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公开(公告)号：WO2013138724A3
公开(公告)日：2014-04-24
申请号：PCT/US2013032107
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL C , NURSE JAMES , LIM GARY , STRAUB THEODORE , FOSTER EVAN
IPC: B01L3/02
CPC classification number: G01N35/1002 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00351 , B01J2219/0038 , B01J2219/00599 , B01J2219/00619 , B01J2219/00637 , B01L3/5088 , B01L2200/0642 , B01L2200/12 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , B01L2300/165 , B01L2400/0406 , C40B60/14
Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85 +/- 15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.
Abstract translation: 提供了一种用于将液体样品加载到基底内的多个反应位点的样品装载器。 样品装载器包括第一叶片和联接到第一叶片的第二叶片。 样品装载器还包括在第一叶片和第二叶片之间的流动路径，其构造成将液体样品分配到包括多个反应位点的基底。 此外，在各种实施例中，液体样品与第一和第二叶片具有85 +/- 15度的前进接触角。 此外，从流动路径分配到多个反应位点的液体样品的装载可以基于毛细作用。
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公开(公告)号：WO2013138706A3
公开(公告)日：2014-01-16
申请号：PCT/US2013032002
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL , NURSE JAMES C , MAHER KEVIN , FONSECA JORGE , GHENCIU ELIODOR , FOSTER EVAN
CPC classification number: B01L3/50857 , B01L3/50 , B01L3/50851 , B01L2200/141 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , C12Q1/6806 , C12Q1/686 , G03F7/2002
Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.
Abstract translation: 用于保持多个生物样品的制品包括基材，其包含基材中的第一表面和相对的第二表面和多个反应位点。 每个反应位点从第一表面中的开口延伸到第二表面中的开口。 反应位点包括六边形形状并且被配置为通过毛细作用提供足够的表面张力以保持各自的生物样品。 反应部位的表面密度至少在每平方毫米170个孔以上。 至少一个表面可以具有由小于或等于5纳米的算术平均粗糙度（Ra）表征的表面粗糙度。
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公开(公告)号：AU2013231910A1
公开(公告)日：2014-10-30
申请号：AU2013231910
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL C , NURSE JAMES , LIM GARY , STRAUB THEODORE , GHENCIU ELIODOR , FOSTER EVAN , FONSECA JORGE , MAHER KEVIN
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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公开(公告)号：AU2014268299A1
公开(公告)日：2016-01-21
申请号：AU2014268299
申请日：2014-05-27
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL , FOSTER EVAN , FONSECA JORGE , NURSE JAMES , STRAUB THEODORE
IPC: B01L3/00
Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.
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公开(公告)号：SG11201406039WA
公开(公告)日：2014-11-27
申请号：SG11201406039W
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL , NURSE JAMES C , MAHER KEVIN , FONSECA JORGE , GHENCIU ELIODOR , FOSTER EVAN
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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Patent Agency Ranking
公开(公告)号：SG11201405788UA
公开(公告)日：2014-11-27
申请号：SG11201405788U
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor： GHENCIU ELIODOR , FOSTER EVAN , STRAUB THEODORE , PALLAS MICHAEL C
Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.
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公开(公告)号：AU2013231889A1
公开(公告)日：2014-10-30
申请号：AU2013231889
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor： GHENCIU ELIODOR , FOSTER EVAN , STRAUB THEODORE , PALLAS MICHAEL C
Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.
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公开(公告)号：IN8164DEN2014A
公开(公告)日：2015-05-01
申请号：IN8164DEN2014
申请日：2014-09-30
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL C , NURSE JAMES , LIM GARY , STRAUB THEODORE , FOSTER EVAN
IPC: B01L3/02
Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further in various embodiments the liquid sample has an advancing contact angle of 85 +/-15 degrees with the first and second blade. Furthermore loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.
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公开(公告)号：IN8136DEN2014A
公开(公告)日：2015-05-01
申请号：IN8136DEN2014
申请日：2014-09-29
Applicant: LIFE TECHNOLOGIES CORP
Inventor： GHENCIU ELIODOR , FOSTER EVAN , STRAUB THEODORE , PALLAS MICHAEL C
Abstract: An apparatus for biological reactions is provided. The apparatus includes a substrate and a plurality of reaction sites within the substrate. A surface of the substrate is configured to have a first hydrophilicity and each surface of the plurality of reaction sites is configured to have a second hydrophilicity to load a substantial number of reaction sites with a sample volume. The sample volume of each loaded reaction site is substantially confined to its respective reaction site. The sample volume is configured to undergo a biological reaction within the reaction site.
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公开(公告)号：IN8135DEN2014A
公开(公告)日：2015-05-01
申请号：IN8135DEN2014
申请日：2014-09-29
Applicant: LIFE TECHNOLOGIES CORP
Inventor： PALLAS MICHAEL C , NURSE JAMES , LIM GARY , STRAUB THEODORE , GHENCIU ELIODOR , FOSTER EVAN , FONSECA JORGE , MAHER KEVIN
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments the chip includes at least 20000 reaction sites. In other embodiments the chip includes at least 30000 reaction sites.
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