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    Thermal reaction device and method for using the same
    2.
    发明专利
    Thermal reaction device and method for using the same 审中-公开
    热反应装置及其使用方法

    公开(公告)号：JP2012085659A

    公开(公告)日：2012-05-10

    申请号：JP2012020787

    申请日：2012-02-02

    Applicant: Fluidigm Corp ,  フルイディグム コーポレイション

    Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

    IPC: C12N15/09 ,  C12M1/00 ,  G01N37/00

    Abstract: PROBLEM TO BE SOLVED: To provide devices that can be utilized to conduct a variety of nucleic acid amplification reactions, while having sufficient versatility for use in other types of analyses as well.SOLUTION: An M×N matrix microfluidic device for performing a matrix of reactions is disclosed. This device (100) has a plurality of reaction cells (106) in communication with one of either a sample inlet (120) or a reagent inlet (124) through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of the microfluidic device. The method includes a step of using patterned photoresist masks and a step of etching regions or portions of an elastomeric layer of the elastomeric block.

    Abstract translation: 要解决的问题：提供可用于进行各种核酸扩增反应的装置，同时具有用于其它类型分析的足够多功能性。 解决方案：公开了一种用于执行反应矩阵的M×N矩阵微流体装置。 该装置（100）具有通过形成在装置的弹性体块内的通孔与样品入口（120）或试剂入口（124）中的一个连通的多个反应池（106）。 提供的方法包括在微流体装置的弹性体层中平行地形成通孔的方法。 该方法包括使用图案化的光致抗蚀剂掩模和蚀刻弹性体块的弹性层的区域或部分的步骤。 版权所有（C）2012，JPO＆INPIT

    Microfluidic device and method of using the same
    5.
    发明专利
    Microfluidic device and method of using the same 审中-公开
    微流体装置及其使用方法

    公开(公告)号：JP2011097955A

    公开(公告)日：2011-05-19

    申请号：JP2011027942

    申请日：2011-02-10

    Applicant: Fluidigm Corp ,  フルイディグム コーポレイション

    Inventor： MCBRIDE LINCOLN ,  MICHAEL RUSERO ,  UNGER MARC ,  NASSEF HANY RAMEZ ,  FACER GEOFFREY

    IPC: C12M1/00 ,  B01L3/00 ,  B01L3/02 ,  B01L7/00 ,  B01L99/00 ,  B81B20060101 ,  C12N15/09 ,  C12Q1/68 ,  G01N1/10 ,  G01N37/00

    CPC classification number: B01L3/00 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2200/142 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0638 ,  C12Q1/686

    Abstract: PROBLEM TO BE SOLVED: To provide a device which can be utilized to conduct a variety of nucleic acid amplification reactions, while having sufficient versatility for use in other types of analyses as well. SOLUTION: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping, and gene expression analyses. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供可用于进行各种核酸扩增反应的装置，同时具有用于其它类型分析的足够多功能性。 提供了各种基于弹性体的微流体装置和用于使用和制造这种装置的方法。 某些设备具有反应位置阵列以便于高通量分析。 一些装置还包括位于盲制通道末端的反应位置，在制造过程中试剂已经预先沉积。 一旦将样品引入反应部位，试剂就会悬浮。 该装置可以与各种加热装置一起使用，因此可用于需要温度控制的各种分析，包括热循环应用，如核酸扩增反应，基因分型和基因表达分析。 版权所有（C）2011，JPO＆INPIT

    MICROFLUIDIC DEVICES AND METHODS OF USING SAME
    10.
    发明专利
    MICROFLUIDIC DEVICES AND METHODS OF USING SAME 未知

    公开(公告)号：CA2807591C

    公开(公告)日：2014-11-18

    申请号：CA2807591

    申请日：2004-04-05

    Applicant: FLUIDIGM CORP

    Inventor： MCBRIDE LINCOLN ,  LUCERO MICHAEL ,  UNGER MARC ,  NASSEF HANY RAMEZ ,  FACER GEOFFREY

    IPC: C12M1/40 ,  B81B3/00 ,  B81B7/04 ,  C12M1/34 ,  C12M1/38 ,  C12P19/34 ,  C12Q1/68 ,  G01N1/00

    Abstract: Introducing a sample solution that includes a target nucleic acid polymer into a microfluidic device that has a sample region with: (i) a flow channel in fluid communication with one fluid inlet and one fluid outlet; and (ii) a plurality of valves that, when closed, partition the flow channel into isolated reaction sites. Each valve is formed from an elastomeric membrane that separates a control channel from the flow channel and which is disposed to be deflected into or retracted out from the flow channel in response to an actuation force to the control channel, thereby forming the valve. The method includes closing the valves, thereby partitioning the flow channel into isolated reaction sites containing portions of said sample solution; exposing the reaction sites to conditions under which the nucleic acid polymer is amplified to produce an amplification product; and opening said valves and displacing sample solution out of the flow channel.

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