公开(公告)号：DE19631084A1

公开(公告)日：1998-02-05

申请号：DE19631084

申请日：1996-08-01

Applicant: BASF AG

Inventor： KOLTER KARL DR ,  SUBKOWSKI THOMAS DR ,  RADITSCH MARTIN DR ,  SCHEHLMANN VOLKER DR

IPC: A61K9/02 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/78 ,  A61K33/24 ,  A61K45/06 ,  A61K47/32 ,  A61K31/545 ,  A61K31/785 ,  A61K31/765 ,  A61K31/52 ,  A61K31/135

Abstract: (Meth)acrylic acid copolymers used to increase the permeability of mucous membranes contain as comonomers (meth)acrylic acid esters and/or other radically polymerisable monomers, the molar ratio between (meth)acrylic acid and comonomer varying between 99:1 and 1:99.

公开(公告)号：DE19605126A1

公开(公告)日：1997-08-14

申请号：DE19605126

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOLLSCHWEILER CLAUS DR ,  SCHMIDT MARTIN DR ,  RADITSCH MARTIN DR ,  RUEBSAMEN KLAUS DR ,  HOEFFKEN HANS WOLFGANG DR ,  SCHWEDEN JUERGEN DR ,  FRIEDRICH THOMAS DR

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C07K14/745 ,  A61K38/57 ,  C07H21/04 ,  A61K38/36

Abstract: The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.