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    PRODUCTION OF SOLID MEDICINE MOLDING
    2.
    发明专利
    PRODUCTION OF SOLID MEDICINE MOLDING 失效

    公开(公告)号：JPH1057450A

    公开(公告)日：1998-03-03

    申请号：JP19539097

    申请日：1997-07-22

    Applicant: BASF AG

    Inventor： ZETTLER HANS DIETER ,  SCHIESL MICHAEL ,  BREITENBACH JOERG DR ,  ROSENBERG JOERG DR

    IPC: A61J3/10 ,  A61J3/06 ,  A61K9/20 ,  B30B11/22

    Abstract: PROBLEM TO BE SOLVED: To embody an easy and cost effective process for producing solid medicine moldings particularly to specified shapes by dividing extrudate to molded goods in a first stage and rounding these molded goods in a plastic state in a second stage. SOLUTION: A mixture composed of a polymer/active component for production of tablets is produced by a simultaneously rotating two-screw extrusion molding machine. The plastic compsn. is extruded and is received by a circulating belt conveyor. A sensor operates a cutting device when the sensor checks the start point of the extrudate. The columnar molded goods 13 are temporarily stored in a collector 18 and are, in succession, supplied through a drilling slide gate 20 to a rounding tool 21. An arc-shaped driver 22 supports and moves the molded goods 13 during this time and rotates the molded goods round the longitudinal axis. The flat ends of the molded goods pass the heated rounding tool during this time. Two metallic jaws are moved in the same direction as the direction of the longitudinal axis of the molded goods 13 and the center of the dents of the segment type of a spherical shape is arranged on the longitudinal axis.

    4.
    发明专利
    未知

    公开(公告)号：DE19539362A1

    公开(公告)日：1997-04-24

    申请号：DE19539362

    申请日：1995-10-23

    Applicant: BASF AG

    Inventor： BREITENBACH JOERG DR ,  HAERTL AXEL PAUL DR ,  MAIER WERNER ,  ROSENBERG JOERG DR ,  SCHIESL MICHAEL ,  ZETTLER HANS DIETER

    IPC: A61K9/14 ,  A61K9/16 ,  A61K9/24

    Abstract: The invention concerns a method of producing medicaments in solid form by mixing and melting at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives in the absence of a solvent to form a plastic mixture, and shaping this mixture to form the desired medicament, the mixing, melting and shaping steps being carried out continuously and separately. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.

    5.
    发明专利
    未知

    公开(公告)号：DE19539363A1

    公开(公告)日：1997-04-24

    申请号：DE19539363

    申请日：1995-10-23

    Applicant: BASF AG

    Inventor： BREITENBACH JOERG DR ,  HAERTL AXEL PAUL DR ,  ROSENBERG JOERG DR ,  SCHIESL MICHAEL ,  ZETTLER HANS DIETER

    IPC: A61K9/20 ,  A61K9/22 ,  A61K9/16

    Abstract: The invention concerns a method of producing medicaments in solid form by mixing and melting at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives in the absence of a solvent to form a plastic mixture, and shaping the mixture to form the desired medicament, mixing and melting being carried out in separate stages. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.

    6.
    发明专利
    未知

    公开(公告)号：DE19539360A1

    公开(公告)日：1997-04-24

    申请号：DE19539360

    申请日：1995-10-23

    Applicant: BASF AG

    Inventor： BREITENBACH JOERG DR ,  HAERTL AXEL PAUL DR ,  ROSENBERG JOERG DR ,  SCHIESL MICHAEL ,  ZETTLER HANS DIETER

    IPC: A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K31/19

    Abstract: The invention concerns a method of producing medicaments in solid form by mixing at least one pharmacologically acceptable polymer binder, at least one pharmaceutical active substance and optionally conventional pharmaceutical additives, extruding the mixture and shaping the medicament, a pre-mixture being prepared from the components and fed into the extruder. The method according to the invention enables high-quality medicaments to be produced in a simple and careful manner.

    7.
    发明专利
    未知

    公开(公告)号：DE19631365A1

    公开(公告)日：1998-02-05

    申请号：DE19631365

    申请日：1996-08-02

    Applicant: BASF AG

    Inventor： WUENSCH JOSEF DR ,  SCHIESL MICHAEL ,  DIENER RALPH DR

    IPC: C08F4/642 ,  B01J19/20 ,  B01J19/24 ,  C08F4/659 ,  C08F4/6592 ,  C08F12/04 ,  C08F112/00 ,  C08F112/08 ,  C08F12/00

    Abstract: A process for the production of an essentially syndiotactic and partially crystalline polymer (I) containing vinyl aromatic monomers is claimed. (I) is prepared form a reaction mixture containing vinyl aromatic compounds (II), metallocene complexes (III) and one or co-catalysts (IV) consisting of strong, neutral Lewis acid or Bronsted acid cations. The components are mixed prior to addition to the reactor. An apparatus is also claimed comprising a reservoir to contain a mixture of (II) and (IV), a reservoir to contain (III) plus means to dose the contents of the 2 reservoirs to a pre-mixer that is connected to the reactor vessel.

    9.
    发明专利
    未知

    公开(公告)号：DE19629753A1

    公开(公告)日：1998-01-29

    申请号：DE19629753

    申请日：1996-07-23

    Applicant: BASF AG

    Inventor： ZETTLER HANS DIETER ,  SCHIESL MICHAEL ,  BREITENBACH JOERG DR ,  ROSENBERG JOERG DR

    IPC: A61J3/10 ,  A61J3/06 ,  A61K9/20 ,  B30B11/22

    Abstract: Production of solid medicament comprises mixing and melting at least one polymeric binder, at least one pharmaceutical active agent (A) and optionally conventional additives, in the absence of solvents, to give a plastic mixture and shaping the mixture by extrusion. The shaping is carried out in two stages: (i) dividing the extrudate into shaped articles; and (ii) rounding the articles while in a plastic state.

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