公开(公告)号：JP2012085659A

公开(公告)日：2012-05-10

申请号：JP2012020787

申请日：2012-02-02

Applicant: Fluidigm Corp ,  フルイディグム コーポレイション

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

IPC: C12N15/09 ,  C12M1/00 ,  G01N37/00

Abstract: PROBLEM TO BE SOLVED: To provide devices that can be utilized to conduct a variety of nucleic acid amplification reactions, while having sufficient versatility for use in other types of analyses as well.SOLUTION: An M×N matrix microfluidic device for performing a matrix of reactions is disclosed. This device (100) has a plurality of reaction cells (106) in communication with one of either a sample inlet (120) or a reagent inlet (124) through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of the microfluidic device. The method includes a step of using patterned photoresist masks and a step of etching regions or portions of an elastomeric layer of the elastomeric block.

Abstract translation: 要解决的问题：提供可用于进行各种核酸扩增反应的装置，同时具有用于其它类型分析的足够多功能性。 解决方案：公开了一种用于执行反应矩阵的M×N矩阵微流体装置。 该装置（100）具有通过形成在装置的弹性体块内的通孔与样品入口（120）或试剂入口（124）中的一个连通的多个反应池（106）。 提供的方法包括在微流体装置的弹性体层中平行地形成通孔的方法。 该方法包括使用图案化的光致抗蚀剂掩模和蚀刻弹性体块的弹性层的区域或部分的步骤。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：WO2005107938A3

公开(公告)日：2006-01-12

申请号：PCT/US2005015352

申请日：2005-05-02

Applicant: FLUIDIGM CORP ,  GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

IPC: B01J3/00 ,  B01J4/00 ,  B01J10/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  B01L3/02 ,  G01N15/06 ,  G01N21/00 ,  G01N31/22

CPC classification number: B01L7/52 ,  B01J19/0046 ,  B01J2219/00353 ,  B01J2219/004 ,  B01J2219/00403 ,  B01J2219/00495 ,  B01J2219/00576 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/502738 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/1805 ,  B01L2400/0481 ,  B01L2400/0638

Abstract: An M x N matrix microfluidic device for performing a matrix of reactions, the device (100) having a plurality of reaction cells (106) in communication with one of either a sample inlet (120) or a reagent t inlet (124) through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method includes using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.

Abstract translation: 一种用于执行反应矩阵的M×N矩阵微流体装置，所述装置（100）具有多个反应池（106），其通过样品入口（120）或试剂t入口（124）中的一个通过 通过形成在装置的弹性体块内。 提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。

公开(公告)号：WO2006071470A2

公开(公告)日：2006-07-06

申请号：PCT/US2005044072

申请日：2005-12-05

Applicant: CALIFORNIA INST OF TECHN ,  FLUIDIGM CORP ,  UNIV CALIFORNIA ,  SIEMENS CORP ,  LEE CHUNG-CHENG ,  SUI GUODONG ,  ELIZAROV ARKADIJ ,  KOLB HARTMUTH C ,  HUANG JIANG ,  HEATH JAMES R ,  PHELPS MICHAEL E ,  QUAKE STEPHEN R ,  TSENG HSIAN-RONG ,  WYATT PAUL ,  DARIDON ANTOINE

Inventor： LEE CHUNG-CHENG ,  SUI GUODONG ,  ELIZAROV ARKADIJ ,  KOLB HARTMUTH C ,  HUANG JIANG ,  HEATH JAMES R ,  PHELPS MICHAEL E ,  QUAKE STEPHEN R ,  TSENG HSIAN-RONG ,  WYATT PAUL ,  DARIDON ANTOINE

CPC classification number: B01J19/0093 ,  B01F11/0042 ,  B01F13/0059 ,  B01F2215/0404 ,  B01J2219/00286 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00731 ,  B01J2219/00759 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01L3/5027 ,  B33Y80/00 ,  C07B59/00

Abstract: New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

Abstract translation: 提供了用于进行化学反应的新型微流体装置。 该器件适用于片上溶剂交换，需要多次化学反应的化学过程和试剂的快速浓缩。

公开(公告)号：DE60239328D1

公开(公告)日：2011-04-14

申请号：DE60239328

申请日：2002-04-05

Applicant: FLUIDIGM CORP

Inventor： HUANG JIANG ,  XIAO SHOUJUN ,  UNGER MARC A

IPC: B29C71/00 ,  G01N37/00 ,  A61L27/00 ,  B01J20/285 ,  B01L3/00 ,  B81B1/00 ,  C08F257/02 ,  C08F263/04 ,  C08F265/04 ,  C08F279/02 ,  C08F287/00 ,  C08F291/00 ,  C08J5/12 ,  C08J7/12 ,  C08K5/00 ,  C08L83/04 ,  C08L101/00 ,  F04B43/04 ,  H01J49/04

公开(公告)号：AT500051T

公开(公告)日：2011-03-15

申请号：AT02763970

申请日：2002-04-05

Applicant: FLUIDIGM CORP

Inventor： HUANG JIANG ,  XIAO SHOUJUN ,  UNGER MARC

IPC: B29C71/00 ,  G01N37/00 ,  A61L27/00 ,  B01J20/285 ,  B01L3/00 ,  B81B1/00 ,  C08F257/02 ,  C08F263/04 ,  C08F265/04 ,  C08F279/02 ,  C08F287/00 ,  C08F291/00 ,  C08J5/12 ,  C08J7/12 ,  C08K5/00 ,  C08L83/04 ,  C08L101/00 ,  F04B43/04 ,  H01J49/04

Abstract: The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between an intrinsic functional group that is present in the polymer and the functional group of the surface modifying compound. By using a polymer having an intrinsic functional group, a separate surface activation step is avoided.

公开(公告)号：SG166024A1

公开(公告)日：2010-11-29

申请号：SG2009028630

申请日：2005-05-02

Applicant: FLUIDIGM CORP

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

Abstract: An M x N matrix microfluidic device for performing a matrix of reactions, the device (100) having a plurality of reaction cells (106) in communication with one of either a sample inlet (120) or a reagent t inlet (124) through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method includes using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block. Fig. 1A

公开(公告)号：EP1838431A4

公开(公告)日：2012-08-22

申请号：EP05857049

申请日：2005-12-05

Applicant: CALIFORNIA INST OF TECHN ,  FLUIDIGM CORP ,  UNIV CALIFORNIA ,  SIEMENS CORP

Inventor： LEE CHUNG-CHENG ,  SUI GUODONG ,  ELIZAROV ARKADIJ ,  KOLB HARTMUTH C ,  HUANG JIANG ,  HEATH JAMES R ,  PHELPS MICHAEL E ,  QUAKE STEPHEN R ,  TSENG HSIAN-RONG ,  WYATT PAUL ,  DARIDON ANTOINE

IPC: B32B37/00 ,  B01F11/00 ,  B01F13/00 ,  B01J19/00 ,  B44C7/00 ,  C07B59/00

CPC classification number: B01J19/0093 ,  B01F11/0042 ,  B01F13/0059 ,  B01F2215/0404 ,  B01J2219/00286 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00731 ,  B01J2219/00759 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01L3/5027 ,  B33Y80/00 ,  C07B59/00

公开(公告)号：EP1385692A4

公开(公告)日：2004-04-21

申请号：EP02763970

申请日：2002-04-05

Applicant: FLUIDIGM CORP

Inventor： HUANG JIANG ,  XIAO SHOUJUN ,  UNGER MARC A

IPC: G01N37/00 ,  A61L27/00 ,  B01J20/285 ,  B01L3/00 ,  B81B1/00 ,  C08F257/02 ,  C08F263/04 ,  C08F265/04 ,  C08F279/02 ,  C08F287/00 ,  C08F291/00 ,  C08J5/12 ,  C08J7/12 ,  C08K5/00 ,  C08L83/04 ,  C08L101/00 ,  F04B43/04 ,  H01J49/04 ,  B29C71/00

CPC classification number: B32B3/26 ,  B01J20/285 ,  B01J20/286 ,  B01J20/327 ,  B01J20/3272 ,  B01J2220/54 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/16 ,  B01L2300/163 ,  C08F257/02 ,  C08F263/04 ,  C08F265/04 ,  C08F279/02 ,  C08F287/00 ,  C08F291/00 ,  C08J5/12 ,  C08J7/12 ,  F04B43/043 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/24661 ,  Y10T428/24744 ,  Y10T428/249953 ,  Y10T428/249958 ,  Y10T428/249978 ,  Y10T428/31663 ,  Y10T428/31667

Abstract: The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between an intrinsic functional group that is present in the polymer and the functional group of the surface modifying compound. By using a polymer having an intrinsic functional group, a separate surface activation step is avoided.

Abstract translation: 本发明涉及包含与表面改性化合物共价键合的表面的表面改性聚合物。 聚合物和表面改性化合物之间共价键的形成通过存在于聚合物中的固有官能团和表面改性化合物的官能团之间的反应来实现。 通过使用具有固有官能团的聚合物，避免了单独的表面活化步骤。

公开(公告)号：EP1796824A4

公开(公告)日：2016-10-19

申请号：EP05766055

申请日：2005-05-02

Applicant: FLUIDIGM CORP

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY

IPC: G01N21/00 ,  B01J3/00 ,  B01J4/00 ,  B01J10/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N15/06 ,  G01N31/22

CPC classification number: B01L7/52 ,  B01J19/0046 ,  B01J2219/00353 ,  B01J2219/004 ,  B01J2219/00403 ,  B01J2219/00495 ,  B01J2219/00576 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/502738 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/1805 ,  B01L2400/0481 ,  B01L2400/0638

公开(公告)号：SG2013006333A

公开(公告)日：2014-08-28

申请号：SG2013006333

申请日：2005-05-02

Applicant: FLUIDIGM CORP

Inventor： GOODSAID FEDERICO ,  UNGER MARC A ,  HUANG JIANG ,  QUAN EMERSON ,  GROSSMAN ROBERT ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIEPRZYK MARTIN ,  FACER GEOFFREY