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公开(公告)号：KR1020140014031A
公开(公告)日：2014-02-05
申请号：KR1020130144072
申请日：2013-11-25
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
IPC: C12Q1/68 , G01N33/68 , G01N33/563 , C12N15/11
CPC classification number: C12Q1/6883 , C12Q1/6837 , C12Q2525/204 , C12Q2600/136 , C12Q2600/158 , G01N33/54306 , G01N33/6893 , G01N2500/00
Abstract: The present invention relates to a method and a kit for predicting chloasma. More specifically, in order to diagnose possibility of forming the chloasma by checking expression amount of genes which are differently expressed between chloasma tissues and normal skin tissues, a method and a kit for predicting chloasma comprise: one or more polynucleotides or complementary polynucleotides as probes which hybridize with polynucleotides of the sequence of the genes; a pair of polynucleotide primers of the sequence of the genes; or one or more monoclonal antibodies having amino acid sequences coded by the genes as a variable region. According to the present invention, the possibility of forming the chloasma on skin can be sensitively and rapidly diagnosed by using 23 kinds of highly expressed genes and 5 kinds of down regulated genes, which are specific to chloasma lesion area, as chloasma marker genes. [Reference numerals] (AA) Relative mRNA expression amount in melasma regions compare to normal region; (BB) Normal region
Abstract translation: 本发明涉及一种用于预测黄褐斑的方法和试剂盒。 更具体地，为了通过检查在黄褐斑组织和正常皮肤组织之间不同表达的基因的表达量来诊断形成黄褐斑的可能性，用于预测黄褐斑的方法和试剂盒包括：一个或多个多核苷酸或互补多核苷酸作为探针， 与基因序列的多核苷酸杂交; 基因序列的一对多核苷酸引物; 或具有由该基因编码的氨基酸序列作为可变区的一种或多种单克隆抗体。 根据本发明，通过使用23种高度表达的基因和对黄褐斑病变区域特异性的5种下调基因作为黄褐斑标记基因，可以敏感地和快速地诊断形成皮肤上的黄褐斑的可能性。 （AA）与正常区相比，黑斑病区的相对mRNA表达量; （BB）正常区域
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公开(公告)号：KR1020140009660A
公开(公告)日：2014-01-23
申请号：KR1020120075941
申请日：2012-07-12
Applicant: (주)아모레퍼시픽
Abstract: The present invention relates to a composition for skin whitening comprising ARP101. The composition for skin whitening, as one aspect of the present invention, reduces the amount of melanin by reducing the expression of melanogenesis-related proteins, thereby having whitening effects without cytotoxicity.
Abstract translation: 本发明涉及一种包含ARP101的皮肤美白组合物。 作为本发明的一个方面，用于皮肤美白的组合物通过减少黑素生成相关蛋白的表达来减少黑色素的量，从而具有无细胞毒性的美白效果。
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公开(公告)号：KR1020140004607A
公开(公告)日：2014-01-13
申请号：KR1020130144071
申请日：2013-11-25
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
CPC classification number: C12Q1/6883 , C12Q2600/118 , G01N33/53 , G01N33/68
Abstract: The present invention relates to a method for predicting chloasma formation and a diagnostic kit for chloasma formation and, more specifically, to a method for predicting chloasma formation and a diagnostic kit for chloasma formation, capable of diagnosing the possibility of chloasma formation on the skin by confirming the expression levels of genes which are differently expressed between the chloasma tissue and the normal skin tissue, wherein the diagnostic kit comprises: at least one polynucleotide sequence or its complementary polynucleotide as a probe hybridizing with polynucleotide of the gene sequence; a primer pair of the polynucleotide of the gene sequence; or at least one monoclonal antibody having, as a variable region, an amino acid sequence coded by the gene. According to the present invention, 23 high-expression genes and five low-expression genes, which are specific to a chloasma lesion, are used as a chloasma marker gene, thereby precisely and promptly diagnosing the possibility of chloasma formation on the skin. [Reference numerals] (AA) Relative mRNA expression level of a chloasma region as compared with a normal region; (BBC) Normal region
Abstract translation: 本发明涉及一种用于预测黄褐斑形成的方法和用于黄褐斑形成的诊断试剂盒，更具体地，涉及用于预测黄褐斑形成的方法和用于形成黄褐斑的诊断试剂盒，其能够诊断皮肤上形成黄褐斑的可能性 确认在黄褐斑组织和正常皮肤组织之间不同表达的基因的表达水平，其中所述诊断试剂盒包含：至少一种多核苷酸序列或其互补多核苷酸作为与所述基因序列的多核苷酸杂交的探针; 基因序列的多核苷酸的引物对; 或至少一种具有由该基因编码的氨基酸序列作为可变区的单克隆抗体。 根据本发明，将23个高表达基因和5个低度表达基因（其特异性为黄褐斑病变）用作黄褐斑标记基因，从而准确且及时地诊断皮肤上形成黄褐斑的可能性。 （附图标记）（AA）与正常区域相比，黄褐斑区域的相对mRNA表达水平; （BBC）正常区域
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公开(公告)号：KR1020130115482A
公开(公告)日：2013-10-22
申请号：KR1020120037794
申请日：2012-04-12
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: An external use skin composition containing a germinated green tea seed extract is provided to prevent and treat skin dryness, to improve skin tone, to remove skin dead cells, and to show anti-dandruff effect. CONSTITUTION: An external use skin composition contains 0.001-50 wt% of a germinated green tea seed extract as an active ingredient. The green tea extract is prepared by subcritical extraction. The composition is used for protecting skin or dandruff. The composition is used for preventing or treating skin aging and wrinkles.
Abstract translation: 目的：提供含有发芽绿茶种子提取物的外用皮肤组合物，以预防和治疗皮肤干燥，改善肤色，去除皮肤死细胞，并显示出抗头皮屑效果。 构成：外用皮肤组合物含有0.001-50重量％的发芽绿茶种子提取物作为活性成分。 绿茶提取物通过亚临界萃取法制备。 该组合物用于保护皮肤和头皮屑。 该组合物用于预防或治疗皮肤老化和皱纹。
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公开(公告)号：KR1020130068319A
公开(公告)日：2013-06-26
申请号：KR1020110135359
申请日：2011-12-15
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A composition containing a Kalopanax pictus (Thunb.) Nakai extract is provided to improve anti-aging, anti-wrinkling, and moisturizing effects. CONSTITUTION: An external use skin composition contains 0.001-50wt% of a Kalopanax pictus (Thunb.) Nakai extract as an active ingredient. The composition is used for improving anti-aging, skin elasticity, and anti-wrinkling, and strengthening skin barrier function.
Abstract translation: 目的：提供含有Kalopanax pictus（Thunb。）Nakai提取物的组合物，以改善抗衰老，抗皱和保湿作用。 构成：外用皮肤组合物含有0.001-50wt％的Kalopanax pictus（Thunb。）Nakai提取物作为活性成分。 该组合物用于改善抗衰老，皮肤弹性和抗皱纹，并增强皮肤屏障功能。
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Patent Agency Ranking
公开(公告)号：KR1020130062484A
公开(公告)日：2013-06-13
申请号：KR1020110128727
申请日：2011-12-05
Applicant: (주)아모레퍼시픽
IPC: A61K36/185 , A61K8/97 , A61P17/00 , A61Q19/00
Abstract: PURPOSE: A composition containing a Humulus japonicas Sieboid & Zucc. extract is provided to ensure a skin whitening effect and to be used for a cosmetic product or in a pharmaceutical field. CONSTITUTION: An external use skin composition contains 0.001-50 wt% of a Humulus japonicas Sieboid & Zucc. extract as an active ingredient. The composition is used for skin whitening. A cosmetic composition contains the extract as an active ingredient.
Abstract translation: 目的：一种含有葎草japonicas Sieboid＆Zucc的组合物。 提供提供物以确保皮肤美白效果并用于化妆品或制药领域。 构成：外用皮肤组合物含有0.001-50重量％的葎草japonicas Sieboid＆Zucc。 提取物作为活性成分。 该组合物用于皮肤美白。 化妆品组合物含有提取物作为活性成分。
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97.发明公开한라송이풀 추출물을 함유하는 피부 외용제 조성물 审中-实审含有PERICULARIS VERTICILLATA LINNE VAR.HALLAISANENSIS EXTRACT的皮肤外用组合物
公开(公告)号：KR1020130062046A
公开(公告)日：2013-06-12
申请号：KR1020110128448
申请日：2011-12-02
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: An external use skin composition containing a Pedicularis verticillata Linne var.hallaisanensis extract is provided to improve whitening, antiaging, and moisturizing effects. CONSTITUTION: An external use skin composition contains 0.001-50 wt% of a Pedicularis verticillata Linne var.hallaisanensis extract as an active ingredient. The composition is used for whitening, antiaging, elasticity improvement, anti-wrinkling, and moisturization effects.
Abstract translation: 目的：提供含有Pedicularis verticillata Linne var.hallaisanensis提取物的外用皮肤组合物，以改善美白，抗衰老和保湿效果。 构成：外用皮肤组合物含有0.001-50重量％的Pedicularis verticillata Linne var.hallaisanensis提取物作为活性成分。 该组合物用于美白，抗衰老，弹性改善，抗皱和保湿效果。
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公开(公告)号：KR1020130062043A
公开(公告)日：2013-06-12
申请号：KR1020110128443
申请日：2011-12-02
Applicant: (주)아모레퍼시픽
IPC: A61K36/898 , A61P17/00 , A61K8/97 , A61Q19/00
Abstract: PURPOSE: An external use skin composition containing a Calanthe discolor Lindl. extract is provided to enhance an antioxidation effect. CONSTITUTION: An external use skin composition contains 0.001-50 wt% of a Calanthe discolor Lindl. extract as an active ingredient. The composition is used for antioxidation, skin elasticity improvement, and anti-wrinkling.
Abstract translation: 目的：外用皮肤组合物，含有Calanthe褪色Lindl。 提取物提供抗氧化作用。 构成：外用皮肤组合物含有0.001-50重量％的Calanthe褪色Lindl。 提取物作为活性成分。 该组合物用于抗氧化，皮肤弹性改善和抗起皱。
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公开(公告)号：KR101155180B1
公开(公告)日：2012-06-13
申请号：KR1020090016712
申请日：2009-02-27
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 피부에 유해한 자외선을 차단함과 동시에 자외선으로 인한 피부속 노화까지 차단하는 항노화용 자외선 차단 화장료 조성물에 관한 것으로, 보다 상세하게는 자외선 차단 성분에 파피아 글로메라타 뿌리즙(pfaffia glomerata rhizome extract) 및 아르기닌 PCA(arginine PCA)를 함유함으로써 자외선으로 인한 피부속 신경세포의 손상과 그로 인한 각질형성세포 및 섬유아세포의 손상까지 억제하는 항노화용 자외선 차단 화장료 조성물에 관한 것이다.
파피아 글로메라타 뿌리즙, 아르기닌 PCA, 주름개선, 자외선 차단, 신경세포 손상, 화장료 조성물-
公开(公告)号：KR101141907B1
公开(公告)日：2012-05-03
申请号：KR1020050069505
申请日：2005-07-29
Applicant: (주)아모레퍼시픽
Abstract: A method for inhibiting melanosome migration by using prohibitin siRNA(small interference RNA) is provided to inhibit expression of prohibitin in a melanin synthesis cell and uniformed distribution of melanosome in the melanin synthesis cell, so that the skin is whitened. The melanosome migration to the end of melanin synthesis cell is inhibited by administering prohibitin siRNA into the melanin synthesis cell, melan-a, thereby inhibiting binding of prohibitin to melanophilin as a melanosome vehicle and uniformed distribution of melanosome in the melanin synthesis cell.
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