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    PRODUCTION OF CHROMANOL DERIVATIVE
    2.
    发明专利
    PRODUCTION OF CHROMANOL DERIVATIVE 失效

    公开(公告)号：JP2000095776A

    公开(公告)日：2000-04-04

    申请号：JP26767299

    申请日：1999-09-21

    Applicant: BASF AG

    Inventor： BALDENIUS KAI-UWE DR ,  BOCKSTIEGEL BERNHARD DR ,  HAGEN IEEDIKKE ,  RUFF DETLEF DR ,  SIEDENBIEDEL CARSTEN DR ,  STUERMER RAINER DR

    IPC: C07D311/70 ,  C07D311/72

    Abstract: PROBLEM TO BE SOLVED: To economically and safely obtain the subject compound useful as a biological agent by reaction of a specific oxochromanol derivative with metallic zinc in the presence of an acid or the like to effect reduction of the derivative so as not to change the double bond form or the like in the unsaturated side chain by isomerization or the like. SOLUTION: This compound of formula II (e.g. γ-tocotrienol) is obtained by reaction of a 4-oxo-chromanol derivative of formula I ((n) is 1-10; R1 to R4 are each H or a 1-4C alkyl; R5 is H, a 1-4C alkyl or the like) (e.g. 4-oxo-γ- tocotrienol) with a metallic zinc pref. at 1-0 molar equivalent based on the compound of formula I in the presence of an acid or acid mixture (pref. hydrochloric acid) pref. in an organic solvent such as n-heptane pref. at 20-100 deg.C normally 10 min to 24 h to effect reduction of the derivative of formula I.

    PRODUCTION OF IMMOBILIZED LIPASE, ENZYME CATALYTIC OR ENANTIO-SELECTIVE CONVERSION OF SUCH LIPASE AND SUBSTRATE, PRODUCTION OF OPTICALLY ACTIVE COMPOUND AND USE OF IMMOBILIZED LIPASE
    3.
    发明专利
    PRODUCTION OF IMMOBILIZED LIPASE, ENZYME CATALYTIC OR ENANTIO-SELECTIVE CONVERSION OF SUCH LIPASE AND SUBSTRATE, PRODUCTION OF OPTICALLY ACTIVE COMPOUND AND USE OF IMMOBILIZED LIPASE 失效

    公开(公告)号：JP2001037475A

    公开(公告)日：2001-02-13

    申请号：JP2000205432

    申请日：2000-07-06

    Applicant: BASF AG

    Inventor： FRIEDRICH THOMAS DR ,  STUERMER RAINER DR

    IPC: C12N9/20 ,  C12N11/08 ,  C12P41/00 ,  C12R1/38

    Abstract: PROBLEM TO BE SOLVED: To obtain an immobilized lipase having a long effective life, easily being reactivated and useful for the production of an optically active compound by bringing a crude lipase solution in contact with polyolefin particles. SOLUTION: This immobilized lipase is obtained by bringing (A) a crude lipase solution of a cultured broth not containing cells obtained by culturing organisms producing the lipase and in some cases, subsequently dispersing and/or homogenizing the above organisms in a solution and subsequently removing cells, in contact with (B) polyolefin particles e.g. a polypropylene, etc., having 200-1,000 μm dimension, 0.05-0.5 μm pore dimension and 60-70% void ratio. Further, it is preferable to use bacteria such as Pseudomonas burkholderia, etc., and to produce an optically active compound by reacting a mixture of stereo isomeric compounds of substrates such as an alcohol, amine, etc., or a racemic compound in the presence of the immobilized lipase.

    CHIRAL COMPOUND
    4.
    发明专利
    CHIRAL COMPOUND 失效

    公开(公告)号：JPH1081690A

    公开(公告)日：1998-03-31

    申请号：JP14515597

    申请日：1997-06-03

    Applicant: BASF AG

    Inventor： STUERMER RAINER DR ,  OKUDA JUN PROF DR ,  RITTER KURT DR

    IPC: B01J31/22 ,  B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C7/00 ,  C07C209/52 ,  C07C211/27 ,  C07F5/00 ,  C07F5/02 ,  C07F5/06 ,  C07F7/00 ,  C07F7/28 ,  C07F9/00 ,  C07F9/6596 ,  C07F9/80 ,  C07F9/90 ,  C07F9/94 ,  C07F17/00

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound capable of being used as a catalyst for enantiomeric selective hydrogenation by a simple method. SOLUTION: A chiral compound of formula I [M is an element selected from titanium, zirconium, hafnium, etc.; X is F, Cl, Br, I, H, a 1-10C alkyl, etc.; R -R are each H, a (1-10C alkyl-substituted) five to seven-membered cycloalkyl, etc.; R is Ge, Sn, O, S, etc.; R , R are each a 1-10C alkyl, a 6-15C aryl, etc.; (n) is a number obtained by subtracting 2 from the atomic valency of the M], e.g. a compound of formula II. The compound of formula I is obtained by reacting a suitably substituted cyclopentadienyl with compounds of the formulas: R Z2 and MXn (Z is F, Cl, Br, I) and subsequently reacting the reaction product with a compound of formula III (R is H, an alkali metal, etc.). Thereby, the active catalyst component used for enantiomeric selective hydrogenation can be obtained by the simple method.

    METHOD FOR RACEMIZING OPTICALLY ACTIVE AMINE
    5.
    发明专利
    METHOD FOR RACEMIZING OPTICALLY ACTIVE AMINE 审中-公开

    公开(公告)号：JP2002226437A

    公开(公告)日：2002-08-14

    申请号：JP2001383504

    申请日：2001-12-17

    Applicant: BASF AG

    Inventor： FUNKE FRANK DR ,  LIANG SHELUE ,  KRAMER ANDREAS DR ,  STUERMER RAINER DR ,  HOEHN ARTHUR

    IPC: C07C209/00 ,  C07B55/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/00 ,  C07C213/02 ,  C07C217/08

    Abstract: PROBLEM TO BE SOLVED: To provide an improved profitable method for racemizing an optically active amine, by which the objective product having a high racemization degree can simultaneously be obtained in a high racemization yield (racemate yield). SOLUTION: This method for racemizing the optically active amine, comprising reacting an optically active amine represented by formula I (R1 and R2 are different from each other; R1, R2, and R3 are each an alkyl, a cycloalkyl, an arylalkyl, an aryl, a heteroaryl or a heterocyclic group; R3 may additionally be H; provided that the above-described groups each may have one or more substituents selected from alkyl groups, cycloalkyl groups, alkoxy groups, aryloxy groups, amino groups, alkylamino groups and dialkylamino groups) in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at an enhanced temperature, is characterized in that the catalyst contains copper and zinc oxide as active catalyst components and a carrying material.

    8.
    发明专利
    未知

    公开(公告)号：DK1094056T3

    公开(公告)日：2004-03-29

    申请号：DK00120644

    申请日：2000-09-21

    Applicant: BASF AG

    Inventor： SCHEIN KARIN DR ,  BALDENIUS KAI-UWE DR ,  SIEGEL WOLFGANG DR ,  STUERMER RAINER DR ,  RUFF DETLEF DR ,  JAEDICKE HAGEN DR

    IPC: C07B61/00 ,  C07C45/46 ,  C07C49/825 ,  C07C67/42 ,  C07C69/017 ,  C07C69/16

    Abstract: Preparation of monoacetylated hydroquinone compound comprises reacting a dicetylphenol compound with peroxo compounds optionally using an acid in one reaction step. Preparation of monoacetylated hydroquinone compound of formula (I) comprises reacting a dicetylphenol compound of formula (II) with peroxo compounds optionally using an acid. R1-R3 = H or Me. Independent claims are included for: (1) preparation of (II) by reacting phenol compounds of formula (III) with an acetylation agent using an acid catalyst; (2) preparation of monoacetylated hydroquinone compounds (I) by reacting (III) with an acetylation agent using an acid catalyst to give (II) and further reacting with peroxo compounds, optionally in the presence of an acid; and (3) compounds of formula (Ia)-(Ie).

    10.
    发明专利
    未知

    公开(公告)号：DE19642354A1

    公开(公告)日：1998-04-16

    申请号：DE19642354

    申请日：1996-10-14

    Applicant: BASF AG

    Inventor： GEPRAEGS MICHAEL DR ,  STUERMER RAINER DR ,  WEIS HORST DR ,  STEIGER SUSANNE

    IPC: C07F7/00 ,  C07F7/28 ,  C07F19/00 ,  C08F4/60 ,  C08F10/00 ,  C07F7/22 ,  C07F17/00

    Abstract: Disclosed are metal complexes of the general formula (I), in which the substituents have the following notations: M is a metal of the subgroup III, IV, V or VI in the periodic table of the elements or a metal of the lanthanide series; Y is a negative nucleofuge atom or a negative leaving group; X and X are neutral atoms or negatively loaded atoms from the main group IV, V or VI in the periodic table of the elements; Z is hydrogen, C1- to C10-alkyl, C3- to C10-cycloalkyl, C1- to C10-alkoxy, C1- to C10-alkylthiolat or dialkylamide with, in each case, 1 to 4 C-atoms in the alkyl residues; R to R are hydrogen, organocarbon or organosilicon residues, n is 0, 1 or 2, and the valence of M is (2+n).

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