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公开(公告)号：WO0110847A8
公开(公告)日：2001-12-06
申请号：PCT/EP0007440
申请日：2000-08-01
Applicant: BASF AG , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D213/73 , C07D491/04
CPC classification number: C07D401/06 , C07D223/20 , C07D243/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14
Abstract: The invention relates to novel compounds of formula (I) which bind to integrin receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that can be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL RL )b-, -CRL =CRL -, ethylene or =CRL -, wherein a is 0 or 1; b is 0, 1 or 2; XL represents CRL RL , NRL , oxygen or sulfur and G is a structural element of formula IG, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG . The invention also relates to the production of said compounds and to their use as medicaments.
Abstract translation: 本发明涉及式（I）的化合物BGL（I）其中G和L具有以下含义：L式IL -UT（IL），其中T是基团COOH或水解性与COOH和-U-自由基的结构元件 - （XL ）α-（CRL <1> RL <2>）b -CRL <1> CRL <1> CRL <2> - ，亚乙炔基或= CRL <1> - 表示，其中a是0或1，b 0,1或2 XL CRL <3> RL <4> NRL <5>，氧或硫，G是式LG（IG）的结构元件的结构元件G能够以两个方向和XG进行的，其中，所述安装是氮或CRG < 1与整联蛋白受体结合，它们的产生和它们作为药物的用途。
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公开(公告)号：WO0110847A3
公开(公告)日：2001-11-01
申请号：PCT/EP0007440
申请日：2000-08-01
Applicant: BASF AG , KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D213/73 , C07D491/04
CPC classification number: C07D401/06 , C07D223/20 , C07D243/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14
Abstract: The invention relates to novel compounds of formula (I) which bind to integrin receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that can be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL RL )b-, -CRL =CRL -, ethylene or =CRL -, wherein a is 0 or 1; b is 0, 1 or 2; XL represents CRL RL , NRL , oxygen or sulfur and G is a structural element of formula IG, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG . The invention also relates to the production of said compounds and to their use as medicaments.
Abstract translation: 本发明涉及式（I）的化合物BGL（I）其中G和L具有以下含义：L式IL -UT（IL），其中T是基团COOH或水解性与COOH和-U-自由基的结构元件 - （XL ）α-（CRL <1> RL <2>）b -CRL <1> CRL <1> CRL <2> - ，亚乙炔基或= CRL <1> - 表示，其中a是0或1，b 0,1或2 XL CRL <3> RL <4> NRL <5>，氧或硫，G是式LG（IG）的结构元件的结构元件G能够以两个方向和XG进行的，其中，所述安装是氮或CRG < 1>结合至整联蛋白受体，它们的制备和它们作为药物的用途。
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公开(公告)号：CA2379977A1
公开(公告)日：2001-02-15
申请号：CA2379977
申请日：2000-08-01
Applicant: BASF AG
Inventor： HORNBERGER WILFRIED , LANGE UDO , GENESTE HERVE , KLING ANDREAS , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , GRAEF CLAUDIA ISABELLA , LAUTERBACH ARNULF , LAUX VOLKER , SADOWSKI JENS
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D221/00 , C07D223/00 , C07D233/00 , C07D333/00 , C07D491/04 , C07D213/73
Abstract: The invention relates to novel compounds of formula (I) which bind to integr in receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that c an be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL1RL2)b-, -CRL1=CRL2 -, ethylene or =CRL1-, wherein a is 0 or 1; b is 0, 1 or 2; XL represents CRL3RL4, NRL5, oxygen or sulfur and G is a structural element of formula IG, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG1. The invention also relates to the production of said compounds and to their use as medicaments.
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公开(公告)号：NO20025759A
公开(公告)日：2003-01-14
申请号：NO20025759
申请日：2002-11-29
Applicant: BASF AG
Inventor： ROSENBERG JOERG , BREITENBACH JOERG , HERR DIETER , LAUX VOLKER , HEGER ROBERT
IPC: A61K47/12 , A61K9/16 , A61K31/726 , A61K31/727 , A61K47/14 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/38 , A61K47/44 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/06 , A61P9/10 , A61P11/00 , A61P13/12 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/06
CPC classification number: A61K9/1635 , A61K9/1617 , A61K9/1652 , A61K31/726 , A61K31/727
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公开(公告)号：BG106395A
公开(公告)日：2002-12-29
申请号：BG10639502
申请日：2002-02-06
Applicant: BASF AG
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA I , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D243/00
Abstract: The invention relates to novel compounds to integrin receptors, to the production thereof and their use as medicaments. 14 claims
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Patent Agency Ranking
公开(公告)号：TR200200357T2
公开(公告)日：2002-09-23
申请号：TR200200357
申请日：2000-08-01
Applicant: BASF AG
Inventor： KLING ANDREAS , GENESTE HERV , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBSKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14
Abstract: The invention relates to novel compounds which bind to integrin receptors, and to the preparation thereof and the use thereof as drugs.
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公开(公告)号：NO20020644A
公开(公告)日：2002-03-18
申请号：NO20020644
申请日：2002-02-08
Applicant: BASF AG
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D
CPC classification number: C07D401/06 , C07D223/20 , C07D243/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14
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公开(公告)号：DE19936780A1
公开(公告)日：2001-02-15
申请号：DE19936780
申请日：1999-08-09
Applicant: BASF AG
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH ARNULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D487/04
Abstract: The invention relates to novel compounds binding to integrin receptors, to the production thereof and to their use as medicaments.
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公开(公告)号：CZ2002439A3
公开(公告)日：2002-11-13
申请号：CZ2002439
申请日：2000-08-01
Applicant: BASF AG
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH AMULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D243/10 , C07D487/04
Abstract: The invention relates to novel compounds which bind to integrin receptors, and to the preparation thereof and the use thereof as drugs.
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公开(公告)号：CZ20020439A3
公开(公告)日：2002-11-13
申请号：CZ20020439
申请日：2000-08-01
Applicant: BASF AG
Inventor： KLING ANDREAS , GENESTE HERVE , LANGE UDO , LAUTERBACH AMULF , GRAEF CLAUDIA ISABELLA , SUBKOWSKI THOMAS , HOLZENKAMP UTA , MACK HELMUT , SADOWSKI JENS , HORNBERGER WILFRIED , LAUX VOLKER
IPC: A61K31/4402 , A61K31/55 , A61K31/5513 , A61P3/14 , A61P5/18 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/08 , A61P19/10 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D213/74 , C07D223/20 , C07D243/38 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14 , C07D243/10 , C07D487/04
CPC classification number: C07D401/06 , C07D223/20 , C07D243/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14
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