公开(公告)号：KR101144563B1

公开(公告)日：2012-05-11

申请号：KR1020100040518

申请日：2010-04-30

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  전주연 ,  오혜좌

IPC: A01K67/027

Abstract: PURPOSE: An arthritis mouse animal model and a manufacturing method thereof are provided to more seriously a symptom of arthritis. CONSTITUTION: A manufacturing method of an arthritis mouse animal model comprises: a step of inducing obesity by feeding high caloric fodder to mouse; and a step of causing arthritis by ministering collagen in the mouse. In the collagen ministering step, collagen is inoculated firstly, a mouse is bred for a specified period, and collagen is inoculated secondly. In the first inoculation, mixture solution of collagen and complete freud's adjuvant is administered. In the second inoculation, mixture solution of collagen and incomplete freud's adjuvant is administered.

公开(公告)号：KR1020120032649A

公开(公告)日：2012-04-06

申请号：KR1020100094091

申请日：2010-09-29

Applicant: 한림제약(주) ,  가톨릭대학교 산학협력단

Inventor： 조미라 ,  우윤주 ,  박미경 ,  민준기 ,  오혜좌 ,  류종현 ,  이근혁 ,  최병선 ,  조경주 ,  박진하 ,  곽은영

IPC: A61K36/87 ,  A61K9/20 ,  A61P19/02

Abstract: PURPOSE: A pharmaceutical composition containing rebamipide and Vitis vinifera seed extract is provided to prevent or treat rheumatoid arthritis. CONSTITUTION: A pharmaceutical composition for preventing or treating rheumatoid arthritis contains rebamipide and Vitis vinifera seed extract. The pharmaceutical composition is orally administered in the form of a tablet or capsule. The dosage of rebamipide is 0.3 mg/kg a day.

Abstract translation: 目的：提供含有瑞巴派特和葡萄种子提取物的药物组合物，以预防或治疗类风湿性关节炎。 构成：用于预防或治疗类风湿性关节炎的药物组合物含有瑞巴派特和葡萄籽种子提取物。 药物组合物以片剂或胶囊的形式口服给药。 瑞巴派特的剂量为每天0.3mg / kg。

公开(公告)号：KR1020120021239A

公开(公告)日：2012-03-08

申请号：KR1020110086459

申请日：2011-08-29

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  우윤주 ,  박미경 ,  민준기

IPC: A61K31/4704 ,  A61P35/00

CPC classification number: A61K31/4704

Abstract: PURPOSE: A composition containing rebamipide for preventing or treating cancer or immune diseases is provided to suppress Th17 cell differentiation and to enhance immune regulatory T cell activity. CONSTITUTION: A composition for preventing or treating cancer or immune diseases contains rebamipid compounds or pharmaceutically acceptable salt thereof as an active ingredient. The immune diseases include autoimmune disease, inflammatory disease, and transplantation rejection. A method for reducing or suppressing differentiation of immature T cells into Th17 cell in vitro comprises a step of treating rebamipid compounds or pharmaceutically acceptable salt thereof.

Abstract translation: 目的：提供含有用于预防或治疗癌症或免疫疾病的瑞巴派特的组合物以抑制Th17细胞分化并增强免疫调节性T细胞活性。 构成：用于预防或治疗癌症或免疫疾病的组合物含有雷米帕派化合物或其药学上可接受的盐作为活性成分。 免疫疾病包括自身免疫性疾病，炎性疾病和移植排斥反应。 用于在体外降低或抑制未成熟T细胞分化成Th17细胞的方法包括处理rebamipid化合物或其药学上可接受的盐的步骤。

公开(公告)号：KR1020110137588A

公开(公告)日：2011-12-23

申请号：KR1020100057601

申请日：2010-06-17

Applicant: 에이치 엘 지노믹스(주) ,  가톨릭대학교 산학협력단

Inventor： 조미라 ,  민준기 ,  전주연 ,  오혜좌 ,  류종현 ,  이근혁 ,  최병선 ,  조경주 ,  박진하 ,  곽은영

IPC: A61K36/87 ,  A61P3/04 ,  A61P3/00

Abstract: PURPOSE: A pharmaceutical composition containing Vitis vinifera seed extract and pharmaceutically acceptable carrier is provided to prevent and treat obesity. CONSTITUTION: A pharmaceutical composition for preventing or treating obesity contains Vitis vinifera seed extract and pharmaceutically acceptable carrier. The extract has 80-130 of procyanidolic value(PCV) and contains less than 30% of (+)catechin and (-) epicatechin and 95-105% of proanthocyanidin content. A method for preparing the extract comprises: a step of mixing pulverized Vitis vinifera seed and a mixture solvent of acetone and water and isolating at room temperature; a step of filtering the extract and distilling the filtered liquid to remove acetone; a step of saturating sodium chloride and filtering; a step of extracting the liquid with ethyl acetate and concentrating; and a step of adding chloroform and filtering.

Abstract translation: 目的：提供含有葡萄籽提取物和药学上可接受的载体的药物组合物以预防和治疗肥胖症。 构成：用于预防或治疗肥胖症的药物组合物含有葡萄种子提取物和药学上可接受的载体。 提取物具有80-130原花青素值（PCV），并且含有少于30％的（+）儿茶素和（ - ）表儿茶素和95-105％的原花色素含量。 一种制备提取物的方法包括：将经粉碎的葡萄种子和丙酮和水的混合溶剂混合并在室温下分离的步骤; 过滤提取物并蒸馏过滤的液体以除去丙酮的步骤; 使氯化钠饱和并过滤的步骤; 用乙酸乙酯萃取液体并浓缩的步骤; 并加入氯仿和过滤步骤。

公开(公告)号：KR1020110125495A

公开(公告)日：2011-11-21

申请号：KR1020100045058

申请日：2010-05-13

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  문영미 ,  이선영

IPC: A61K48/00 ,  A61K31/7105 ,  C07K14/47

CPC classification number: A61K31/7105 ,  A61K48/005 ,  C07K14/4703 ,  A61K2121/00

Abstract: PURPOSE: A composition containing PIAS3 for preventing or treating cancer or immune diseases is provided to suppress the differentiation of cytotoxic Th17 cell. CONSTITUTION: A composition for preventing or treating cancer or immune diseases contains PIAS3 gene or protein of the gene as an active ingredient. PIAS3 reduces or suppresses the differentiation of undifferentiated T cells into Th17 cells. The immune diseases are autoimmune disease, inflammatory disease, or transplantation rejection. A composition for suppressing immunity contains the PIAS3 gene or protein thereof as an active ingredient.

Abstract translation: 目的：提供含有预防或治疗癌症或免疫疾病的PIAS3的组合物，以抑制细胞毒Th17细胞的分化。 构成：用于预防或治疗癌症或免疫疾病的组合物含有该基因的PIAS3基因或蛋白质作为活性成分。 PIAS3可降低或抑制未分化T细胞分化为Th17细胞。 免疫疾病是自身免疫性疾病，炎性疾病或移植排斥反应。 用于抑制免疫的组合物含有PIAS3基因或其蛋白质作为活性成分。

公开(公告)号：KR1020110121086A

公开(公告)日：2011-11-07

申请号：KR1020100040518

申请日：2010-04-30

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  전주연 ,  오혜좌

IPC: A01K67/027

CPC classification number: A01K67/027 ,  A01K2207/25 ,  A01K2227/105 ,  A01K2267/03

Abstract: PURPOSE: An arthritis mouse animal model and a manufacturing method thereof are provided to more seriously a symptom of arthritis. CONSTITUTION: A manufacturing method of an arthritis mouse animal model comprises: a step of inducing obesity by feeding high caloric fodder to mouse; and a step of causing arthritis by ministering collagen in the mouse. In the collagen ministering step, collagen is inoculated firstly, a mouse is bred for a specified period, and collagen is inoculated secondly. In the first inoculation, mixture solution of collagen and complete freud's adjuvant is administered. In the second inoculation, mixture solution of collagen and incomplete freud's adjuvant is administered.

Abstract translation: 目的：提供关节炎小鼠动物模型及其制造方法，以更严重地关注关节炎的症状。 构成：关节炎小鼠动物模型的制造方法包括：通过向小鼠喂食高热量饲料来诱导肥胖的步骤; 以及通过在小鼠中服用胶原来引起关节炎的步骤。 在胶原蛋白传代步骤中，首先接种胶原，将小鼠育种一段指定的时间，然后接种胶原蛋白。 在第一次接种中，施用胶原蛋白和完全弗氏佐剂的混合溶液。 在第二次接种中，施用胶原蛋白和不完全弗氏佐剂的混合溶液。

公开(公告)号：KR101044433B1

公开(公告)日：2011-06-27

申请号：KR1020080087109

申请日：2008-09-04

Applicant: 가톨릭대학교 산학협력단 ,  에이치 엘 지노믹스(주)

Inventor： 민준기 ,  조미라 ,  박미경 ,  허유정 ,  박진실 ,  김호연 ,  류종현 ,  김현규 ,  이근혁

IPC: A61K36/87 ,  A61P19/02

CPC classification number: A61K36/87

Abstract: 본 발명은 유럽종 포도(
Vitis

vinifera )의 씨 추출물의 개선된 제조방법을 제공한다. 또한, 본 발명은 유럽종 포도(
Vitis

vinifera )의 씨 추출물 및 약제학적으로 허용가능한 담체를 포함하는 류마티스 관절염의 예방 또는 치료용 약학 조성물을 제공한다.
유럽종 포도, 류마티스 관절염

公开(公告)号：KR1020110021016A

公开(公告)日：2011-03-04

申请号：KR1020090078547

申请日：2009-08-25

Applicant: 가톨릭대학교 산학협력단 ,  한림제약(주)

Inventor： 민준기 ,  조미라 ,  우윤주 ,  오혜좌 ,  전주연 ,  이근혁 ,  박세완 ,  박진하 ,  곽은영

IPC: A61K31/4704 ,  A61P19/02 ,  A61K9/20 ,  A61K9/48

CPC classification number: A61K31/4704

Abstract: PURPOSE: A pharmaceutical composition containing rabamipide and pharmaceutically acceptable carrier is provided to prevent or treat rheumatoid arthritis. CONSTITUTION: A pharmaceutical composition for preventing or treating rheumatoid arthritis contains rabamipid and pharmaceutically acceptable carrier. The pharmaceutical composition is used for oral administration. The pharmaceutical composition is formed in oral solid dosage. The pharmaceutical composition has rabamipid formulated in 0.5-50 mg/kg of unit dosage form.

Abstract translation: 目的：提供含有拉巴米特和药学上可接受的载体的药物组合物，以预防或治疗类风湿性关节炎。 构成：用于预防或治疗类风湿性关节炎的药物组合物含有拉帕米特和药学上可接受的载体。 药物组合物用于口服给药。 药物组合物以口服固体剂量形成。 药物组合物具有配制在0.5-50mg / kg单位剂型中的拉巴米特。

公开(公告)号：KR102256159B1

公开(公告)日：2021-05-26

申请号：KR1020140153669

申请日：2014-11-06

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  박성환 ,  박원상 ,  송교영 ,  문영미 ,  서현범 ,  이선영 ,  이승훈 ,  김은경 ,  김재경

IPC: A61K38/16 ,  A61K48/00 ,  A61P19/02 ,  A61P19/00

Abstract: 본발명은 GKN 1을유효성분으로함유하는자가면역질환의예방또는치료용조성물에관한것으로, 보다구체적으로는 GKN 1 유전자를포함하는발현벡터또는 GKN 1 단백질을유효성분으로함유하는자가면역질환의예방또는치료용조성물에관한것이다. 본발명에따른 GKN 1은자가면역질환이발병한동물모델을대상으로상기단백질을과발현시킨경우자가면역질환의증상이개선되는것으로나타났고, 특히파골세포분화를효과적으로억제할수 있어골 관절염및 류마티스관절염을포함하는자가면역질환의치료제개발에유용하게사용할수 있는효과가있다.

公开(公告)号：KR102211959B1

公开(公告)日：2021-02-05

申请号：KR1020140107569

申请日：2014-08-19

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  문수진 ,  박진실 ,  문영미 ,  임미애 ,  김은경 ,  변재경 ,  김성민 ,  서현범

IPC: A61K38/16 ,  A61P19/10 ,  A61P19/00

Abstract: 본발명은 DUSP5를유효성분으로모두포함하는골대사성질환의예방또는치료용약학적조성물, STAT3 매개질환의예방또는치료용약학적조성물및 DUSP5을이용한 STAT3의활성억제방법에관한것으로, 본발명은 DUSP5는파골세포분화와관련된 RANKL, RANK, NFATc1 및 TRAP의발현또는활성을효과적으로억제할수 있고, Th17의활성을억제또는감소시키고조절 T 세포(Regulatory T cell: Treg)의활성을촉진또는증가시키는작용이동시에가능하며, STAT3의인산화억제를통해 STAT3의활성을억제할수 있어, 골대사성질환및 STAT3 매개로인한질환을치료할수 있는새로운치료제로서유용하게활용가능할것이다.