunotherapies, adjuvants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1 :; or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.
Abstract translation: 本公开内容涉及合成的α-半乳糖神经酰胺（a-GalCer）类似物，以及它们作为免疫疗法，佐剂和抗病毒，抗菌和抗癌剂的用途。 一方面，在受试者中激活细胞因子应答的方法包括向受试者施用有效量的化合物，其中所述受试者具有包括细胞群的适应性免疫系统，所述群体包括至少一种淋巴细胞和 至少一种抗原呈递细胞，并且其中所述化合物由式1的结构表示： 或其药学上可接受的盐; 在化合物和抗原呈递细胞之间形成复合物，其中复合物的形成导致淋巴细胞上受体的活化; 并激活淋巴细胞以产生细胞因子反应。
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公开(公告)号：AU2009268381B2
公开(公告)日：2016-04-21
申请号：AU2009268381
申请日：2009-07-10
Applicant: ACADEMIA SINICA
Inventor： HUNG JUNG-TUNG , LIN KUN-HSIEN , YU ALICE , JAN JIA-TSRONG , CHANG YA-JEN , LIN YI-LING , WONG CHI-HUEY , CHENG Y S EDMOND
Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (α- GalCer) analogs, and their use as immunotherapies, adjuvants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1 :; or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.
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公开(公告)号：AU2009268381A1
公开(公告)日：2010-01-14
申请号：AU2009268381
申请日：2009-07-10
Applicant: ACADEMIA SINICA
Inventor： HUNG JUNG-TUNG , LIN YI-LING , JAN JIA-TSRONG , WONG CHI-HUEY , CHENG Y S EDMOND , YU ALICE , CHANG YA-JEN , LIN KUN-HSIEN
Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.
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Patent Agency Ranking
公开(公告)号：GB2461656A
公开(公告)日：2010-01-13
申请号：GB0917142
申请日：2009-07-10
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HUEY , YU ALICE , CHANG YA-JEN , LIN KUN-HSIEN , CHENG Y S EDMOND , JAN JIA-TSRONG , LIN YI-LING , HUNG JUNG-TUNG
IPC: C07H15/18 , A61K31/7034 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P35/00 , A61P43/00
Abstract: The present disclosure relates to synthetic alpha-galaclosyl ceramide (alpha-GalCer) analogs, and their use as immunotherapies, adjuwants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1:: or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.
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公开(公告)号：AU2020227040A1
公开(公告)日：2020-09-17
申请号：AU2020227040
申请日：2020-09-02
Applicant: ACADEMIA SINICA
Inventor： YU ALICE L , LIN KUN-HSIEN , WU TAI-NA , WONG CHI-HUEY
Abstract: HUMAN INKT CELL ACTIVATION USING GLYCOLIPIDS Glycosphingolipids (GS Ls) compositions and methods for iNKT-independent induction of chemokines are disclosed.
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公开(公告)号：AU2015315294B2
公开(公告)日：2020-09-17
申请号：AU2015315294
申请日：2015-09-08
Applicant: ACADEMIA SINICA
Inventor： YU ALICE L , LIN KUN-HSIEN , WU TAI-NA , WONG CHI-HUEY
Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.
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公开(公告)号：CA2756053C
公开(公告)日：2018-10-30
申请号：CA2756053
申请日：2009-07-10
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HUEY , YU ALICE , CHANG YA-JEN , LIN KUN-HSIEN , HUNG JUNG-TUNG
Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (.alpha.- GalCer) analogs, and their use as immunotherapies, adju-vants, and antiviral, antibacterial, and anticancer agents. In one aspect, a method of activating a cy-tokine response in a subject includes administer-ing an effective amount of a compound to a sub-ject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1 :; or a pharmaceutically acceptable salt thereof; forming a complex between the com-pound and the antigen-presenting cell, wherein the formation of the complex results in the activa-tion of a receptor on the lymphocyte; and activat-ing the lymphocyte to produce the cytokine re-sponse.
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公开(公告)号：AU2014317889A1
公开(公告)日：2016-03-17
申请号：AU2014317889
申请日：2014-09-08
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HUEY , YU ALICE L , LIN KUN-HSIEN , WU TAI-NA
IPC: A61K35/14 , A61K31/7012 , A61K31/739
Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.
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