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1.发明申请THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES 审中-公开噻吩并[3,2-d]嘧啶衍生物对蛋白激酶具有抑制活性
公开(公告)号：WO2011093684A3
公开(公告)日：2011-08-04
申请号：PCT/KR2011/000664
申请日：2011-01-31
Applicant: HANMI HOLDINGS CO., LTD. , KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION , SON, Jung Beom , JUNG, Seung Hyun , CHOI, Wha Il , JUNG, Young Hee , CHOI, Jae Yul , SONG, Ji Yeon , LEE, Kyu Hang , LEE, Jae Chul , KIM, Eun Young , AHN, Young Gil , KIM, Maeng Sup , CHOI, Hwan Geun , SIM, Tae Bo , HAM, Young Jin , PARK, Dong-sik , KIM, Hwan , KIM, Dong-Wook
Inventor： SON, Jung Beom , JUNG, Seung Hyun , CHOI, Wha Il , JUNG, Young Hee , CHOI, Jae Yul , SONG, Ji Yeon , LEE, Kyu Hang , LEE, Jae Chul , KIM, Eun Young , AHN, Young Gil , KIM, Maeng Sup , CHOI, Hwan Geun , SIM, Tae Bo , HAM, Young Jin , PARK, Dong-sik , KIM, Hwan , KIM, Dong-Wook
IPC: C07D495/04 , C07D495/14 , C07D409/14 , A61P35/00
Abstract: The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.
Abstract translation: 本发明涉及式（I）的噻吩并[3,2-d]嘧啶衍生物或其药学上可接受的盐，水合物或溶剂合物，其对蛋白激酶具有优异的抑制活性 以及包含它的药物组合物有效预防或治疗异常细胞生长疾病。
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2.发明申请BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE 审中-公开具有蛋白激酶抑制活性的双相异构体衍生物
公开(公告)号：WO2011093672A2
公开(公告)日：2011-08-04
申请号：PCT/KR2011/000615
申请日：2011-01-28
Applicant: HANMI PHARM. CO., LTD. , KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , JUNG, Seung Hyun , JUNG, Young Hee , CHOI, Wha Il , SON, Jung Beom , JEON, Eun Ju , YANG, In Ho , SONG, Tae Hun , LEE, Mi Kyoung , KO, Myoung Sil , AHN, Young Gil , KIM, Maeng Sup , HAM, Young Jin , SIM, Tae Bo , CHOI, Hwan Geun , HAH, Jung Mi , PARK, Dong-sik , KIM, Hwan
Inventor： JUNG, Seung Hyun , JUNG, Young Hee , CHOI, Wha Il , SON, Jung Beom , JEON, Eun Ju , YANG, In Ho , SONG, Tae Hun , LEE, Mi Kyoung , KO, Myoung Sil , AHN, Young Gil , KIM, Maeng Sup , HAM, Young Jin , SIM, Tae Bo , CHOI, Hwan Geun , HAH, Jung Mi , PARK, Dong-sik , KIM, Hwan
IPC: C07D487/04 , C07D495/04 , A61K31/519 , A61P43/00
CPC classification number: C07D495/04
Abstract: The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.
Abstract translation: 本发明涉及对蛋白激酶具有改善的抑制活性的新型双环杂芳基衍生物，其药学上可接受的盐，其水合物及其溶剂合物，以及用于预防或治疗异常细胞生长障碍的药物组合物， 活性成分。
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3.发明申请AMINOSTYRYLBENZOFURAN DERIVATIVES AS INHIBITORS AGAINST BETA-AMYLOID FIBRIL FORMATION, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开作为抗β-淀粉样蛋白形成的抑制剂的氨基苯酚苯并呋喃衍生物和包含其的药物组合物
公开(公告)号：WO2013147568A1
公开(公告)日：2013-10-03
申请号：PCT/KR2013/002699
申请日：2013-04-01
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： KIM, Dong Jin , YOO, Kyung Ho , KIM, Young Soo , PARK, Woong Seo , KANG, Yong Koo , KIM, Hye Yun , KIM, Yun Kyung , PARK, Ki Duk , KIM, Maeng Sup , SUH, Kwee Hyun , AHN, Young Gil
IPC: C07D413/12 , C07D307/86 , A61K31/421 , A61P25/00
CPC classification number: C07D413/12 , C07D307/81 , C07D405/12
Abstract: The present invention provides an aminostyrylbenzofuran compound of Formula (I), and a pharmaceutical composition comprising same. The pharmaceutical composition of the present invention comprising the compound of Formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof as an active ingredient can be useful for the prevention and treatment of degenerative brain diseases caused by accumulation of beta-amyloid.
Abstract translation: 本发明提供式（I）的氨基苯乙烯基苯并呋喃化合物和包含其的药物组合物。 包含式（I）化合物，其药学上可接受的盐，异构体，水合物和溶剂合物作为活性成分的本发明的药物组合物可用于预防和治疗由积累引起的退行性脑病 的β-淀粉样蛋白。
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4.发明申请COMPOUND FOR INHIBITING THE FORMATION OF BETA-AMYLOID FIBRIL, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开用于抑制形成β-淀粉样纤维的化合物，其制备方法和包含其的药物组合物
公开(公告)号：WO2008030072A1
公开(公告)日：2008-03-13
申请号：PCT/KR2007/004364
申请日：2007-09-10
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , HANMI PHARM. CO., LTD. , KIM, Dong Chan , KIM, Dong Jin , YOO, Kyung Ho , SHIN, Kye Jung , BYEON, Seong Rim , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , MOOK, Inhee
Inventor： KIM, Dong Chan , KIM, Dong Jin , YOO, Kyung Ho , SHIN, Kye Jung , BYEON, Seong Rim , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , MOOK, Inhee
IPC: C07D213/34
CPC classification number: C07D213/38 , C07D213/30
Abstract: The present invention relates to a novel compound which is effective in inhibiting the formation of beta-amyloid fibril in the brain, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
Abstract translation: 本发明涉及一种有效抑制脑中β-淀粉样蛋白原纤维形成的新型化合物及其制备方法，以及含有作为活性成分的药物组合物。
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5.发明申请
公开(公告)号：WO2005121144A1
公开(公告)日：2005-12-22
申请号：PCT/KR2005/001798
申请日：2005-06-14
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , YOO, Kyung Ho , KIM, Dong Jin , KANG, Yong Koo , LEE, Kyung Seok , LEE, Gwan Sun , KIM, Maeng Sup , KANG, Jae Hoon
Inventor： YOO, Kyung Ho , KIM, Dong Jin , KANG, Yong Koo , LEE, Kyung Seok , LEE, Gwan Sun , KIM, Maeng Sup , KANG, Jae Hoon
IPC: C07D477/20
CPC classification number: C07D477/20
Abstract: The present invention relates to a novel 1β-methylcarbapenem derivative, a process for the preparation thereof and a pharmaceutical composition comprising the 1β-methylcarbapenem derivative or a pharmaceutically acceptable salt thereof as an active antibacterial ingredient.
Abstract translation: 本发明涉及一种新型的β-甲基碳青霉烯类衍生物，其制备方法和药物组合物，其包含作为活性抗菌成分的β-甲基碳青霉烯衍生物或其药学上可接受的盐。
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Patent Agency Ranking6.发明申请STYRYLBENZOFURAN DERIVATIVES AS INHIBITORS FOR BETA-AMYLOID FIBRIL FORMATION AND PREPARATION METHOD THEREOF 审中-公开作为抗坏血酸纤维素形成的抑制剂的苯乙烯苯并呋喃衍生物及其制备方法
公开(公告)号：WO2009151299A2
公开(公告)日：2009-12-17
申请号：PCT/KR2009/003165
申请日：2009-06-12
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , HANMI PHARM. CO., LTD. , KIM, Dong Jin , YOO, Kyung Ho , BYUN, Ji Hun , KIM, YoungSoo , KIM, Hye Yun , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , LEE, Ji Hoon , LEE, Myoung-Hwan , HWANG, Hana , RYU, Jiyeon
Inventor： KIM, Dong Jin , YOO, Kyung Ho , BYUN, Ji Hun , KIM, YoungSoo , KIM, Hye Yun , LEE, Gwan Sun , KIM, Maeng Sup , AHN, Young Gil , LEE, Ji Hoon , LEE, Myoung-Hwan , HWANG, Hana , RYU, Jiyeon
IPC: C07D307/78
CPC classification number: C07D307/81 , C07D307/80
Abstract: The present invention relates to a novel compound which efficiently inhibits the formation of beta-amyloid fibrils in the brain to be useful for preventing or treating a degenerative brain disease, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
Abstract translation: 本发明涉及有效抑制脑中β-淀粉样蛋白原纤维形成以用于预防或治疗退行性脑病的新型化合物，其制备方法和含有该衍生物作为活性成分的药物组合物。
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7.发明公开
公开(公告)号：EP1765822A1
公开(公告)日：2007-03-28
申请号：EP05753525.4
申请日：2005-06-14
Applicant: Korea Institute of Science and Technology
Inventor： YOO, Kyung Ho, Gunyoung Apt. 104-1501 , KIM, D. J., Taereung Hyundai Hometwn Sweet 104-306 , KANG, Yong Koo, Gunyoung 3-cha Apt. , LEE, Kyung Seok , LEE, Gwan Sun , KIM, Maeng Sup , KANG, Jae Hoon
IPC: C07D477/20
CPC classification number: C07D477/20
Abstract: The present invention relates to a novel 1β-methylcarbapenem derivative, a process for the preparation thereof and a pharmaceutical composition comprising the 1β-methylcarbapenem derivative or a pharmaceutically acceptable salt thereof as an active antibacterial ingredient.
Abstract translation: 本发明涉及一种新的1β-甲基碳代青霉烯衍生物，其制备方法和含有1β-甲基碳代青霉烯衍生物或其药学上可接受的盐作为活性抗菌成分的药物组合物。
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8.发明授权THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES 有权噻吩并[3,2-d]嘧啶衍生物对蛋白激酶具有抑制活性
公开(公告)号：EP2528925B1
公开(公告)日：2017-07-05
申请号：EP11737323.3
申请日：2011-01-31
Applicant: Hanmi Science Co., Ltd. , Korea Institute of Science and Technology , Catholic University Industry Academic Cooperation Foundation
Inventor： SON, Jung Beom , JUNG, Seung Hyun , CHOI, Wha Il , JUNG, Young Hee , CHOI, Jae Yul , SONG, Ji Yeon , LEE, Kyu Hang , LEE, Jae Chul , KIM, Eun Young , AHN, Young Gil , KIM, Maeng Sup , CHOI, Hwan Geun , SIM, Tae Bo , HAM, Young Jin , PARK, Dong-sik , KIM, Hwan , KIM, Dong-Wook
IPC: C07D495/04 , C07D495/14 , C07D409/14 , A61P35/00
CPC classification number: C07D495/04
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9.发明公开THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES 有权带有锁定对蛋白激酶噻吩并[3,2-D]嘧啶衍生物
公开(公告)号：EP2528925A2
公开(公告)日：2012-12-05
申请号：EP11737323.3
申请日：2011-01-31
Applicant: Hanmi Science Co., Ltd. , Korea Institute of Science and Technology , Catholic University Industry Academic Cooperation
Inventor： SON, Jung Beom , JUNG, Seung Hyun , CHOI, Wha Il , JUNG, Young Hee , CHOI, Jae Yul , SONG, Ji Yeon , LEE, Kyu Hang , LEE, Jae Chul , KIM, Eun Young , AHN, Young Gil , KIM, Maeng Sup , CHOI, Hwan Geun , SIM, Tae Bo , HAM, Young Jin , PARK, Dong-sik , KIM, Hwan , KIM, Dong-Wook
IPC: C07D495/04 , C07D495/14 , C07D409/14 , A61P35/00
CPC classification number: C07D495/04
Abstract: The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.
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10.发明公开BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE 审中-公开具有锁定效应蛋白激酶双环杂芳基衍生物
公开(公告)号：EP2528920A2
公开(公告)日：2012-12-05
申请号：EP11737311.8
申请日：2011-01-28
Inventor： JUNG, Seung Hyun , JUNG, Young Hee , CHOI, Wha Il , SON, Jung Beom , JEON, Eun Ju , YANG, In Ho , SONG, Tae Hun , LEE, Mi Kyoung , KO, Myoung Sil , AHN, Young Gil , KIM, Maeng Sup , HAM, Young Jin , SIM, Tae Bo , CHOI, Hwan Geun , HAH, Jung Mi , PARK, Dong-sik , KIM, Hwan
IPC: C07D487/04 , C07D495/04 , A61K31/519 , A61P43/00
CPC classification number: C07D495/04
Abstract: The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.
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