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    PRODUCTION OF SLAT OF PHARMACEUTICALLY ACTIVE MATERIAL
    2.
    发明专利
    PRODUCTION OF SLAT OF PHARMACEUTICALLY ACTIVE MATERIAL 失效

    公开(公告)号：JPH1072400A

    公开(公告)日：1998-03-17

    申请号：JP16085497

    申请日：1997-06-18

    Applicant: BASF AG

    Inventor： BREITENBACH JOERG DR ,  ROSENBERG JOERG DR ,  NEUMANN JOERG DR ,  ZEIDLER JUERGEN DR ,  SIMON DIRK DR ,  DIENER RALPH DR

    IPC: A61K31/19 ,  A61K9/16 ,  A61K31/00 ,  B01J19/00 ,  C07C51/41 ,  C07C57/30 ,  C07C229/26

    Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a salt of a pharmaceutically active material without lowering a quality, especially fluidity by reacting an acid with a base in a molten liquid so that the acid may be reacted with at least stoichiometric amount of the base in an extruder. SOLUTION: The objective salt of a pharmaceutically active material is obtained by reacting (A) a carboxylic acid with (B) a base in a molten liquid so that the acid may be reacted with at least stoichiometric amount of the base in an extruder. The method is preferably used for production of a salt of a derivative of salicylic acid, e.g. acetylasalicylic acid, or an arylcarboxylic acid, e.g. diclofenac, tolmetin or zomepirac. A basic α-aminocarboxylic acid, especially ricin, a base of an alkali(ne earth) metal, etc., are preferable as the component B. The amount of the above base is at least stoichiometric amount, preferably 1-40mol% excess based on the acid.

    4.
    发明专利
    未知

    公开(公告)号：ES2138423T3

    公开(公告)日：2000-01-01

    申请号：ES97113339

    申请日：1997-08-01

    Applicant: BASF AG

    Inventor： WUNSCH JOSEF DR ,  SCHIESSL MICHAEL ,  DIENER RALPH DR

    IPC: C08F4/642 ,  B01J19/20 ,  B01J19/24 ,  C08F4/659 ,  C08F4/6592 ,  C08F12/04 ,  C08F112/00 ,  C08F112/08

    Abstract: A process for the production of an essentially syndiotactic and partially crystalline polymer (I) containing vinyl aromatic monomers is claimed. (I) is prepared form a reaction mixture containing vinyl aromatic compounds (II), metallocene complexes (III) and one or co-catalysts (IV) consisting of strong, neutral Lewis acid or Bronsted acid cations. The components are mixed prior to addition to the reactor. An apparatus is also claimed comprising a reservoir to contain a mixture of (II) and (IV), a reservoir to contain (III) plus means to dose the contents of the 2 reservoirs to a pre-mixer that is connected to the reactor vessel.

    Prepn. of vinyl] polymers of low mol. wt.
    10.
    发明专利
    Prepn. of vinyl] polymers of low mol. wt. 未知

    公开(公告)号：DE4203278A1

    公开(公告)日：1993-08-12

    申请号：DE4203278

    申请日：1992-02-06

    Applicant: BASF AG

    Inventor： KEMPTER FRITZ ERDMANN DR ,  NIESSNER MANFRED DR ,  DIENER RALPH DR ,  THIELE HEINO DR ,  WEISS WOLFRAM DR ,  RENZ HANS DR

    IPC: B01J19/18 ,  C08F2/00

    Abstract: The continuous polymerisation of vinyl monomers by formation of vinyl polymers (I) with a mol. wt. of 1000-20,000 is claimed. The polymerisation is carried out at 110-270 deg. C in a ring slit (slit width 0.5-1.00 mm) that is bounded on the inner side by a rotor. Also claimed is the use of (I) as binding agents for paints, protective coatings, paper coating materials and printing inks. The reaction temp. is 150-270 deg. C and the polymer dispersivity (Mw/Mn) of (I) is less than 3.5. A portion of the volumetric flow is recirculated through the ring slit such that the recycle ratio of recirculated volumetric flow to throughput is 2-35. The rotor promotes reacton by thorough mixing and has a tangential avelocity of 0.5-2 m/s. The reaction is carried out in 0-40% of a solvent (w.r.t. monomer). The mixt. of monomers comprises 60-100 wt.% (meth)acrylic acid esters. Polymerisation initiator is added in a molar ratio of 0.0005:1 to 0.1:1 (w.r.t. monomer).

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