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公开(公告)号:US20210299447A1
公开(公告)日:2021-09-30
申请号:US17346971
申请日:2021-06-14
Applicant: MONASH UNIVERSITY
Inventor: Paul B FITZGERALD , Caley M. Sullivan , Richard H. THOMSON
Abstract: Closed-loop transcranial stimulation and monitoring is disclosed that includes generating a stimulation signal having a set of first oscillation parameters; applying the stimulation signal transcranially to a patient; monitoring the stimulation signal as applied to the patient; receiving a brain activity signal from the patient; generating a feedback signal based on the monitored stimulation signal as applied to the patient; and generating a modified activity signal by subtracting the feedback signal from the brain activity signal; determining one or more second oscillation parameters of the modified activity signal; and adjusting the set of first oscillation parameters of the stimulation signal based on the one or more second oscillation parameters of the modified activity signal. Closed-loop transcranial stimulation and monitoring is also disclosed in which the patient is engaged in a cognitive task.
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公开(公告)号:US20210283160A1
公开(公告)日:2021-09-16
申请号:US17201621
申请日:2021-03-15
Applicant: Monash University , Melbourne Health
Inventor: Kylie Michelle WAGSTAFF , Leon CALY , David JANS
IPC: A61K31/7048 , A61K31/365
Abstract: The technology relates to the use of at least one macrocyclic lactone such as ivermectin or moxidectin to inhibit a coronavirus in a subject in order to treat, prevent or reduce the risk of infection by the coronavirus.
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公开(公告)号:US11078488B2
公开(公告)日:2021-08-03
申请号:US16984996
申请日:2020-08-04
Applicant: Monash University
Inventor: Siew Yeen Chai , Robert Widdop , Tracey Gaspari , Huey Wen Lee
IPC: A61K31/395 , A61K31/351 , A61K31/4433 , C12N15/113 , A61K31/4709 , A61K31/55 , A61P1/16 , A61P9/00 , A61P13/12
Abstract: The present invention relates to compositions, methods and kits for the treatment of fibrosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of cardiac fibrosis. The invention provides a method of treating fibrosis in an individual comprising administering an inhibitor of insulin-regulated aminopeptidase (IRAP), thereby treating fibrosis.
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公开(公告)号:US20210078076A1
公开(公告)日:2021-03-18
申请号:US16611897
申请日:2018-05-10
Applicant: Monash University
Inventor: Marten Jurg , Andrey Molotnikov
Abstract: An additive manufacturing system and method is provided for fabricating 3D objects (16) from successive layers (14) of material. The additive manufacturing system (10) has an energy projection assembly (20) for inputting energy (22) into a specified area within the layer (18) to consolidate the material; a plurality of image sensors (30, 32, 34), each of the image sensors having a corresponding field of view (35, 40, 42) covering at least part of the layer (18) of material, such that each of the fields of view at least partially overlap with the field of view of at least one other of the image sensors; and an image processor (56) to capture image data from each of the image sensors (30, 32, 34). The image processor (56) controls exposure times for each of the image sensors (30, 32, 34) and combines the image data from the image sensors to provide a single, spatially resolved image of the energy being input throughout the specified area for each layer (14) of material respectively for comparison against threshold data values to locate potential consolidation defects in the specified area.
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公开(公告)号:US20200291502A1
公开(公告)日:2020-09-17
申请号:US16753480
申请日:2018-10-08
Applicant: MONASH UNIVERSITY
Inventor: Xinhua WU , Xigen ZHOU
Abstract: A “modified” meta-stable # titanium alloy that, apart from carbon content, corresponds to the composition range for standard Beta-C titanium alloy. The modified alloy comprises vanadium, chromium, molybdenum, zirconium, aluminium, with maxima for oxygen, iron, nitrogen, hydrogen, yttrium, and other elements (apart from carbon and titanium), with a balance (apart from carbon) of titanium. The modified alloy has carbon present at a stable total carbon level sufficiently in excess of 0.05 wt. % achieving an improvement in the mechanical properties of UTS, DSS and fatigue strength in threaded regions, relative to standard Beta-C alloy with a specified carbon level below 0.05 wt. %, with a maximum carbon content controlled so as to preclude carbide formation having a detrimental effect on the level of fatigue strength.
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公开(公告)号:US10697955B2
公开(公告)日:2020-06-30
申请号:US16208441
申请日:2018-12-03
Applicant: MONASH UNIVERSITY
Inventor: Bayden R. Wood , Philip Heraud , David Perez-Guaita
IPC: G01J5/00 , G01N33/49 , G01N21/552 , G01N21/3577 , C12Q1/70 , C12Q1/689 , G01N21/35 , G01N33/487
Abstract: The invention principally relates to a method of detecting a disease agent in blood, comprising: (i) creating a sample infra-red spectrum representative of the blood, with one or more spectral components, each having a wavenumber and absorbance value; (ii) providing a reference database of spectral models, each model having one or more database spectral components of a wavenumber and an absorbance value, wherein the database spectral components identify disease agents; (iii) determining whether one or more database spectral components corresponds to one or more sample spectral components, and (iv) compiling a list of corresponding database components identified.
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公开(公告)号:US20190316116A1
公开(公告)日:2019-10-17
申请号:US15535899
申请日:2015-12-15
Applicant: MONASH UNIVERSITY
Inventor: Benjamin POREBSKI , Ashley BUCKLE
Abstract: The invention relates to a highly stable polypeptide scaffold comprising an amino acid sequence based on a fibronectin type III (Fn3) domain and a polypeptide comprising the scaffold with grafted loops. The invention also relates to a nucleic acid molecule encoding the polypeptide scaffold, a method of making the polypeptide scaffold, and a composition comprising the polypeptide scaffold.
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公开(公告)号:US20190307937A1
公开(公告)日:2019-10-10
申请号:US16462910
申请日:2017-11-22
Applicant: Alfred Health , Monash University
Inventor: Mark FITZGERALD , Peter FINNEGAN , Wing CHIU , Nayeem CHOWDHURY , Nabil CHOWDHURY
Abstract: A surgical system for use in establishing and maintaining an opening to an anatomical space of a body, the system comprising an obturator assembly having a cutting portion at a distal end and a cannula, the cannula being detachably coupled to the cutting portion and deployable into the anatomical space of a patient, the cannula comprises a locking portion, and a lengthwise extendable body; a valve assembly comprising a passage for receiving the cannula, a first end for coupling to a fluid extraction device and a second end for placement external and adjacent the anatomical space; a base comprising a plate for placement on a patient external and adjacent the anatomical space, the plate has an aperture configured for receiving the obturator assembly and coupling means located about the aperture for coupling with the valve assembly; and wherein, in use, the locking portion of the cannula is configured to be retained in the valve assembly with the extendable body extended into the anatomical space to facilitate a path for fluid extraction, and wherein the cannula comprises means for retaining the cannula in its extended state.
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公开(公告)号:US20190298743A1
公开(公告)日:2019-10-03
申请号:US16303023
申请日:2017-05-19
Inventor: Nigel Bunnett
Abstract: The present invention relates to compounds and their uses. In particular, to compounds that inhibit endosomal protease-activated receptor-2 (PAR2) signaling and their use in the treatment of pain.
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公开(公告)号:US10426598B2
公开(公告)日:2019-10-01
申请号:US15124402
申请日:2015-03-23
Applicant: Monash University
Inventor: Wai Ho Li
Abstract: A visual image processing method is based on received spatial field information (302) from a spatial field sensor (116). A data store (804) is accessed, which contains a sensor map data structure (206) comprising a set of predefined regions (208) within a spatial field corresponding with the information received via the sensor input. Each predefined region is associated in the data structure with one or more of a set of stimuli (204) applicable to a biological visual system, and each stimulus corresponds with a visual percept (210). The spatial field information associated with each region is processed to generate stimulus control information which is applied to select, from within the sensor map data structure, stimuli from the set of stimuli for application to the biological visual system. Output stimulus signals (310) are generated, which are suitable for application to the biological visual system based upon the selected stimuli. Flexible mappings are thus provided between visual percepts, stimuli which may be applied (e.g. via a prosthetic implant) in order to generate the percepts, and associations between those stimuli and regions of the spatial field corresponding with the visual percepts.
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