公开(公告)号：JP2001278780A

公开(公告)日：2001-10-10

申请号：JP2001090976

申请日：2001-03-27

Applicant: BASF AG

Inventor： KOLTER KARL DR ,  SCHOENHERR MICHAEL ,  ASCHERL HERMANN

IPC: A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K9/52 ,  A61K31/5513 ,  A61K45/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

Abstract: PROBLEM TO BE SOLVED: To provide an oral dosage form delayedly releasing active ingredient(s) through floating on gastric juice. SOLUTION: This oral dosage form comprises (a) one or more active ingredient(s), (b) a formulated mixture of polyvinyl acetate and polyvinylpyrrolidone and (c) optionally, another excipient commonly used for producing oral dosage forms.

公开(公告)号：JP2001261754A

公开(公告)日：2001-09-26

申请号：JP2001032583

申请日：2001-02-08

Applicant: BASF AG

Inventor： ANGEL MAXIMILIAN ,  GOTSCHE MICHAEL ,  KOLTER KARL DR

IPC: A61K8/02 ,  A61K8/72 ,  A61K8/81 ,  A61K9/00 ,  A61K9/20 ,  A61K9/28 ,  A61K9/32 ,  A61K47/32 ,  A61K47/34 ,  C08F2/44 ,  C08F283/06 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To provide a safe method for producing a graft copolymer of a polyvinyl ester by which the utilization even in industrial uses can be made. SOLUTION: This method for producing the graft copolymer of the polyvinyl ester comprises polymerizing (a) at least one kind of a vinyl ester of an aliphatic 1-24C carboxylic acid in the presence of (b) a polyether which is solid at room temperature and having general formula I and, as necessary, (c) at least another kind of monomer by using a free radical organic initiator system in which a liquid polyalkylene glycol is used as a solvent for the free radical initiator system.

公开(公告)号：JPH10306041A

公开(公告)日：1998-11-17

申请号：JP5764698

申请日：1998-03-10

Applicant: BASF AG

Inventor： KOLTER KARL DR ,  TIEFENSEE KRISTIN DR ,  STADLER REINHOLD DR ,  ZEITZ KATRIN DR

IPC: A61K47/04 ,  A01N25/00 ,  A01N25/10 ,  A01N25/26 ,  A61K9/28 ,  A61K9/32 ,  A61K9/50 ,  A61K9/52 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38 ,  C05G5/00

Abstract: PROBLEM TO BE SOLVED: To obtain polymeric powder or polymeric granules comprising a water-insoluble polymer and a water-soluble polymer, completely re-dispersible, suitable for uniform coating of pharmaceutical or agrochemical dosage form and enabling the easily controllable release of active ingredient(s). SOLUTION: The re-dispersible polymeric powder or granules comprises (a) 10-95 wt.% of polyvinyl acetate, (b) 5-90 wt.% of an N-vinylpyrrolidone-contg. polymer, (c) 0-20 wt.% of another water-soluble or water-swellable substance and d) 0-20 wt.% of water-insoluble pulverizing agent, and in some cases, (e) other additive(s), so as to coat a pharmaceutical or agrochemical dosage form. The polymeric powder or granules ensures the controlled release of the active substance, epoxiconazole into soil for at least 6 months through a polyvinyl acetate/polyvinyl pyrrolidone coat.

公开(公告)号：JP2001327854A

公开(公告)日：2001-11-27

申请号：JP2001096232

申请日：2001-03-29

Applicant: BASF AG

Inventor： ANGEL MAXIMILIAN DR ,  KOLTER KARL DR ,  SANNER AXEL DR ,  GOTSCHE MICHAEL

IPC: A61K8/02 ,  A61K8/11 ,  A61K8/64 ,  A61K8/73 ,  A61K8/86 ,  A61K9/48 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  B01J13/14 ,  C08F8/12 ,  C08F283/06 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To provide a medicine administration type hard capsule superior to gelatin and many well-known alternative material. SOLUTION: The hard capsule contains (A) a polymer obtained by radical- polymerizing in the presence of at least one kind of a vinyl ester (a), a polyether-containing compound (b) and if necessary, one or more kinds of another copolymerizable monomer (c) and successively saponifying at least a part of the ester functional group of the raw material monomer (a). The hard capsule having molding stability superior than the conventional technique is manufactured.

公开(公告)号：JPH11222444A

公开(公告)日：1999-08-17

申请号：JP28645598

申请日：1998-10-08

Applicant: BASF AG

Inventor： NGUYEN KIM SON DR ,  SANNER AXEL DR ,  KOLTER KARL DR

IPC: A61K9/20 ,  A61K9/28 ,  A61K9/32 ,  A61K47/30 ,  A61K47/34

Abstract: PROBLEM TO BE SOLVED: To use a water-soluble or water-dispersible polyurethane. SOLUTION: A water-soluble or water-dispersible polyurethane comprising (a) 0.1-30 wt.% at least one kind of polyhydric alcohol, (b) 20-45 wt.% at least one kind of polyether polyol, (c) 10-45 wt.% at least one kind of diamine containing an ionic group, (d) 30-50 wt.% at least one kind of polyisocyanate and as necessary (e) the other additive is used. This polyurethane is suitable as low-viscosity coating or binder for medication form.

公开(公告)号：JPH10279637A

公开(公告)日：1998-10-20

申请号：JP7385798

申请日：1998-03-23

Applicant: BASF AG

Inventor： BLANKENBURG RAINER DR ,  SCHEHLMANN VOLKER DR ,  KOLTER KARL DR

IPC: C08F2/22 ,  A61K9/50 ,  C08F4/04 ,  C08F4/28 ,  C08F4/30 ,  C08F226/00

Abstract: PROBLEM TO BE SOLVED: To enable the production of a water-base copolymer dispersion in a medium essentially comprising water by subjecting a mixture comprising a water-soluble N-vinylated nonionic monomer having a specified water solubility and a major amt. of a hydrophobic monomer having a specified water solubility to free-radical, water-base emulsion polymn. SOLUTION: A monomer mixture comprising 10-70 wt.% N-vinylated nonionic monomer having a water solubility higher than 60 g/l at 25 deg.C and 30-90 wt.% monoethylenically unsatd. hydrophobic monomer having a water solubility lower than 60 g/l at 25 deg.C is polymerized. An N-vinyllactam is an esp. advantageous N-vinylated monomer. A water-soluble azo compd., an alkali or ammonium salt of peroxodisulfuric acid, and hydrogen peroxide are examples of an esp. advantageous polymn. initiator. Pref., at least 70% of the initiator is continuously fed in the form of a water soln. or a water-alcohol soln.

公开(公告)号：JP2002020319A

公开(公告)日：2002-01-23

申请号：JP2001177575

申请日：2001-06-12

Applicant: BASF AG

Inventor： KOLTER KARL DR ,  FLICK DIETER ,  ASCHERL HERMANN

IPC: A61K47/32 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K47/04 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61P3/02

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a granule containing an active component, having good physical properties, continuously releasing active components by tableting and convertible to a high-dose pharmaceutical preparation having good mechanical properties. SOLUTION: The method for the production of a solid peroral preparation continuously releasing the active component comprises the use of at least one kind of active component, a mixture of polyvinyl acetate and polyvinyl pyrrolidone, optionally a water-soluble polymer or an oleophilic additive and optionally other conventional excipient as the components of the preparation, the granulation of the mixture of at least a part of the above components by heating at 40-130 deg.C, the mixing of the obtained granule with conventional excipient and the tableting of the mixture.

公开(公告)号：JP2001329029A

公开(公告)日：2001-11-27

申请号：JP2001072868

申请日：2001-03-14

Applicant: BASF AG

Inventor： ANGEL MAXIMILIAN DR ,  KOLTER KARL DR ,  SANNER AXEL DR ,  GOTSCHE MICHAEL

IPC: A23P1/04 ,  A61K9/48 ,  A61K47/30 ,  C08F2/44 ,  C08F283/06 ,  C08F290/06 ,  C08J5/00 ,  C08K9/10 ,  C08L51/08 ,  C08L101/00 ,  C08L101/16

Abstract: PROBLEM TO BE SOLVED: To provide a material for soft capsules which can be obtained without the addition of an additional plasticizer and is better than gelatin or the like. SOLUTION: The soft capsules comprise (a) a polymer produced by polymerizing a vinyl ester in the presence of a polyether, if necessary (b) a structure- improving auxiliary, and if necessary (c) other conventional constituents.

公开(公告)号：JPH1067651A

公开(公告)日：1998-03-10

申请号：JP18794997

申请日：1997-07-14

Applicant: BASF AG

Inventor： KOLTER KARL DR ,  LANG SIEGFRIED DR ,  SCHMIDT PETER PROF ,  HUEHNE ANJA

IPC: A61K9/20 ,  A61K47/30

Abstract: PROBLEM TO BE SOLVED: To prepare an auxiliary agent for direct tableting, capable of rapidly disintegrating at a low dusting ratio and having a high uptake capacity for a hardly tableted ingredient in spite of a good fluidity and a good binding power possessed thereby in order to form a tablet having a moderate hardness. SOLUTION: This auxiliary agent for direct tableting (i.e., the one without containing an active substance) comprises the following mixture: (A) 75-98wt.%, preferably 89-93wt.% powdery cellulose suitable for tableting with (B) 1-15wt.%, preferably 2-6wt.% soluble polyvinylpyrrolidone and (C) 0.5-10wt.%, preferably 2-5wt.% insoluble polyvinylpyrrolidone.

公开(公告)号：JP2002248349A

公开(公告)日：2002-09-03

申请号：JP2001393756

申请日：2001-12-26

Applicant: BASF AG

Inventor： WITTELER HELMUT ,  DROHMANN CHRISTIAN ,  SANNER AXEL ,  SCHWEIKERT LONI ,  KOLTER KARL DR

IPC: B01D37/02 ,  B01J20/26 ,  C08F2/44 ,  C08F283/06 ,  C12H1/056

Abstract: PROBLEM TO BE SOLVED: To provide a filter aid which is used for filtering an aqueous liquid, has excellent filtration action and is suitable for a precoated filtration. SOLUTION: Such a particulate water-insoluble polymer preparation is used for the filter aid for filtering the aqueous liquid containing at least one polymer P constituted substantially of a hydrophilic polymer segment and a hydrophobic polymer segment.