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公开(公告)号:WO2011041703A3
公开(公告)日:2011-10-27
申请号:PCT/US2010051165
申请日:2010-10-01
Applicant: LIFE TECHNOLOGIES CORP , BREVNOV MAXIM G , NURSE JAMES C , STRAY JAMES
Inventor: BREVNOV MAXIM G , NURSE JAMES C , STRAY JAMES
CPC classification number: G01N1/4005 , G01N2001/4016
Abstract: A device for sample processing can include at least one chamber having an egress, said chamber being configured to receive a sample for processing, a filter through which at least some sample portions in the at least one chamber flow, and a barrier member disposed in a first state to contain sample in the at least one chamber. Upon sufficient conditions, the barrier member can be alterable to a second state to permit flow of at least some sample portions contained in the chamber in a flow direction toward the egress and through the filter.
Abstract translation: 用于样本处理的装置可以包括具有出口的至少一个腔室,所述腔室构造成接收用于处理的样本,过滤器,至少一个腔室中的至少一些样本部分流过所述过滤器,以及设置在 第一状态以将样品容纳在至少一个腔室中。 在足够的条件下,阻挡构件可以改变到第二状态,以允许容纳在腔室中的至少一些样品部分在流动方向上流向出口并且通过过滤器。
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公开(公告)号:DE602005024418D1
公开(公告)日:2010-12-09
申请号:DE602005024418
申请日:2005-08-26
Applicant: LIFE TECHNOLOGIES CORP
Inventor: VANN CHARLES S , BANERJEE DEBJYOTI , GEISER TIMOTHY G , NURSE JAMES C , BEARD NIGEL P
IPC: B01L3/02
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公开(公告)号:SG11201406039WA
公开(公告)日:2014-11-27
申请号:SG11201406039W
申请日:2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor: PALLAS MICHAEL , NURSE JAMES C , MAHER KEVIN , FONSECA JORGE , GHENCIU ELIODOR , FOSTER EVAN
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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公开(公告)号:AT485888T
公开(公告)日:2010-11-15
申请号:AT05791667
申请日:2005-08-26
Applicant: LIFE TECHNOLOGIES CORP
Inventor: VANN CHARLES S , BANERJEE DEBJYOTI , GEISER TIMOTHY G , NURSE JAMES C , BEARD NIGEL P
IPC: B01L3/02
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公开(公告)号:WO2013138706A3
公开(公告)日:2014-01-16
申请号:PCT/US2013032002
申请日:2013-03-15
Applicant: LIFE TECHNOLOGIES CORP
Inventor: PALLAS MICHAEL , NURSE JAMES C , MAHER KEVIN , FONSECA JORGE , GHENCIU ELIODOR , FOSTER EVAN
CPC classification number: B01L3/50857 , B01L3/50 , B01L3/50851 , B01L2200/141 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , C12Q1/6806 , C12Q1/686 , G03F7/2002
Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.
Abstract translation: 用于保持多个生物样品的制品包括基材,其包含基材中的第一表面和相对的第二表面和多个反应位点。 每个反应位点从第一表面中的开口延伸到第二表面中的开口。 反应位点包括六边形形状并且被配置为通过毛细作用提供足够的表面张力以保持各自的生物样品。 反应部位的表面密度至少在每平方毫米170个孔以上。 至少一个表面可以具有由小于或等于5纳米的算术平均粗糙度(Ra)表征的表面粗糙度。
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公开(公告)号:EP2046940A4
公开(公告)日:2011-08-10
申请号:EP07809900
申请日:2007-06-26
Applicant: LIFE TECHNOLOGIES CORP
Inventor: HIRANO KIRK M , BABCOKE JASON E , CARRILLO ALBERT L , HAGA DOUWE D , KAO PIN , KINNEY PATRICK D , NURSE JAMES C
IPC: C12M1/02
CPC classification number: B01L7/52 , B01L3/50851 , B01L3/50853 , B01L3/50857 , B01L7/00 , B01L2200/0605 , B01L2200/0642 , B01L2300/0654 , B01L2300/0829 , B01L2300/1816 , B01L2300/1838 , B01L2300/1861 , B01L2300/1872 , F28F13/00 , F28F2013/001 , G01N21/0332 , G01N21/6452 , G01N2201/062 , H05B3/84 , H05B6/02 , H05B6/105
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公开(公告)号:EP2040983A4
公开(公告)日:2011-08-03
申请号:EP07809899
申请日:2007-06-26
Applicant: LIFE TECHNOLOGIES CORP
Inventor: HIRANO KIRK M , NURSE JAMES C , CARRILLO ALBERT L , LU MIKE Y , FAWCETT ADRIAN
IPC: B65B7/28
CPC classification number: G01N35/028 , B01L3/50851 , B01L3/50853 , B01L3/563 , B01L7/52 , B01L2200/0605 , B01L2200/0642 , B01L2200/142 , B01L2300/041 , B01L2300/044 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/0864 , B01L2300/1822 , B01L2300/1827 , B01L2300/1872 , B01L2400/0406 , B01L2400/0487 , G01N2035/00287
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