公开(公告)号：DE19605126A1

公开(公告)日：1997-08-14

申请号：DE19605126

申请日：1996-02-12

Applicant: BASF AG

Inventor： BOLLSCHWEILER CLAUS DR ,  SCHMIDT MARTIN DR ,  RADITSCH MARTIN DR ,  RUEBSAMEN KLAUS DR ,  HOEFFKEN HANS WOLFGANG DR ,  SCHWEDEN JUERGEN DR ,  FRIEDRICH THOMAS DR

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C07K14/745 ,  A61K38/57 ,  C07H21/04 ,  A61K38/36

Abstract: The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：DE3930099A1

公开(公告)日：1991-02-21

申请号：DE3930099

申请日：1989-09-09

Applicant: BASF AG

Inventor： MUELLER-NEUMANN MARKUS DR ,  SCHMIDT MARTIN DR ,  STRUBE KARL-HERMANN DR ,  BALDINGER VERENA DR ,  SCHWARZ MARGARETE DR

IPC: C12N9/72

Abstract: (I) has one or two extra amino acids substd. or inserted in the 277-527th aminoacid region. Also claimed is a DNA sequence that codes for (I) and vectors contg. the appropriate gene sequence. The DNA sequence can be cloned from human uterine tissue, by isolating mRNA and transcribing into double-stranded cDNA. After inserting the cDNA into the conventional cloning vector pUC9, a cDNA library is built up. The cDNA clone can be isolated. USE/ADVANTAGE - In the treatment of thrombolysis, (I) has an improved clotting specificity, longer half life, lower inhiBitOr binding and/or h¦gher proteolytic activity than unmodified human tissue plasminogen activator.

公开(公告)号：CZ9601394A3

公开(公告)日：1997-10-15

申请号：CZ139496

申请日：1994-11-10

Applicant: BASF AG

Inventor： KROGER BURKHARD DR ,  SEULBERGER HARALD DR ,  MEYER THOMAS DR ,  SCHMIDT MARTIN DR ,  JACOB ELARD DR ,  OTTER RAINER DR ,  SUBKOWSKI THOMAS DR ,  HILLEN HEINZ DR

IPC: G01N33/573 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/43 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/57 ,  C12R1/91 ,  A01K67/027 ,  A61K38/48 ,  C07K16/40 ,  C12N15/11

CPC classification number: C12N9/6497 ,  A61K38/00 ,  C12Y304/24071

公开(公告)号：DE3823805A1

公开(公告)日：1990-01-18

申请号：DE3823805

申请日：1988-07-14

Applicant: BASF AG

Inventor： MUELLER-NEUMANN MARKUS DR ,  SCHMIDT MARTIN DR ,  SCHWARZ MARGARETE DR ,  BALDINGER VERENA DR ,  DOERPER THOMAS DR ,  STRUBE KARL-HERMANN DR ,  BIALOJAN SIEGFRIED DR

IPC: C12N9/64 ,  A61K38/46 ,  A61P7/02 ,  C12N9/72 ,  C12N15/57 ,  C12N15/58

公开(公告)号：DE4403665A1

公开(公告)日：1995-08-10

申请号：DE4403665

申请日：1994-02-07

Applicant: BASF AG

Inventor： KROEGER BURKHARD DR ,  SEULBERGER HARALD DR ,  SUBKOWSKI THOMAS DR ,  HILLEN HEINZ DR ,  JACOB ELARD DR ,  MEYER THOMAS DR ,  OTTER RAINER DR ,  SCHMIDT MARTIN DR

IPC: A61K38/00 ,  C12N9/64 ,  C12N9/00 ,  A61K38/55 ,  C12N15/52 ,  C12Q1/25

Abstract: An endothelin converting enzyme (ECE) having the 754 (bovine) or 753 (human) amino acid sequence shown in the specification, or functional fragments, is new. Also claimed is DNA defined as (a) coding for the ECE as above, (b) having the 2314 (bovine) or 2720 (human) nucleotide sequence given in the specification or complementary sequences, or (c) encoding proteins which are recognised by antibodies generated against ECE as above.

公开(公告)号：DE3831714A1

公开(公告)日：1990-03-22

申请号：DE3831714

申请日：1988-09-17

Applicant: BASF AG

Inventor： BACH ALFRED DR ,  SCHMIDT MARTIN DR ,  STRUBE KARL-HERMANN DR ,  BALDINGER VERENA DR ,  SCHWARZ MARGARETE DR

IPC: C12N15/09 ,  A61K38/46 ,  A61P7/02 ,  C07K1/22 ,  C12N9/64 ,  C12N9/72 ,  C12N15/58

Abstract: tPA-like polypeptides and their manufacture are described. The new polypeptides are suitable for use against diseases.

公开(公告)号：DE3830734A1

公开(公告)日：1990-03-22

申请号：DE3830734

申请日：1988-09-09

Applicant: BASF AG

Inventor： BOLLSCHWEILER CLAUS DR ,  SCHMIDT MARTIN DR ,  STRUBE KARL-HERMANN DR ,  BALDINGER VERENA DR ,  SCHWARZ MARGARETE DR

IPC: C12N9/64 ,  A61K38/00 ,  A61K38/46 ,  A61P7/02 ,  C07K1/22 ,  C12N9/72 ,  C12N15/58

公开(公告)号：DE3821757A1

公开(公告)日：1990-02-08

申请号：DE3821757

申请日：1988-06-28

Applicant: BASF AG

Inventor： MUELLER-NEUMANN MARKUS DR ,  SCHMIDT MARTIN DR ,  SCHWARZ MARGARETE DR ,  BALDINGER VERENA DR ,  DOERPER THOMAS DR ,  BOELLSCHWEILER CLAUS DR ,  STRUBE KARL-HERMANN DR ,  BIALOJAN SIEGFRIED DR

IPC: A61K38/00 ,  C12N9/72

Abstract: Polypeptides of the formula A-tPA1-111-X-tPA112-527, in which A, tPA1-111, X and tPA112-527 have the meaning indicated in the description, and their preparation are described. The polypeptides are suitable for controlling diseases.

公开(公告)号：DE3815886A1

公开(公告)日：1989-11-09

申请号：DE3815886

申请日：1988-05-10

Applicant: BASF AG

Inventor： MUELLER-NEUMANN MARKUS DR ,  SCHMIDT MARTIN DR ,  BALDINGER VERENA DR ,  DOERPER THOMAS DR ,  BOLLSCHWEILER CLAUS DR

IPC: A61K38/00 ,  C12N9/72

Abstract: Polypeptides of the formula A-tPA1-111-X-tPA112-527, in which A, tPA1-111, X and tPA112-527 have the meaning stated in the description, and the preparation thereof are described. The polypeptides are suitable for controlling diseases.

公开(公告)号：CZ139496A3

公开(公告)日：1997-10-15

申请号：CZ139496

申请日：1994-11-10

Applicant: BASF AG

Inventor： KROGER BURKHARD DR ,  SEULBERGER HARALD DR ,  MEYER THOMAS DR ,  SCHMIDT MARTIN DR ,  JACOB ELARD DR ,  OTTER RAINER DR ,  SUBKOWSKI THOMAS DR ,  HILLEN HEINZ DR

IPC: G01N33/573 ,  A01K67/027 ,  A61K31/70 ,  A61K35/12 ,  A61K38/00 ,  A61K38/43 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  C07H21/04 ,  C07K14/47 ,  C07K16/40 ,  C12N5/00 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/113 ,  C12N15/57 ,  C12R1/91 ,  C12N15/11

Abstract: PCT No. PCT/EP94/03706 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 10, 1994 PCT Pub. No. WO95/14095 PCT Pub. Date May 26, 1995The invention relates to endothelin-converting enzymes containing the polypeptide sequence described in SEQ. ID. NO. 30 or SEQ. ID. NO. 36 or functional fragments thereof, genes which code for such enzymes, and processes for producing the said enzymes and the use thereof.