公开(公告)号：ES2054650T3

公开(公告)日：1994-08-16

申请号：ES87117946

申请日：1987-12-04

Applicant: BASF AG

Inventor： SEITZ WERNER DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  BALDINGER VERENA DR ,  RUEBSAMEN KLAUS DR ,  GRIES JOSEF DR

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61P1/04 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/37 ,  C07C255/42 ,  C07C255/53 ,  C07C255/58 ,  C07D317/50 ,  C07D317/60 ,  C07D319/08 ,  C07D319/18 ,  C07D321/00

Abstract: Basic-substituted phenylacetonitriles of the formula I … … in which… R to R and n have the meaning given in the description, are suitable for combating diseases.

公开(公告)号：DE3865480D1

公开(公告)日：1991-11-21

申请号：DE3865480

申请日：1988-03-18

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  RUEBSAMEN KLAUS DR

IPC: A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/50 ,  A61K31/505 ,  A61P1/04 ,  C07D307/86 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06

Abstract: 5-Substd.-4,7-dihydroxy -6-aminoalkoxy-benzofuran derivs. of formula (I) are new. In (I), R1, R2 = H, 1-4C alkyl or phenyl-1-4C alkyl; R3, R4 = H or 1-4C alkyl; or R3 + R4 = 3-5 membered chain opt. interrupted by O or NR1, X = (a)-CO-CH=CH-, (b)-COCH2CH2- or (c)-CH(OH)CH2CH2-; n = 2 or 3; Het = aromatic 5- or 6-membered ring contg. an N, O or S heteroatom and opt. an additional N atom, opt. substd. by 1-4C alkyl, F, Cl, Br, NH2 or NR1R2.

公开(公告)号：DE3710469A1

公开(公告)日：1988-10-20

申请号：DE3710469

申请日：1987-03-30

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  RUEBSAMEN KLAUS DR

IPC: A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/50 ,  A61K31/505 ,  A61P1/04 ,  C07D307/86 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  A61K31/34 ,  A61K31/395 ,  C07D409/10 ,  C07D521/00

公开(公告)号：ES2041719T3

公开(公告)日：1995-04-01

申请号：ES88104306

申请日：1988-03-18

Applicant: BASF AG

Inventor： SCHLECKER RAINER DR ,  RUEBSAMEN KLAUS DR

IPC: A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/50 ,  A61K31/505 ,  A61P1/04 ,  C07D307/86 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06

公开(公告)号：AT78702T

公开(公告)日：1992-08-15

申请号：AT89101849

申请日：1989-02-03

Applicant: BASF AG

Inventor： ESCHENFELDER VOLKER DR ,  SCHMIED BERNHARD DR ,  RUEBSAMEN KLAUS DR

IPC: A61K38/16 ,  A61K38/49 ,  A61K38/54 ,  A61K38/58 ,  A61K45/06 ,  A61K37/54 ,  A61K37/547

公开(公告)号：DE3917232A1

公开(公告)日：1990-11-29

申请号：DE3917232

申请日：1989-05-26

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  RUEBSAMEN KLAUS DR ,  TRAUT MARTIN DR

IPC: C07D215/42

Abstract: 4-aminoquinoline derivs. of formula (I) and their salts are new, R1 = H, 1-4C alkyl, 1-4C hydroxyalkyl or (1-4C) alkoxy (1-4C)alkyl, R2 = 1-6C alkyl, R3 = naphthyl or a phenyl gp. of formula R13, R7 = H, 1-3C alkyl, 1-3C alkoxy, halogen, 1-3C alkylthio, CF3, NO2, or 2-4C alkoxycarbonyl, R8 = H, 1-3C alkyl, 1-3C alkoxy, or halogen, n = 1 or 2, R4 = H, 1-3C alkyl or CH2R3, R5 = H, 1-6C alkyl, 1-6C alkoxy, OPh phenyl (1-3C) alkoxy, CF3 or halogen, R6 = H, 1-3C alkyl, 1-3C alkoxy or halogen. USE - (I) are K+/H+ ATPase inhibitors and gastric acid secretion inhibitors useful for treating peptic ulcers, gastritis, oesophagal reflux, Zollinger-Ellison syndrome etc.

公开(公告)号：DE3762970D1

公开(公告)日：1990-07-05

申请号：DE3762970

申请日：1987-01-03

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  SCHMIED BERNHARD DR ,  KROPP RUDOLF ,  BALDINGER VERENA DR ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER PROF DR ,  RUEBSAMEN KLAUS DR ,  TRAUT MARTIN DR

IPC: C07D237/00 ,  A61K31/50 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D403/04 ,  C07D403/10

公开(公告)号：DE19605126A1

公开(公告)日：1997-08-14

申请号：DE19605126

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOLLSCHWEILER CLAUS DR ,  SCHMIDT MARTIN DR ,  RADITSCH MARTIN DR ,  RUEBSAMEN KLAUS DR ,  HOEFFKEN HANS WOLFGANG DR ,  SCHWEDEN JUERGEN DR ,  FRIEDRICH THOMAS DR

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C07K14/745 ,  A61K38/57 ,  C07H21/04 ,  A61K38/36

Abstract: The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：AT110365T

公开(公告)日：1994-09-15

申请号：AT90104777

申请日：1990-03-14

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  RUEBSAMEN KLAUS DR ,  TRAUT MARTIN DR

IPC: A61K31/47 ,  A61K31/475 ,  A61P1/00 ,  A61P1/04 ,  A61P29/00 ,  C07D215/42

公开(公告)号：ES2043903T3

公开(公告)日：1994-01-01

申请号：ES89101849

申请日：1989-02-03

Applicant: BASF AG

Inventor： ESCHENFELDER VOLKER DR ,  SCHMIED BERNHARD DR ,  RUEBSAMEN KLAUS DR

IPC: A61K38/16 ,  A61K38/49 ,  A61K38/54 ,  A61K38/58 ,  A61K45/06 ,  A61K37/54 ,  A61K37/547

Abstract: The mixture is suitable for controlling thrombotic vascular disorders.