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    PHARMACEUTICAL PREPARATION IMPROVING PERMEABILITY THROUGH MUCOSA
    1.
    发明专利
    PHARMACEUTICAL PREPARATION IMPROVING PERMEABILITY THROUGH MUCOSA 失效

    公开(公告)号：JPH1067686A

    公开(公告)日：1998-03-10

    申请号：JP20442197

    申请日：1997-07-30

    Applicant: BASF AG

    Inventor： LUESSEN HENRIK L ,  BORCHARD GERRIT ,  BOER ALBERTUS G DE ,  JUNGINGER HANS E ,  KOLTER KARL ,  SCHEHLMANN VOLKER ,  SANNER AXEL

    IPC: A61K9/00 ,  A61K9/20 ,  A61K31/78 ,  A61K47/30 ,  A61K47/32

    Abstract: PROBLEM TO BE SOLVED: To prepare pharmaceutical preparation having no danger of a cytolytic or other toxic side effect and capable of eliminating an technical defect of use of a high viscosity material, etc., and improving permeability through an epithelial cell by including a (meth)acrylic acid-maleic acid copolymer. SOLUTION: This pharmaceutical preparation is the one for improving permeability through an epithelial cell and includes a (meth)acrylic acid-maleic acid copolymer e.g. the one composed of (A) 10-90mol% (meth)acrylic acid or its salt or anhydride, (B) 90-10mol% maleic acid or its salt or anhydride and (C) 0-40mol% monomer without components A and B [e.g. vinylsulfonic acid, a (meth)acrylic ester of a 2-6C hydroxyalkyl or a (meth)acrylic acid ester of 1-40C alkyl] and having 5,000-500,000, especially 10,000-300,000 weight average molecular weight}. The preparation is administered in a shape of a tablet, a granule, a suppository, an ointment, a solution, etc., by an oral, hypoglottis, oral cavity, pulmonary artery or pernasal administration, or an administration through ocular-mucous membrance.

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