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公开(公告)号:WO2013049702A3
公开(公告)日:2013-10-10
申请号:PCT/US2012058096
申请日:2012-09-28
Applicant: LIFE TECHNOLOGIES CORP
Inventor: FREUDENTHAL JACOB K , DAHLHOFF GEOFFREY , MAHER KEVIN , CHEN MINGSONG , LIM GARY , DANEHY RONALD , FORTESCUE DAVID , SHEN MING , SOH WOON LIANG TERENCE , CHENG FRANCIS , WU RUOYUN , LEE THIAM CHYE , CHAPPELL GARY , LIM CHEE KIONG , DERE JEFF , STRAUB TED , FONSECA JORGE , BOO KUAN MOON , LAU SOO YONG
CPC classification number: C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样本保持器中的任何一个的可互换组件,每个相应样本保持器被配置为接收多个样本。 该系统还包括配置成循环多个样品通过一系列温度的控制系统。 该系统还包括配置成检测从多个样品发射的荧光信号的光学系统。 该光学系统尤其可以包括单个场透镜,激励源,光学传感器和多个滤波器组件。 激发源可以是一个或多个发光二极管。 场镜可以是双凸透镜。
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公开(公告)号:WO2013138724A3
公开(公告)日:2014-04-24
申请号:PCT/US2013032107
申请日:2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor: PALLAS MICHAEL C , NURSE JAMES , LIM GARY , STRAUB THEODORE , FOSTER EVAN
IPC: B01L3/02
CPC classification number: G01N35/1002 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00351 , B01J2219/0038 , B01J2219/00599 , B01J2219/00619 , B01J2219/00637 , B01L3/5088 , B01L2200/0642 , B01L2200/12 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , B01L2300/165 , B01L2400/0406 , C40B60/14
Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85 +/- 15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.
Abstract translation: 提供了一种用于将液体样品加载到基底内的多个反应位点的样品装载器。 样品装载器包括第一叶片和联接到第一叶片的第二叶片。 样品装载器还包括在第一叶片和第二叶片之间的流动路径,其构造成将液体样品分配到包括多个反应位点的基底。 此外,在各种实施例中,液体样品与第一和第二叶片具有85 +/- 15度的前进接触角。 此外,从流动路径分配到多个反应位点的液体样品的装载可以基于毛细作用。
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公开(公告)号:WO2013049702A2
公开(公告)日:2013-04-04
申请号:PCT/US2012058096
申请日:2012-09-28
Applicant: LIFE TECHNOLOGIES CORP
Inventor: FREUDENTHAL JACOB K , DAHLHOFF GEOFFREY , MAHER KEVIN , CHEN MINGSONG , LIM GARY , DANEHY RONALD , FORTESCUE DAVID , SHEN MING , SOH WOON LIANG TERENCE , CHENG FRANCIS , WU RUOYUN , LEE THIAM CHYE , CHAPPELL GARY , LIM CHEE KIONG , DERE JEFF , STRAUB TED , FONSECA JORGE , BOO KUAN MOON , LAU SOO YONG
CPC classification number: C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件,每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地,光学系统可以包括单个场透镜,激发源,光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。
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公开(公告)号:WO2013049659A3
公开(公告)日:2013-07-04
申请号:PCT/US2012058042
申请日:2012-09-28
Applicant: LIFE TECHNOLOGIES CORP
Inventor: DANEHY RONALD , LIM GARY , FREUDENTHAL JACOB
CPC classification number: C12Q1/6806 , B01L3/50851 , B01L3/50855 , B01L3/50857 , B01L2200/026 , B01L2200/0642 , B01L2200/0684 , B01L2200/142 , B01L2300/0819 , B01L2300/0829 , B01L2300/0858 , B01L2300/0893 , B01L2300/161 , C12M23/12 , C12M23/38
Abstract: A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface.
Abstract translation: 包含多个生物样品的情况包含基底,基底和覆盖物。 基底附着于基底并且包括构造成接收一种或多种生物样品的多个反应区域。 盖子包括内表面并且构造成附接到基座,使得基座和盖子一起提供包含基板的空腔。 内表面包括中心区域和围绕中心区域设置的凹陷区域。 中心区域构造成覆盖反应区域,而凹陷区域在垂直于内表面的方向上从中心区域偏移。
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公开(公告)号:SG11201908837UA
公开(公告)日:2019-10-30
申请号:SG11201908837U
申请日:2018-02-23
Applicant: LIFE TECHNOLOGIES CORP
Inventor: LIM GARY , LIU DAVID , LI PENG , CAO BIN , HIRANO KIRK , DUKHOVNY ALEXANDER , DIXON JOHN
IPC: G01N27/447
Abstract: 126 00 00 00 O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIP0 I PCT Hu omit VIII °nolo monim H moilowo oimIE (10) International Publication Number WO 2018/156880 Al (51) International Patent Classification: G01N 27/447 (2006.01) (21) International Application Number: PCT/US2018/019399 (22) International Filing Date: 23 February 2018 (23.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/463,467 24 February 2017 (24.02.2017) US (71) Applicant: LIFE TECHNOLOGIES CORPORATION [US/US]; 5823 Newton Drive, Carlsbad, California 92008 (US). (72) Inventors: LIM, Gary; Life Technologies Corporation, 5823 Newton Drive, Carlsbad, California 92009 (US). LIU, David; Life Technologies Corporation, 5823 Newton Dri- ve, Carlsbad, California 92009 (US). LI, Peng; 425 Smith Place, Ridgewood, New Jersey 07450 (US). CAO, Bin; Life Technologies Corporation, 5823 Newton Drive, Carls- bad, California 92009 (US). HIRANO, Kirk; Life Tech- nologies Corporation, 5823 Newton Drive, Carlsbad, Cal- ifornia 92009 (US). DUKHOVNY, Alexander; 570 Man- gels Ave., San Francisco, California 94127 (US). DIXON, John; P.O. Box 434, Moss Beach, California 94038 (US). (74) Agent: CHEN, Matthew; 5823 Newton Drive, Carlsbad, California 92008 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (54) Title: CAPILLARY ELECTROPHORESIS SYSTEMS, RELATED DEVICES, AND RELATED METHODS 100 FIG. 1 (57) : A biological analysis device (100) for performing capillary electrophoresis includes a voltage section (124) configured to generate a voltage differential across a cathode (106) connector and an anode (116) connector, an optical detector system (112) configured to detect light emission from a sample, a temperature regulation section (126), and a cartridge holding portion configured to receive at least a portion of a removable cartridge (102) comprising one or more capillaries (104) and a separation medium container (118). The biological analysis device may include one or more actuators (122) configured to actuate components of the removable cartridge when the removable cartridge is received in the cartridge holding portion. Devices and methods relate to biological analysis. [Continued on next page] WO 2018/156880 Al MIDEDIMOMOIDEIREEMOMMEMBEIHMEMOIMIE MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
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公开(公告)号:SG10201602113TA
公开(公告)日:2016-04-28
申请号:SG10201602113T
申请日:2012-09-28
Applicant: LIFE TECHNOLOGIES CORP
Inventor: FREUDENTHAL JACOB K , DAHLHOFF GEOFFREY , MAHER KEVIN , CHEN MINGSONG , LIM GARY , DANEHY RONALD , FORTESCUE DAVID , SHEN MING , SOH WOON LIANG TERENCE , CHENG FRANCIS , WU RUOYUN , LEE THIAM CHYE , CHAPPELL GARY , LIM CHEE KIONG , DERE JEFF , STRAUB TED , FONSECA JORGE , BOO KUAN MOON , LAU SOO YONG
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公开(公告)号:SG11201401911XA
公开(公告)日:2014-08-28
申请号:SG11201401911X
申请日:2012-09-28
Applicant: LIFE TECHNOLOGIES CORP
Inventor: DANEHY RONALD , LIM GARY , FREUDENTHAL JACOB
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公开(公告)号:IN8164DEN2014A
公开(公告)日:2015-05-01
申请号:IN8164DEN2014
申请日:2014-09-30
Applicant: LIFE TECHNOLOGIES CORP
Inventor: PALLAS MICHAEL C , NURSE JAMES , LIM GARY , STRAUB THEODORE , FOSTER EVAN
IPC: B01L3/02
Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further in various embodiments the liquid sample has an advancing contact angle of 85 +/-15 degrees with the first and second blade. Furthermore loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.
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公开(公告)号:IN8135DEN2014A
公开(公告)日:2015-05-01
申请号:IN8135DEN2014
申请日:2014-09-29
Applicant: LIFE TECHNOLOGIES CORP
Inventor: PALLAS MICHAEL C , NURSE JAMES , LIM GARY , STRAUB THEODORE , GHENCIU ELIODOR , FOSTER EVAN , FONSECA JORGE , MAHER KEVIN
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments the chip includes at least 20000 reaction sites. In other embodiments the chip includes at least 30000 reaction sites.
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公开(公告)号:SG11201605013PA
公开(公告)日:2016-07-28
申请号:SG11201605013P
申请日:2014-11-18
Applicant: LIFE TECHNOLOGIES CORP
Inventor: LIM GARY , STRAUB THEODORE
IPC: B01L3/02
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