公开(公告)号：DE4408690A1

公开(公告)日：1995-09-21

申请号：DE4408690

申请日：1994-03-15

Applicant: BASF AG

Inventor： KROEGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR

IPC: C12N15/09 ,  C12N15/65 ,  C12N15/79 ,  C12Q1/02 ,  C12Q1/66 ,  C12Q1/68 ,  C12Q1/6897

公开(公告)号：DE4134814A1

公开(公告)日：1993-04-29

申请号：DE4134814

申请日：1991-10-22

Applicant: BASF AG

Inventor： FRIEDRICH THOMAS DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR ,  KUENAST CHRISTOPH DR

IPC: A61K35/64 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07K14/435 ,  C07K14/81 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/19

Abstract: Described is a new thrombin-inhibiting protein isolated from ticks, with a molecular weight of about 8000 Daltons and the N-terminus Leu-Asn-Val-Leu-Cys-Asn-Asn-Pro-His-Thr-Ala-Asp-Cys-Asn-Asn-Asp-Ala-Gl n-Val-Asp. The protein is suitable for use in the treatment of illnesses.

公开(公告)号：CZ287396A3

公开(公告)日：1997-04-16

申请号：CZ287396

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST DR ,  VOGELBACHER UWE JOSEF DR ,  RHEINHEIMER JOACHIM DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  KROGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR ,  WERNER VOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I

公开(公告)号：DE4411225A1

公开(公告)日：1995-10-05

申请号：DE4411225

申请日：1994-03-31

Applicant: BASF AG

Inventor： BAUMANN ERNST DR ,  VOGELBACHER UWE JOSEF DR ,  RHEINHEIMER JOACHM DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  KROEGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention concerns the use of carboxylic acid derivatives of formula I (I) in which R means a formyl group, a CO2H group or a residue which can be hydrolysed to form COOH; X means nitrogen or CR , wherein R means hydrogen or, together with R , forms a 3- to 4-member alkylene or alkenylene chain in each of which a methyl group can be replaced by oxygen; Y means sulphur or oxygen or a single bond; Z means sulphur or oxygen; and the other substituents have the meanings given in the description. These derivatives can be used for preparing medicaments.

公开(公告)号：DE19605126A1

公开(公告)日：1997-08-14

申请号：DE19605126

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOLLSCHWEILER CLAUS DR ,  SCHMIDT MARTIN DR ,  RADITSCH MARTIN DR ,  RUEBSAMEN KLAUS DR ,  HOEFFKEN HANS WOLFGANG DR ,  SCHWEDEN JUERGEN DR ,  FRIEDRICH THOMAS DR

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C07K14/745 ,  A61K38/57 ,  C07H21/04 ,  A61K38/36

Abstract: The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：CZ9602873A3

公开(公告)日：1997-04-16

申请号：CZ287396

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST DR ,  VOGELBACHER UWE JOSEF DR ,  RHEINHEIMER JOACHIM DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  KROGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR ,  WERNER VOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/26 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/00

CPC classification number: A61K31/505 ,  A61K31/506 ,  A61K31/53

公开(公告)号：CZ290684B6

公开(公告)日：2002-09-11

申请号：CZ287396

申请日：1995-03-23

Applicant: BASF AG

Inventor： BAUMANN ERNST DR ,  VOGELBACHER UWE JOSEF DR ,  RHEINHEIMER JOACHIM DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  KROGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR ,  WERNER VOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to the use of carboxylic acid derivatives of the general formula I for preparing medicament i.e. endothelin receptor antagonists. The medicament can be used for treating hypertension, renal insufficiency, and restenosis after angioplasty.

公开(公告)号：DE4336810A1

公开(公告)日：1995-05-18

申请号：DE4336810

申请日：1993-10-28

Applicant: BASF AG ,  RHEIN BIOTECH PROZ & PROD GMBH

Inventor： BOLLSCHWEILER CLAUS DR ,  GELLISSEN GERD DR ,  PIONTEK MICHAEL DR ,  SCHWEDEN JUERGEN DR ,  WEYDEMANN ULRIKE DR

IPC: C12N15/09 ,  C07K14/815 ,  C12N15/16 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  C07K14/39 ,  C07K14/395

Abstract: A process for the recombinant production of proteins in yeast comprises transforming the yeast with an expression cassette which comprises the following structural elements encoded:L-A-P-GENwhere L is a leader sequence of an animal peptide neurohormone, A is an adaptor producing an alpha-helix structure, P is a processing signal and GEN is a structural gene for the required protein.

公开(公告)号：DE3830734A1

公开(公告)日：1990-03-22

申请号：DE3830734

申请日：1988-09-09

Applicant: BASF AG

Inventor： BOLLSCHWEILER CLAUS DR ,  SCHMIDT MARTIN DR ,  STRUBE KARL-HERMANN DR ,  BALDINGER VERENA DR ,  SCHWARZ MARGARETE DR

IPC: C12N9/64 ,  A61K38/00 ,  A61K38/46 ,  A61P7/02 ,  C07K1/22 ,  C12N9/72 ,  C12N15/58

公开(公告)号：DE3815886A1

公开(公告)日：1989-11-09

申请号：DE3815886

申请日：1988-05-10

Applicant: BASF AG

Inventor： MUELLER-NEUMANN MARKUS DR ,  SCHMIDT MARTIN DR ,  BALDINGER VERENA DR ,  DOERPER THOMAS DR ,  BOLLSCHWEILER CLAUS DR

IPC: A61K38/00 ,  C12N9/72

Abstract: Polypeptides of the formula A-tPA1-111-X-tPA112-527, in which A, tPA1-111, X and tPA112-527 have the meaning stated in the description, and the preparation thereof are described. The polypeptides are suitable for controlling diseases.