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    ANTICONVULSANT ENANTIOMERIC AMINO ACID DERIVATIVES
    1.
    发明申请
    ANTICONVULSANT ENANTIOMERIC AMINO ACID DERIVATIVES 审中-公开
    有毒有机氨基酸衍生物

    公开(公告)号：WO1997033861A1

    公开(公告)日：1997-09-18

    申请号：PCT/US1997004579

    申请日：1997-03-17

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  KOHN, Harold

    IPC: C07C237/22

    CPC classification number: C07C237/22 ,  A61K31/165 ,  C07B2200/07

    Abstract: The present invention is directed to a compound in the R configuration about the asymmetric carbon in formula (I), wherein Ar is phenyl which is unsubstituted or substituted with at least one halo group; Q is lower alkoxy, and Q1 is methyl; pharmaceutical compositions containing same and the use thereof in treating CNS disorders in animals.

    Abstract translation: 本发明涉及R构型中关于式（I）中不对称碳的化合物，其中Ar是未被取代或被至少一个卤素取代的苯基; Q是低级烷氧基，Q 1是甲基; 含有它们的药物组合物及其在治疗动物中的CNS紊乱中的用途。

    2-IMINOCHROMENE DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE KINASE
    2.
    发明申请
    2-IMINOCHROMENE DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE KINASE 审中-公开
    作为蛋白酪氨酸激酶的抑制剂的2-亚硝基衍生物

    公开(公告)号：WO1996040670A1

    公开(公告)日：1996-12-19

    申请号：PCT/US1996007295

    申请日：1996-05-21

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  HUANG, Chi-Kuang

    IPC: C07D311/58

    CPC classification number: A61K31/352 ,  C07D311/58

    Abstract: Protein tyrosine kinase inhibitors are provided of formula (I), wherein R is H, OH, halo or O(C1-C4)alkyl; R is OH, halo or O(C1-C4)alkyl; R is (II), wherein R is H, OH, halo, CH2OH, C(O)CH3, C(O)N(R)2 wherein each R is H or (C1-C4)alkyl; or C(O)R wherein R is OH or O(C1-C4)alkyl; and R is OH, CH2OH, C(O)CH3, C(O)N(R)2 or C(O)R ; or a pharmaceutically acceptable salt thereof, which inhibit the pathological proliferation or growth of mammalian cells, such as cancer cells.

    Abstract translation: 蛋白酪氨酸激酶抑制剂由式（I）提供，其中R 2是H，OH，卤素或O（C 1 -C 4）烷基; R 2是OH，卤素或O（C 1 -C 4）烷基; R 1是（II），其中R 4是H，OH，卤素，CH 2 OH，C（O）CH 3，C（O）N（R）2，其中每个R是H或（C 1 -C 4）烷基 ; 或C（O）R，其中R 6为OH或O（C 1 -C 4）烷基; 和R 5是OH，CH 2 OH，C（O）CH 3，C（O）N（R）2或C（O）R 6; 或其药学上可接受的盐，其抑制哺乳动物细胞如癌细胞的病理增殖或生长。

    USE OF CYCLODEXTRINS FOR PROTEIN RENATURATION
    3.
    发明申请
    USE OF CYCLODEXTRINS FOR PROTEIN RENATURATION 审中-公开
    环孢菌素用于蛋白质还原的应用

    公开(公告)号：WO1996038468A1

    公开(公告)日：1996-12-05

    申请号：PCT/US1996005408

    申请日：1996-04-17

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  SHARMA, Ajit ,  KARUPPIAH, Nadarajah

    IPC: C07K01/113

    CPC classification number: C07K1/1136

    Abstract: A method for renaturing a denaturated protein is provided comprising contacting a solution or suspension of said denatured protein in a detergent-free liquid medium with an amount of a cyclodextrin effective to renature said protein, and optionally, recovering the renatured protein in essentially pure form.

    Abstract translation: 提供了一种用于变性变性蛋白质的方法，包括将所述变性蛋白质的溶液或悬浮液与不含洗涤剂的液体培养基接触，所述溶液或悬浮液与一定量的能有效地使所述蛋白质复性的环糊精，和任选以基本上纯的形式回收复性蛋白质。

    METHODS OF TREATING INFLAMMATION AND COMPOSITIONS THEREFOR
    4.
    发明申请
    METHODS OF TREATING INFLAMMATION AND COMPOSITIONS THEREFOR 审中-公开
    治疗炎症的方法及其组合物

    公开(公告)号：WO1996030042A2

    公开(公告)日：1996-10-03

    申请号：PCT/US1996004054

    申请日：1996-03-26

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  McFADDEN, D., Grant ,  LUCAS, Alexandra

    IPC: A61K38/57

    CPC classification number: A61K38/55 ,  C07K14/8121

    Abstract: Compositions and methods for treating inflammatory cell infiltration in a tissue of a mammalian subject are provided. The method involves administering a therapeutically effective amount of SERP-1, SERP-1 analog or biologically active fragment thereof admixed with a pharmaceutically acceptable carrier to a subject in need of such treatment. Biologically active SERP-1 analogs are also provided. The compositions and methods of the present invention are useful for treating numerous inflammatory based diseases and injuries.

    Abstract translation: 提供了用于治疗哺乳动物受试者的组织中的炎性细胞浸润的组合物和方法。 该方法包括给予需要这种治疗的受试者施用治疗有效量的与药学上可接受的载体混合的SERP-1，SERP-1类似物或其生物活性片段。 还提供了生物活性的SERP-1类似物。 本发明的组合物和方法可用于治疗许多基于炎症的疾病和损伤。

    STEM-LOOP AND CIRCULAR OLIGONUCLEOTIDES
    5.
    发明申请
    STEM-LOOP AND CIRCULAR OLIGONUCLEOTIDES 审中-公开
    STEM-LOOP和CIRCULAR OLIGONUCLEOTIDES

    公开(公告)号：WO1996029097A1

    公开(公告)日：1996-09-26

    申请号：PCT/US1995003602

    申请日：1995-03-21

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  KOOL, Eric, T.

    IPC: A61K48/00

    CPC classification number: C12N15/113 ,  C07H21/00 ,  C12N2310/111 ,  C12N2310/152 ,  C12N2310/53 ,  C12Q1/6813 ,  C12Q1/6839 ,  C12Q1/686

    Abstract: The present invention provides stem-loop and circular oligonucleotides each with at least one Watson-Crick binding (WC) domain and at least one corresponding Hoogsteen binding (H) domain separated from each other by linker domains. Each WC domain has sufficient complementarity to bind to one strand of a defined nucleic acid target by Watson-Crick base pairing in an anti-parallel orientation. Each corresponding H domain is capable of binding to the WC domain by Hoogsteen base pairing in an anti-parallel manner. The present invention also provides methods of making and using these oligonucleotides as well as kits and pharmaceutical compositions containing these oligonucleotides.

    Abstract translation: 本发明提供了茎环和环状寡核苷酸，每个具有至少一个Watson-Crick结合（WC）结构域和至少一个相应的Hoogsteen结合（H）结构域，其通过接头结构域彼此分离。 每个WC结构域具有足够的互补性，以反平行取向通过Watson-Crick碱基配对结合所定义的核酸靶的一条链。 每个相应的H结构域能够以反平行方式通过Hoogsteen碱基配对结合到WC结构域。 本发明还提供制备和使用这些寡核苷酸的方法以及含有这些寡核苷酸的试剂盒和药物组合物。

    LAG1: A GENE FOR INCREASING THE LONGEVITY OF EUKARYOTES
    9.
    发明申请
    LAG1: A GENE FOR INCREASING THE LONGEVITY OF EUKARYOTES 审中-公开
    LAG1：增加毒素的长度的基因

    公开(公告)号：WO1995033834A1

    公开(公告)日：1995-12-14

    申请号：PCT/US1995006725

    申请日：1995-06-02

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  JAZWINSKI, S., Michal

    IPC: C12N15/31

    CPC classification number: C07K14/395 ,  A61K38/00 ,  C07K14/47

    Abstract: The present invention provides a unique eukaryotic gene, called LAG1 , which controls the longevity of eukaryotic cells. According to the present invention, over expression of LAG1 in older cells has a rejuvenating effect which not only increases cellular life span but also reproductive capacity and cellular tolerance to stress factors such as starvation and low pH. Moreover, the present invention identifies two domains in LAG1 one having a life span limiting function and the other a life span extending function. Hence, according to the present invention, the longevity and tolerance to stress of cells is increased when provided with the wild type polypeptide or mutant LAG1 polypeptides which, for example, lack the "life span limiting domain".

    Abstract translation: 本发明提供了一种独特的真核基因，称为LAG1，其控制真核细胞的寿命。 根据本发明，老年细胞中LAG1的过度表达具有恢复活力，其不仅增加细胞寿命，而且增加生殖能力和对胁迫因子如饥饿和低pH的细胞耐受性。 此外，本发明鉴定了具有寿命限制功能的LAG1中的两个结构域，另一个确定寿命延长功能。 因此，根据本发明，当提供野生型多肽或突变型LAG1多肽（例如缺少“寿命限制结构域”）时，细胞的寿命和耐受性增加。

    STREPTOCOCCUS PNEUMONIAE HEMIN/HEMOGLOBIN-BINDING ANTIGENS
    10.
    发明申请
    STREPTOCOCCUS PNEUMONIAE HEMIN/HEMOGLOBIN-BINDING ANTIGENS 审中-公开
    结核分枝杆菌HEMIN / HEMOGLOBIN-BINDING抗原

    公开(公告)号：WO1995014712A1

    公开(公告)日：1995-06-01

    申请号：PCT/US1994013501

    申请日：1994-11-22

    Applicant: RESEARCH CORPORATION TECHNOLOGIES, INC.

    Inventor： RESEARCH CORPORATION TECHNOLOGIES, INC. ,  TAI, Stanley, Shih-Peng ,  WINTER, Ruth, Elisabeth

    IPC: C07K14/315

    CPC classification number: C07K14/3156 ,  A61K39/00 ,  Y10S435/885 ,  Y10S435/975

    Abstract: The present invention relates to the isolation of newly discovered hemin/hemoglobin-binding proteins of Streptococcus pneumoniae with approximate molecular weights of 18, 43, 55, 66 and 76 kDa, respectively, thereby providing bacterial-derived antigens and active derivatives and parts thereof, useful in the diagnostic assays, vaccines and pharmaceutical compositions relative to these bacteria. In addition, the present invention is directed to polyclonal and monoclonal antibodies directed to the hemin/hemoglobin-binding proteins of Streptococcus pneumoniae . The present invention further relates to methods of diagnosing and treating human pneumococcal infections including kits therefor.

    Abstract translation: 本发明涉及分离近似分子量为18,43,55,66和76kDa的新发现的肺炎链球菌血红蛋白/血红蛋白结合蛋白，从而提供细菌衍生的抗原 以及其在诊断测定中有用的活性衍生物及其部分，疫苗和相对于这些细菌的药物组合物。 此外，本发明涉及针对肺炎链球菌的血红素/血红蛋白结合蛋白的多克隆和单克隆抗体。 本发明还涉及诊断和治疗人肺炎球菌感染的方法，包括其用途。

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