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    ANTI-CLOGGING AND ANTI-ADHESIVE MICRO-CAPILLARY NEEDLE WITH ENHANCED TIP VISIBILITY
    1.
    发明公开
    ANTI-CLOGGING AND ANTI-ADHESIVE MICRO-CAPILLARY NEEDLE WITH ENHANCED TIP VISIBILITY 审中-公开

    公开(公告)号：US20230248953A1

    公开(公告)日：2023-08-10

    申请号：US18135775

    申请日：2023-04-18

    Applicant: Kinneret Rand

    Inventor： Kinneret Rand

    IPC: A61M37/00

    CPC classification number: A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2201/057 ,  B33Y80/00

    Abstract: An object of the present invention is to provide an anti-adhesive/anti-clogging and/or color marked/tinted micro-capillary tube (microtube), microneedle, or micropipette. Typically, the color/tint will be selected such that the tip of the microneedle or micropipette is in contrast (e.g., visually) to the biological material. The tint/color may be selected to contrast the stained biological material. In some aspects, the color mark comprises nanoparticles that are modified by adding a non-adhesive coating/material that minimizes protein adhesion/adsorption. The microtubes and/or micropipettes may be treated with an anti-clogging reagent and an anti-adhesive reagent to prevent or reduce clogging and adhesion of the micropipette or microneedle to biological materials. The microtubes and/or micropipettes may be formed using additive printing processes and additive manufacturing techniques or from micropipette and microneedle pullers.

    A METHOD OF MANUFACTURING A PLURALITY OF THROUGH-HOLES IN A LAYER
    3.
    发明公开
    A METHOD OF MANUFACTURING A PLURALITY OF THROUGH-HOLES IN A LAYER 审中-公开
    一种在一层中制造多个通孔的方法

    公开(公告)号：EP3210937A1

    公开(公告)日：2017-08-30

    申请号：EP17158214.1

    申请日：2017-02-27

    Applicant: SmartTip B.V.

    Inventor： SARAJLIC, Edin

    IPC: B81C1/00 ,  A61B5/15

    CPC classification number: B81C1/0015 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150511 ,  A61B5/150519 ,  A61B5/150984 ,  A61B5/15142 ,  A61M37/0015 ,  B81B2201/057 ,  B81B2201/12 ,  B81B2203/0118 ,  B81B2203/0353 ,  B81C1/00087 ,  B81C1/00111 ,  B81C1/00119 ,  B81C2201/0132 ,  B81C2201/0143 ,  B81C2201/0159 ,  B81C2201/0198 ,  C01B21/0687

    Abstract: A method of manufacturing a plurality of through-holes (132) in a layer of first material, for example for the manufacturing of a probe (100) comprising a tip containing a channel. To manufacture the through-holes (132) in a batch process,
    - a layer of first material is deposited on a wafer (200) comprising a plurality of pits (210)
    - a second layer is provided on the layer of first material, and the second layer is provided with a plurality of holes at central locations of the pits (210);
    - using the second layer as a shadow mask when depositing a third layer (240) at an angle, covering a part of the first material with said third material (240) at the central locations, and
    - etching the exposed parts of the first layer using the third layer (240) as a protective layer.

    Abstract translation: 一种在第一材料层中制造多个通孔（132）的方法，例如用于制造包括包含通道的尖端的探针（100）。 为了以间歇工艺制造通孔（132）， - 在包括多个凹坑（210）的晶片（200）上沉积第一材料层 - 在第一材料层上提供第二层，以及 第二层在凹坑（210）的中心位置设置有多个孔; - 当以一定角度沉积第三层（240）时，使用第二层作为阴影掩模，在中心位置处用所述第三材料（240）覆盖第一材料的一部分，以及 - 蚀刻第一层 使用第三层（240）作为保护层。

    A METHOD OF MANUFACTURING A PROBE COMPRISING A CANTILEVER WITH A CONDUIT
    4.
    发明申请
    A METHOD OF MANUFACTURING A PROBE COMPRISING A CANTILEVER WITH A CONDUIT 审中-公开
    制造包含CANTILEVER的探测器的方法

    公开(公告)号：WO2012096571A1

    公开(公告)日：2012-07-19

    申请号：PCT/NL2012/000007

    申请日：2012-01-13

    Applicant: SMARTTIP BV ,  SARAJLIC, Edin

    Inventor： SARAJLIC, Edin

    IPC: B81C1/00 ,  B01L3/00

    CPC classification number: G01R3/00 ,  B01L3/502707 ,  B81B2201/057 ,  B81B2203/0118 ,  B81B2203/0338 ,  B81C1/00119 ,  B81C2201/0109 ,  Y10T29/49002

    Abstract: The present invention relates to a method of manufacturing a probe comprising a cantilever with a conduit. According to the invention, an etchant window is provided in a layer covering an elongated sacrificial conduit core that is to form the conduit. This allows for an etching process where the elongated sacrificial conduit core is etched away before all material of a substrate is etched away, the remaining material of the substrate material making the probe stronger without being in the way during use of the probe.

    Abstract translation: 本发明涉及一种制造探针的方法，该探针包括具有导管的悬臂。 根据本发明，在覆盖要形成导管的细长牺牲导管芯的层中提供蚀刻剂窗口。 这允许蚀刻工艺，其中在衬底的所有材料被蚀刻掉之前，细长的牺牲导管芯被蚀刻掉，使衬底材料的剩余材料在探针的使用期间不会妨碍探针。

    MICRO-MACHINED NOZZLES
    5.
    发明申请
    MICRO-MACHINED NOZZLES 审中-公开
    微机喷嘴

    公开(公告)号：WO2006060195A1

    公开(公告)日：2006-06-08

    申请号：PCT/US2005/041936

    申请日：2005-11-18

    Applicant: AGILENT TECHNOLOGIES, INC.

    Inventor： BEERLING, Timothy ,  AIMI, Marco

    IPC: B41J2/14

    CPC classification number: B01L3/0262 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2400/0487 ,  B81B1/004 ,  B81B2201/057 ,  B81B2201/058 ,  B81B2203/0353 ,  H01H11/02 ,  H01H2029/008 ,  Y10T428/24273 ,  Y10T428/2902

    Abstract: A micro-machined nozzle includes a substrate (12) having a hole (14) formed on a first side (12a) that extends partially through a thickness dimension of the substrate (12) and a nozzle orifice (16) formed on a second opposite side (12b) that communicates with the hole (14). The nozzle orifice (16) has at least a portion of its interior wall serrated. A method of fabricating a micro-machined nozzle includes the steps of etching a first side (12a) of a silicon substrate (12) to form a hole (14) that extends partially through a thickness dimension of the substrate (12) and etching a second opposite side (12b) of the silicon substrate (12) to form a serrated nozzle orifice (16) that communicates with the hole (14).

    Abstract translation: 微加工喷嘴包括具有孔（14）的基底（12），所述孔（14）形成在部分延伸穿过基底（12）的厚度尺寸的第一侧（12a）上;以及喷嘴孔（16），形成在第二相对 （12b）与孔（14）连通。 喷嘴孔（16）具有其内壁的至少一部分锯齿状。 一种制造微加工喷嘴的方法包括以下步骤：蚀刻硅衬底（12）的第一侧（12a）以形成部分延伸穿过衬底（12）的厚度尺寸并且蚀刻 所述硅衬底（12）的第二相对侧（12b）形成与所述孔（14）连通的锯齿形喷嘴孔口（16）。

    Anti-clogging and anti-adhesive micro-capillary needle with enhanced tip visibility
    7.
    发明授权
    Anti-clogging and anti-adhesive micro-capillary needle with enhanced tip visibility 有权

    公开(公告)号：US11712549B2

    公开(公告)日：2023-08-01

    申请号：US16456695

    申请日：2019-06-28

    Applicant: Kinneret Rand

    Inventor： Kinneret Rand

    IPC: A61M37/00 ,  B33Y80/00

    CPC classification number: A61M37/0015 ,  A61M2037/0053 ,  B33Y80/00 ,  B81B2201/055 ,  B81B2201/057

    Abstract: An object of the present invention is to provide an anti-adhesive/anti-clogging and/or color marked/tinted micro-capillary tube (microtube), microneedle, or micropipette. Typically, the color/tint will be selected such that the tip of the microneedle or micropipette is in contrast (e.g., visually) to the biological material. The tint/color may be selected to contrast the stained biological material. In some aspects, the color mark comprises nanoparticles that are modified by adding a non-adhesive coating/material that minimizes protein adhesion/adsorption. The microtubes and/or micropipettes may be treated with an anti-clogging reagent and an anti-adhesive reagent to prevent or reduce clogging and adhesion of the micropipette or microneedle to biological materials. The microtubes and/or micropipettes may be formed using additive printing processes and additive manufacturing techniques or from micropipette and microneedle pullers.

    Method of manufacturing a probe comprising a cantilever with a conduit
    10.
    发明授权
    Method of manufacturing a probe comprising a cantilever with a conduit 有权
    一种制造探针的方法，其包括具有导管的悬臂

    公开(公告)号：US09086431B2

    公开(公告)日：2015-07-21

    申请号：US13978502

    申请日：2012-01-13

    Applicant: Edin Sarajlic

    Inventor： Edin Sarajlic

    IPC: H01R43/00 ,  G01R3/00 ,  B81C1/00 ,  B01L3/00

    CPC classification number: G01R3/00 ,  B01L3/502707 ,  B81B2201/057 ,  B81B2203/0118 ,  B81B2203/0338 ,  B81C1/00119 ,  B81C2201/0109 ,  Y10T29/49002

    Abstract: The present invention relates to a method of manufacturing a probe comprising a cantilever with a conduit. According to the invention, an etchant window is provided in a layer covering an elongated sacrificial conduit core that is to form the conduit. This allows for an etching process where the elongated sacrificial conduit core is etched away before all material of a substrate is etched away, the remaining material of the substrate material making the probe stronger without being in the way during use of the probe.

    Abstract translation: 本发明涉及一种制造探针的方法，该探针包括具有导管的悬臂。 根据本发明，在覆盖要形成导管的细长牺牲导管芯的层中提供蚀刻剂窗口。 这允许蚀刻工艺，其中在衬底的所有材料被蚀刻掉之前，细长的牺牲导管芯被蚀刻掉，使衬底材料的剩余材料在探针的使用期间不会妨碍探针。

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