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    SYNTHESIS OF OPTICALLY ACTIVE AMINOINDANOL
    91.
    发明专利
    SYNTHESIS OF OPTICALLY ACTIVE AMINOINDANOL 未知

    公开(公告)号：CA2217880C

    公开(公告)日：2004-02-24

    申请号：CA2217880

    申请日：1996-05-07

    Applicant: BASF AG

    Inventor： NUBLING CHRISTOPH ,  LADNER WOLFGANG

    IPC: C07C213/02 ,  C07C213/08 ,  C07C213/10 ,  C07C217/52 ,  C07C233/23 ,  C07C271/24 ,  C07C271/56 ,  C07C215/44

    Abstract: A process for preparing enantiomerically pure cis-1-amino- 2-hydroxyindan, which comprises a) converting racemic trans-1-aminoindan-2-ol with acids or acid derivatives of the general formula RCOX by conventional methods into amides of type A where the substituents have the following meanings: R is hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl and phenyl, it being possible for these groups to carry one to three halogen atoms and/or one to three of the following radicals: cyano, C1-C6-alkoxy, C1-C6-alkylthio, phenyl, phenylthio and phenoxy, it being possible for the phenyl radicals in turn to carry one to three of the following groups: C1-C4-alkyl, C1-C4-alkoxy, halogen, cyano and nitro, X is OH, halogen, OR1 and SR1, where R1 is C1-C6-alkyl, phenyl and COR, b) adding seed crystals of one enantiomer to a supersaturated solution or melt of the racemic amide A, c) isolating the crystals which have separated out, and again supersaturating the remaining mother liquor or melt after dissolving racemic amide A, and adding seed crystals of the other enantiomer, leading to selective crystallization of the latter, d) converting the resulting enantiomerically pure traps amide by conventional methods into the enantiomerically pure cis-1-amino-2-hydroxyindan.

    92.
    发明专利
    未知

    公开(公告)号：PT824512E

    公开(公告)日：2001-04-30

    申请号：PT96915021

    申请日：1996-05-07

    Applicant: BASF AG

    Inventor： LADNER WOLFGANG ,  NUBLING CHRISTOPH

    IPC: C07C213/02 ,  C07C213/08 ,  C07C213/10 ,  C07C217/52 ,  C07C233/23 ,  C07C271/24 ,  C07C271/56

    Abstract: PCT No. PCT/EP96/01884 Sec. 371 Date Oct. 28, 1997 Sec. 102(e) Date Oct. 28, 1997 PCT Filed May 7, 1996 PCT Pub. No. WO96/35660 PCT Pub. Date Nov. 14, 1996A process for preparing enantiomerically pure cis-1-amino-2-hydroxyindane, which comprises a) converting racemic trans-1-aminoindan-2-ol with acids or acid derivatives of the general formula RCOX by conventional methods into amides of type A A b) adding seed crystals of one enantiomer to a super-saturated solution or melt of the racemic amide A, c) isolating the crystals which have separated out, and again supersaturating the remaining mother liquor or melt after dissolving racemic amide A, and adding seed crystals of the other enantiomer, leading to selective crystallization of the latter, d) converting the resulting enantiomerically pure trans amide by conventional methods into the enantiomerically pure cis-1-amino-2-hydroxyindane.

    93.
    发明专利
    未知

    公开(公告)号：PT720655E

    公开(公告)日：2000-04-28

    申请号：PT94928365

    申请日：1994-09-16

    Applicant: BASF AG

    Inventor： HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  BALKENHOHL FRIEDHELM ,  NUBLING CHRISTOPH

    IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

    Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

    94.
    发明专利
    未知

    公开(公告)号：AT191451T

    公开(公告)日：2000-04-15

    申请号：AT96931783

    申请日：1996-09-09

    Applicant: BASF AG

    Inventor： DITRICH KLAUS ,  BALKENHOHL FRIEDHELM ,  LADNER WOLFGANG

    IPC: C12M1/40 ,  B01J23/04 ,  C07B53/00 ,  C07B61/00 ,  C07C69/708 ,  C07C209/62 ,  C07C211/27

    Abstract: PCT No. PCT/EP96/03948 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Sep. 9, 1996 PCT Pub. No. WO97/10201 PCT Pub. Date Mar. 20, 1997The present invention relates to a process for cleaving optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, wherein the amides are hydrolyzed in the presence of a polyol or of an amino alcohol and of an alkali metal or alkaline earth metal hydroxide.

    96.
    发明专利
    未知

    公开(公告)号：DK0714447T3

    公开(公告)日：1998-10-07

    申请号：DK94925459

    申请日：1994-08-17

    Applicant: BASF AG

    Inventor： LADNER WOLFGANG ,  RETTENMAIER HANSJOERG ,  ZIPPERER BERNHARD ,  HANSEN HANSPETER

    IPC: C12P7/52 ,  C07C51/09 ,  C07C53/19 ,  C12P7/40 ,  C12P41/00

    Abstract: PCT No. PCT/EP94/02738 Sec. 371 Date Feb. 15, 1996 Sec. 102(e) Date Feb. 15, 1996 PCT Filed Aug. 17, 1994 PCT Pub. No. WO95/06130 PCT Pub. Date Mar. 2, 1995A process for the preparation of (L)-2-chloropropionic acid and its alkali metal, alkaline earth metal or ammonium salts which comprises hydrolyzing isobutyl L-chloropropionate at a pH of from 4 to 8 in the presence of a lipase from Pseudomonas spec. DSM 8246 and isolating the optically active reaction product from the reaction mixture either directly or after conversion of the salt into the acid in a conventional way, or further reacting it in situ. The optically active products are important intermediates for preparing crop protection agents.\!

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