公开(公告)号：JPH1067686A

公开(公告)日：1998-03-10

申请号：JP20442197

申请日：1997-07-30

Applicant: BASF AG

Inventor： LUESSEN HENRIK L ,  BORCHARD GERRIT ,  BOER ALBERTUS G DE ,  JUNGINGER HANS E ,  KOLTER KARL ,  SCHEHLMANN VOLKER ,  SANNER AXEL

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/78 ,  A61K47/30 ,  A61K47/32

Abstract: PROBLEM TO BE SOLVED: To prepare pharmaceutical preparation having no danger of a cytolytic or other toxic side effect and capable of eliminating an technical defect of use of a high viscosity material, etc., and improving permeability through an epithelial cell by including a (meth)acrylic acid-maleic acid copolymer. SOLUTION: This pharmaceutical preparation is the one for improving permeability through an epithelial cell and includes a (meth)acrylic acid-maleic acid copolymer e.g. the one composed of (A) 10-90mol% (meth)acrylic acid or its salt or anhydride, (B) 90-10mol% maleic acid or its salt or anhydride and (C) 0-40mol% monomer without components A and B [e.g. vinylsulfonic acid, a (meth)acrylic ester of a 2-6C hydroxyalkyl or a (meth)acrylic acid ester of 1-40C alkyl] and having 5,000-500,000, especially 10,000-300,000 weight average molecular weight}. The preparation is administered in a shape of a tablet, a granule, a suppository, an ointment, a solution, etc., by an oral, hypoglottis, oral cavity, pulmonary artery or pernasal administration, or an administration through ocular-mucous membrance.

公开(公告)号：JP2006316266A

公开(公告)日：2006-11-24

申请号：JP2006114546

申请日：2006-04-18

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： KOLTER KARL ,  ASCHERL HERMANN ,  FUSSNEGGER BERNHARD

IPC: C08L39/04 ,  A61K9/20 ,  A61K47/32 ,  C08J3/12

CPC classification number: A61K47/32 ,  A61K9/2027 ,  C08F226/06 ,  C08F226/10

Abstract: PROBLEM TO BE SOLVED: To provide a powder shape finely crushed binder useful on the production of tablets, and to provide a method for producing the same. SOLUTION: This powder shape finely crushed binder comprises a vinyl lactam polymer, having an average particle size of ≤35 μm and an apparent density of ≤0.2 g/ml. The method for producing the binder comprises spraying a vinyl lactam polymer aqueous solution having a solid content of 1 to 35 wt.% with a single liquid nozzle under a pressure of ≥8 MPa or with a double liquid nozzle under a pressure of ≥0.2 MPa, and then drying the sprayed product with a hot gas flow. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 待解决的问题：提供可用于制备片剂的粉末形状的细粉碎粘合剂，并提供其制备方法。 解决方案：该粉末形状的细粉碎粘合剂包括平均粒径≤35μm，表观密度≤0.2g/ ml的乙烯基内酰胺聚合物。 制造粘合剂的方法包括在≥8MPa的压力下用单液体喷嘴或在≥0.2MPa的压力下用双液体喷嘴喷雾固体含量为1〜35重量％的乙烯基内酰胺聚合物水溶液 ，然后用热气流干燥喷雾产物。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2002179741A

公开(公告)日：2002-06-26

申请号：JP2001309183

申请日：2001-10-04

Applicant: BASF AG

Inventor： ANGEL MAXIMILIAN ,  SANNER AXEL ,  KOLTER KARL

IPC: A61K47/32 ,  A61K9/20 ,  A61K9/28 ,  A61K9/32 ,  C08F216/06 ,  C08F218/04 ,  C08F220/28 ,  C08F261/04

Abstract: PROBLEM TO BE SOLVED: To obtain a water-soluble or water-dispersible polymer having overcome conventionally unsolved weak points as a coating agent, a binder and/or film-forming excipient in pharmaceutical dosage form, especially for instantly deliverable tablet. SOLUTION: This water-soluble or water-dispersible copolymer is obtained by free-radical polymerization in the presence of a) 80 to 20 wt.% of hydroxy-C1 to C6 alkyl (meth)acrylate and optionally one or more compounds expressed by formula (A) or formula (B) (where R1=H, C1 to C6 alkyl; R2=H, CH3; R3=C1 to C14 alkyl) or mixture thereof, b) 20 to 80 wt.% of polyvinylalcohol(PVA) and c) optionally 0 to 20 wt.% of other polymerizable compound (C). The method of producing the copolymer and the use of the copolymer as a coating agent, a binder and/or film-forming excipient in pharmaceutical dosage form are also provided.

公开(公告)号：JP2000143544A

公开(公告)日：2000-05-23

申请号：JP31979199

申请日：1999-11-10

Applicant: BASF AG

Inventor： ZIRNSTEIN MICHAEL ,  RUCHATZ FOLKER ,  KOLTER KARL ,  OPPENLAENDER KNUT

IPC: A23L29/10 ,  A23L33/15 ,  A61K8/00 ,  A61K8/30 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/39 ,  A61K8/42 ,  A61K8/45 ,  A61K8/86 ,  A61K47/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/34 ,  A61Q19/00 ,  C07C69/66 ,  C07C69/675 ,  C07C69/732 ,  C07C259/06 ,  C08G65/00 ,  C08G65/332 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound capable of manifesting good solubilizing actions on a hydrophobic drug without highly releasing histamine undesirable in parenteral application and useful as a solubilizing agent for medicines, cosmetic preparations and food preparations. SOLUTION: This hydroxylated carboxylic acid ester or amide represented by the formula [R1 is a 1-22C acyl or the like; R2 is a 1-16C alkyl or a 2-12C alkenyl; R3 is a 1-16C alkylene or the like; R4 is a 1-12C alkyl, a 2-12C alkenyl or the like; A is N(R5)-R6 (R5 is H, a 1-12C alkyl or the like; R6 is CH2-CH2); B is CH2-CH2-O, CH2-CH2-CH2-O or the like; (x) is 1-6; (y) is 0 or 1; (z) is 8-18], e.g. methyl 12-hydroxystearate polyethylene glycol (500) monoester is used as a solubilizing agent. The compound represented by the formula is capable of manifesting a good solubilizing power for an active ingredient of medicines and cosmetics without any adverse effects.

公开(公告)号：WO2006002808A3

公开(公告)日：2006-09-14

申请号：PCT/EP2005006718

申请日：2005-06-22

Applicant: BASF AG ,  KOLTER KARL ,  ANGEL MAXIMILIAN ,  HABICH ANDREAS

Inventor： KOLTER KARL ,  ANGEL MAXIMILIAN ,  HABICH ANDREAS

IPC: A61K9/28 ,  A61K9/16

CPC classification number: A61K9/2853 ,  A61K9/284

Abstract: The invention relates to a rapidly dispersible, fine-grained, separation-resistant film coating agent for coating pharmaceutical dosage forms, consisting of a) 40 - 90 wt % of a polyvinyl alcohol-polyether graft copolymer (component A), b) 1 - 20 wt. % of a polyvinyl pyrrolidone or a vinyl pyrrolidone-vinyl acetate copolymer with a K-value of between 10 and 100 (component B), c) 10 - 60 wt. % of an organic or inorganic pigment with an average particle size that is less than 8 µm (component C), d) 0.5 - 15 wt. % of a surfactant with an HLB value that is greater than 10 (component D) and e) 0 - 30 wt % of additional conventional coating constituents (component E). In said agent, the particles of component C are embedded in a coherent polymer matrix and the quantity of components A to E totals 100 wt. %.

Abstract translation: Schnelldispergierbares，细碎的不偏析趋于粉末包衣组合物用于涂覆药物剂型，包括一个）40 - 90重量聚乙烯醇 - 聚醚接枝共聚物的％（组分A），B）1 - 20重量聚乙烯吡咯烷酮的％或 具有10至100（B成分）c）中的K值从10至60重量％0.5具有8微米以下（C成分的平均粒径的有机或无机颜料情况）d）由乙烯基吡咯烷酮 - 乙酸乙烯酯共聚物，以15％的 .-具有HLB值大于10（D成分），和e）0-30重量其它常规包衣成分（分量e的百分比），其中组分C的颗粒被嵌入在一个连贯聚合物基质中的表面活性剂的％，其中 组分A至E的量为100添加重量％。

公开(公告)号：WO2007028758A3

公开(公告)日：2007-05-10

申请号：PCT/EP2006065865

申请日：2006-08-31

Applicant: BASF AG ,  KOLTER KARL

Inventor： KOLTER KARL

IPC: A61K9/48

CPC classification number: A61K9/4816 ,  B29C47/0021 ,  B29C47/786 ,  B29C47/822 ,  B29C47/8845 ,  C11D17/0039

Abstract: Disclosed is a method for producing gelatin-free soft capsule envelopes based on polyvinyl alcohol-polyether graft polymers as enveloping polymers. Said method is characterized in that an aqueous solution containing at least 45 percent by weight of a polymer component which comprises a polyvinyl alcohol-polyether graft polymer or a mixture of polyvinyl alcohol-polyether graft polymers and polyvinyl alcohol is heated, the percentage being in relation to the total weight of the solution, the solution is extruded at a minimum temperature of 70 °C, and the obtained film is solidified by cooling.

Abstract translation: 一种用于基于无明胶软胶囊壳的制造方法，其特征聚乙烯醇 - 聚醚接枝聚合物作为壳聚合物，加入含有至少45重量％的水溶液中，基于溶液的总重量的聚合物组分，其中所述聚合物组分由聚乙烯醇的 聚醚接枝聚合物或聚乙烯醇 - 聚醚接枝共聚物和聚乙烯醇的混合物加热，将溶液在至少70℃的温度下挤出并凝固所造成的冷却薄膜。

公开(公告)号：WO9805360A3

公开(公告)日：1998-05-07

申请号：PCT/EP9703899

申请日：1997-07-21

Applicant: BASF AG ,  KOLTER KARL ,  SUBKOWSKI THOMAS ,  RADITSCH MARTIN ,  SCHEHLMANN VOLKER

Inventor： KOLTER KARL ,  SUBKOWSKI THOMAS ,  RADITSCH MARTIN ,  SCHEHLMANN VOLKER

IPC: A61K9/02 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/78 ,  A61K33/24 ,  A61K45/06 ,  A61K47/32

CPC classification number: A61K47/32 ,  A61K9/2027 ,  A61K9/2846 ,  A61K31/78 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

Abstract: (Meth)acrylic acid copolymers used to increase the permeability of mucous membranes contain as comonomers (meth)acrylic acid esters and/or other radically polymerisable monomers, the molar ratio between (meth)acrylic acid and comonomer varying between 99:1 and 1:99.

公开(公告)号：WO2007071581A3

公开(公告)日：2008-01-10

申请号：PCT/EP2006069515

申请日：2006-12-11

Applicant: BASF AG ,  KOLTER KARL ,  WICHTNER MARCUS ,  SCHOENHERR MICHAEL ,  MITTWOLLEN JAN-PETER

Inventor： KOLTER KARL ,  WICHTNER MARCUS ,  SCHOENHERR MICHAEL ,  MITTWOLLEN JAN-PETER

IPC: A61K9/00 ,  A61K9/20

CPC classification number: A61K9/0056 ,  A61K9/2018

Abstract: The invention relates to a pharmaceutical formulation in the form of agglomerates containing a) 60 - 97 % by weight of sugar or sugar alcohols, b) 1 - 25 % by weight of cross-linked polyvinylpyrrolidone, c) 1 - 15 % by weight of water-insoluble, film-forming polymers, d) 0 - 15 % by weight of water-soluble polymers, and e) 0 - 15 % by weight of other pharmaceutically suitable adjuvants, the sum of components a) to e) adding up to 100 % by weight.

Abstract translation: 在含有糖或糖醇的）60-97重量％的聚集体形式的药物制剂，b）中1 - 25重量％的交联聚乙烯吡咯烷酮，C）1 - 15重量％的水不溶性，成膜聚合物d）0 - 15 重量的水溶性聚合物的.-％，和e）0 - 15重量％的其它药学上常用的赋形剂，其中组分的总和a）至e）为100重量％（重量）。

公开(公告)号：WO9623489A3

公开(公告)日：1996-10-03

申请号：PCT/EP9600381

申请日：1996-02-02

Applicant: BASF AG ,  SCHMUTZLER WOLFGANG ,  KOLTER KARL

Inventor： SCHMUTZLER WOLFGANG ,  KOLTER KARL

IPC: A61K31/015 ,  A61K31/047 ,  A61K31/12 ,  A61K31/122 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61K31/07

CPC classification number: A61K31/122 ,  A61K31/015 ,  A61K31/047 ,  A61K31/12 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/864 ,  Y10S514/865 ,  Y10S514/87 ,  Y10S514/871 ,  Y10S514/886 ,  Y10S514/887

Abstract: Carotinoids are used for preparing medicaments for treating inflammatory diseases that are not caused by exposure to light or by micro-organism infection.

公开(公告)号：CA2474934C

公开(公告)日：2010-10-19

申请号：CA2474934

申请日：2003-02-04

Applicant: BASF AG

Inventor： KOLTER KARL ,  ANGEL MAXIMILIAN

IPC: A61K9/28

Abstract: The invention relates to a rapidly soluble film covering agent for covering solid substrates, comprising a) 10- 90 wt.- % of a polyvinylalcohol-polyether graft copolymer (component A), b) 5- 80 wt.- % of at least one additional component containing at least one functional group selected from the group containing hydroxy, amide and ester functions (component B), and c) 0- 70 wt.-% of additional standard coating components (components C).